ChemDiv in Publications and Patents
Anti-oral Squamous Cell Carcinoma Effects of a Potent TAZ Inhibitor AR-42
Lingyu Su; Si Wang; Ting Yuan; Xudong Xie; Xiaoming Fu; Ping Ji; Lei Zhong; Wenzhao Liu
PMC ID: PMC6930442 | DOI: 10.7150/jca.32436 |Journal: Journal of Cancer, 11(1) pp. 364-373 | Publisher: IvyspringInternational Publisher |Publication date: 2020-01-01
Originaldocument: PMC | Score: 16.650314 | Text size: 33910 | Find: similardocuments
In brief,HEK293-TAZ cells were seeded in 96-well plates, and treated with smallmolecules from ChemDivcompound library and an in-house focused libraryfor 24 h at 37 °C. ... reporter assay on HEK293-TAZ cells to screen TAZinhibitor in an in-house focused library and ChemDiv compoundlibrary, and found that the HDAC inhibitor AR-42 (Fig.
Mateo I. Sanchez; Laura E. deVries;ChristineLehmann;Jeong T. Lee; Kenny K. Ang; ChristopherWilson;Steven Chen; Michelle R.Arkin;Matthew Bogyo; Edgar Deu; Luzia HelenaCarvalho
PMC ID: PMC6919601 | DOI: 10.1371/journal.pone.0226270 |Journal: PLoS ONE, 14(1) | Publisher: PublicLibrary of Science | Publicationdate: 2019-12-18
Original document: PMC | Score: 13.996932 | Text size: 57294 | Find: similardocuments
is composedof 104,121 compounds and was assembled from numerous commercial vendors(ChemBridge,ChemDiv and SPECS), and the Celera Protease InhibitorCollection of 1,817 compounds, which is unique and
Discovery of Non-peptide Small Molecule Allosteric Modulators of theSrc-family Kinase, Hck
Heather R.Dorman;David Close; Bentley M.Wingert;Carlos J.Camacho;Paul A. Johnston; Thomas E.Smithgall
PMC ID: PMC6893557 | DOI: 10.3389/fchem.2019.00822 |Journal: Frontiers in Chemistry, 7(1) | Publisher: Frontiers Media S.A. |Publication date: 2019-11-28
Originaldocument: PMC | Score: 13.996932 | Text size: 48193 | Find: similardocuments
Screeninglibraries were purchased from ChemDiv (10,000 non-peptidepeptidomimetic library) and ChemBridge (50,000 compound diversity library).
Puay-Wah Phuan; Joseph-AnthonyTan;Amber A. Rivera; Lorna Zlock; Dennis W.Nielson;Walter E.Finkbeiner;Peter M. Haggie; Alan S. Verkman
PMC ID: PMC6881293 | DOI: 10.1038/s41598-019-54158-2 |Journal: Scientific Reports, 9(1) | Publisher: NaturePublishing Group UK |Publication date: 2019-11-27
Originaldocument: PMC | Score: 14.2392435 | Text size: 45168 | Find: similar documents
Forscreening, 120,000 diverse drug-like synthetic compounds (ChemDiv Inc.,San Diego, CA) were tested. Other chemicals were purchased from Sigma unlessotherwise stated.
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2inhibitors
Irina Kufareva; Benoit Bestgen; Paul Brear; Renaud Prudent; BéatriceLaudet;VirginieMoucadel;MohamedEttaoussi;Celine F. Sautel; Isabelle Krimm; Matthias Engel; Odile Filhol; Marc Le Borgne; ThierryLomberget;Claude Cochet; Ruben Abagyan
PMC ID: PMC6828666 | DOI: 10.1038/s41598-019-52141-5 |Journal: Scientific Reports, 9(1) | Publisher: NaturePublishing Group UK |Publication date: 2019-11-04
Originaldocument: PMC | Score: 13.536236 | Text size: 82786 | Find: similardocuments
reagent gradeor better and were supplied by the following companies: Chembridge (San Diego,CA), ChemDiv(San Diego, CA), Enamine (Kiev, Ukraine),InterBioScreen (Moscow, Russia), LifeChemicals (Kiev,
Novel Hit Compounds as Putative Antifungals: The Case of Aspergillusfumigatus
Eftichia Kritsi; Minos-TimotheosMatsoukas;ConstantinosPotamitis;Anastasia Detsi; Marija Ivanov; Marina Sokovic; Panagiotis Zoumpoulakis;AthinaGeronikaki;Rino Ragno
PMC ID: PMC6864791 | DOI: 10.3390/molecules24213853 |Journal: Molecules, 24(1) | Publisher: MDPI | Publication date: 2019-10-25
Original document: PMC | Score: 14.363574 | Text size: 49217 | Find: similardocuments
Sample Availability:Samples of the compounds 1–2, 3–5 and 6–8 were purchased from ChemDiv,Mcule and eMolecules, respectively. Supplementary Materials The following areavailable online.
Emmanuel Bresso; Diana Fernandez; Deisy X. Amora; Philippe Noel; Anne-SophiePetitot;Maria-EugêniaLisei de Sa;Erika V. S.Albuquerque;Etienne G. J.Danchin;Bernard Maigret; NatáliaF. Martins
PMC ID: PMC6832152 | DOI: 10.3390/molecules24203798 |Journal: Molecules, 24(1) | Publisher: MDPI | Publication date: 2019-10-22
Originaldocument: PMC | Score: 17.646307 | Text size: 62242 | Find: similardocuments
selectedmolecules allowed the identification of an active compound, namely C260-2124,from the ChemDivprovider, which can serve as a starting point forfurther investigations. ... From this list, it appeared that 85 compounds camefrom the ChemDiv provider’s library. ... the GPCR-centredlibraries encompassing six compounds providers: Asinex [73], Chembridge[74], ChemDiv [75], LifeChemicals [76], Otava [77] andSelleckchem [78], representing 112,951 molecules.
Design and Selection of Novel C1s Inhibitors by In Silico and In VitroApproaches
KatalinSzilágyi; IstvánHajdú; BeátaFlachner;ZsoltLőrincz; JúliaBalczer;PéterGál;PéterZávodszky; Chiara Pirli; BalázsBalogh;István M.Mándity;SándorCseh;GyörgyDormán
PMC ID: PMC6832932 | DOI: 10.3390/molecules24203641 |Journal: Molecules, 24(1) | Publisher: MDPI | Publication date: 2019-10-09
Originaldocument: PMC | Score: 16.44229 | Text size: 76556 | Find: similardocuments
removal ofthe duplicated structures resulted in 445,457 compounds (Enamine (71,311compounds), ChemDiv(258,797 compounds), Chembridge (60,052 compounds),Interbioscreen (31,255 compounds) and Life ... from the actual edition of thetop vendor databases (~5 million compounds): Asinex, ChemBridge, ChemDiv,Enamine, Interbioscreen, Life Chemicals, Specs, UkrOrg, etc.[21,22,23,24,25,26,27,28].
A Small-Molecule Pan-Id Antagonist Inhibits Pathologic OcularNeovascularization
Paulina M.Wojnarowicz;Raquel Lima eSilva;Masayuki Ohnaka; Sang Bae Lee; Yvette Chin; Anita Kulukian; Sung-Hee Chang; Bina Desai; Marta GarciaEscolano;Riddhi Shah; Marta Garcia-Cao; Sijia Xu; Rashmi Kadam; Yehuda Goldgur; Meredith A.Miller;OuathekOuerfelli;Guangli Yang;Tsutomu Arakawa; Steven K.Albanese;William A.Garland;Glenn Stoller; JaideepChaudhary;Larry Norton; Rajesh KumarSoni;John Philip; Ronald C.Hendrickson;Antonio Iavarone; Andrew J.Dannenberg;John D. Chodera; Nikola Pavletich; Anna Lasorella; Peter A.Campochiaro;Robert Benezra
PMC ID: PMC6896334 | DOI: 10.1016/j.celrep.2019.08.073 |Journal: Cell reports, 29(1) pp. 62-75.e7 |Publicationdate: 2019-10-01 | Print publication date: 2019-10-01
Originaldocument: PMC | Score: 13.104898 | Text size: 96574 | Find: similardocuments
Compiledlists of commercially available compounds (libraries available fromChemBridge, ChemDiv, Maybridge, and Salor) were screened using abeta release of Autodock 4.0 (The Scripps Research
Identification of Fatty Acid Binding Protein 5 Inhibitors Through Similarity-BasedScreening
Yuchen Zhou; Matthew W. Elmes; Joseph M.Sweeney;Olivia M. Joseph; Joyce Che; Hao-Chi Hsu; Huilin Li; Dale G. Deutsch; Iwao Ojima; Martin Kaczocha; Robert C. Rizzo
PMC ID: PMC6812325 | DOI: 10.1021/acs.biochem.9b00625 |ISSN: 0006-2960 | Journal: Biochemistry, 58(1) pp. 4304-4316 |Publisher:AmericanChemical Society | Publicationdate: 2019-09-20 | Print publication date: 2019-10-22
Originaldocument: PMC | Score: 14.2392435 | Text size: 67063 | Find: similardocuments
in thebinding site from different rank-ordered lists, 78 compounds were ultimatelypurchased (ChemDivvendor) for experimental testing.
Giulia OliveiraTimo;Rodrigo SouzaSilva Valle dos Reis; AdrianaFrançozo de Melo; Thales VianaLabourdette Costa; Pérola deOliveira Magalhães;MauricioHomem-de-Mello
PMC ID: PMC6789803 | DOI: 10.3390/ph12030135 |Journal: Pharmaceuticals, 12(1) | Publisher: MDPI | Publication date: 2019-09-16
Original document: PMC | Score: 14.490094 | Text size: 58450 | Find: similardocuments
CollaborativeDrug Discovery Database [49,50]; Other (CDRI [60], FDA approved drugs[67], ChemDiv [6], ChemSpider [59], TAACF [16], GSK [16],Enamine REAL [61], NCI [21] and Specs [70]).
Leishmania mexicana Trypanothione Reductase Inhibitors: Computational andBiological Studies
Félix Matadamas-Martínez; AliciaHernández-Campos; AlfredoTéllez-Valencia; AlejandraVázquez-Raygoza; SandraComparán-Alarcón; LiliánYépez-Mulia; Rafael Castillo
PMC ID: PMC6767256 | DOI: 10.3390/molecules24183216 |Journal: Molecules, 24(1) | Publisher: MDPI | Publication date: 2019-09-04
Originaldocument: PMC | Score: 14.301138 | Text size: 52177 | Find: similardocuments
GeneralInformation Compounds ZINC04684558 and ZINC09642432 were purchased from ChemDiv (SanDiego, CA, USA), and compounds ZINC12151998, ZINC14970552, and ZINC11841871were purchased
Identification of Novel Antibacterials Using Machine Learning Techniques
Yan A. Ivanenkov; Alex Zhavoronkov; Renat S.Yamidanov;Ilya A. Osterman; Petr V. Sergiev; Vladimir A.Aladinskiy;Anastasia V.Aladinskaya;Victor A.Terentiev;Mark S. Veselov; Andrey A.Ayginin;Victor G.Kartsev;Dmitry A.Skvortsov;Alexey V.Chemeris;Alexey Kh.Baimiev;Alina A.Sofronova;Alexander S.Malyshev;Gleb I. Filkov; Dmitry S.Bezrukov;Bogdan A.Zagribelnyy;Evgeny O. Putin; Maria M.Puchinina;Olga A. Dontsova
PMC ID: PMC6719509 | DOI: 10.3389/fphar.2019.00913 |Journal: Frontiers in Pharmacology, 10(1) | Publisher: Frontiers Media S.A. |Publication date: 2019-08-27
Originaldocument: PMC | Score: 17.583435 | Text size: 67557 | Find: similardocuments
In general,we used two collections of commercially available compounds by ChemDiv andIBS. WhileChemDiv stock mainly contains organic compounds ofsynthetic origin, IBS basically focuses on nature-based ... These moleculeswere randomly selected and purchased from ChemDiv and IBScollections.
High‐
PMC ID: PMC6771893 | DOI: 10.1002/anie.201900055 |ISSN: 1433-7851 | Journal: Angewandte Chemie (International Ed. in English),58(1) pp. 12750-12760 | Publisher: John Wileyand Sons Inc. | Publicationdate: 2019-07-17 | Print publication date: 2019-09-09
Originaldocument: PMC | Score: 14.426556 | Text size: 49031 | Find: similardocuments
group,initial hits against O‐GlcNAc transferase from an expanded version of the the commercial ChemDivlibrary21were diversified through combinatorial chemistry based on a conserved
A Ligand-Based Virtual Screening Method Using Direct Quantification ofGeneralization Ability
PMC ID: PMC6651094 | DOI: 10.3390/molecules24132414 |Journal: Molecules, 24(1) | Publisher: MDPI | Publication date: 2019-06-30
Originaldocument: PMC | Score: 14.74994 | Text size: 37243 | Find: similardocuments
All the testcompounds were bought from ChemDiv (San Diego, CA, USA).
Yuan Meng; Changwei Liu; Lei Shen; Mian Zhou; Wenpeng Liu; Claudia Kowolik; Judith LCampbell;Li Zheng; Binghui Shen
PMC ID: PMC6698806 | DOI: 10.1093/nar/gkz537 |ISSN: 0305-1048 | Journal: Nucleic Acids Research, 47(1) pp. 7564-7579 |Publisher:OxfordUniversity Press | Publicationdate: 2019-06-19 | Print publication date: 2019-08-22
Originaldocument: PMC | Score: 13.76273 | Text size: 62685 | Find: similardocuments
The TRAF6 E3ligase inhibitor C25–140 (ChemDiv, Catalog #G827–0140) was added for 48h at a final concentration of 30 μM.
Laura Abriola; Denton Hoyer; Conor R. Caffrey; David L.Williams;Timothy P.Yoshino;Jon J. Vermeire; Josué deMoraes
PMC ID: PMC6546214 | DOI: 10.1371/journal.pone.0217019 |Journal: PLoS ONE, 14(1) | Publisher: PublicLibrary of Science | Publicationdate: 2019-06-03
Originaldocument: PMC | Score: 14.618862 | Text size: 29332 | Find: similardocuments
Small MW,ChemBridge DiverSet, Enzo kinase inhibitor, Yale Compounds, MicroSourcePharmakon 1600,ChemDiv Diversity, Rainforest Endophyte Extracts)were screened against A. ceylanicum eggs in our egg hatch
Chad H. G. Allen; Lewis H. Mervin; Samar Y. Mahmoud; Andreas Bender
PMC ID: PMC6544914 | DOI: 10.1186/s13321-019-0356-5 |Journal: Journal of Cheminformatics, 11(1)
Originaldocument: PMC | Score: 16.524874 | Text size: 84316 | Find: similardocuments
with the“reactive, unstable, toxic” endpoint, which includes structural alerts definedby ChemDiv, LifeChemicals and Enamine used for their internalcompound selection purposes, which was also ... propane and cyclopropane 25.13.1 × 10−5 Life chemicals TA567 Thioureas 25.1 3.1 ×10−5 ChemDiv TA885 Life chemicals TA1075 Ontarioinstitute for cancer research TA914 Nitrosos 16.
Akiko Suzuki; Sachin Puri; Pamela Leland; Ankit Puri; Tarsem Moudgil; Bernard A. Fox; Raj K. Puri; Bharat H. Joshi; Aamir Ahmad
PMC ID: PMC6532891 | DOI: 10.1371/journal.pone.0217131 |Journal: PLoS ONE, 14(1) | Publisher: PublicLibrary of Science | Publicationdate: 2019-05-23
Originaldocument: PMC | Score: 13.878843 | Text size: 55081 | Find: similardocuments
(SMI-Compound2825–0090, N-(3-carboxy-4-hydroxy) phenyl 1–2,5,-dimethylpyrole) was purchasedfromChemDiv (San Diego, CA) and dissolved in PBS for treating theNSCLC and normal lung cell lines.
Novel chemical starting points for drug discovery in leishmaniasis andChagas disease
Irene Roquero; Juan Cantizani; Ignacio Cotillo; M. Pilar Manzano; Albane Kessler; J. JulioMartín; Case W. McNamara
PMC ID: PMC6545338 | DOI: 10.1016/j.ijpddr.2019.05.002 |Journal: International Journal for Parasitology: Drugs and DrugResistance, 10(1) pp. 58-68 | Publisher: Elsevier | Publication date: 2019-05-22
Originaldocument: PMC | Score: 13.76273 | Text size: 72868 | Find: similardocuments
the screencompounds. 76 T. cruzi hits and 63 L. donovani hits were available for resupplyfrom ChemDiv and Life Chemicals.
Trevor Selwood; Brian J. Larsen; Charlie Y. Mo; Matthew J.Culyba;Zachary M.Hostetler;Rahul M. Kohli; Allen B. Reitz; Simon D. P. Baugh
PMC ID: PMC6305444 | DOI: 10.3389/fmicb.2018.02961 |Journal: Frontiers in Microbiology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-12-18
Originaldocument: PMC | Score: 14.2392435 | Text size: 51939 | Find: similardocuments
Analogswhich were not synthesized were obtained from commercial vendors ChemDiv (SanDiego, CA, United States) and Vitas-M Laboratory (Champagne, IL).
Valerio Ciccone; Erika Terzuoli; Sandra Donnini; AntonioGiachetti;Lucia Morbidelli; Marina Ziche
PMC ID: PMC6291966 | DOI: 10.1186/s13046-018-0975-0 |ISSN: 0392-9078 | Journal: Journal of Experimental & Clinical Cancer Research: CR, 37(1) | Publisher: BioMedCentral | Publicationdate: 2018-12-12
Originaldocument: PMC | Score: 13.536236 | Text size: 64085 | Find: similardocuments
MethodsChemicals and reagents The ALDH1A1 selective inhibitor CM037 was from ChemDivInc. (San Diego, CA, USA).
Inhibition of CPAP–tubulin interaction prevents proliferation ofcentrosome‐
AruljothiMariappan;Komal Soni; Kenji Schorpp; Fan Zhao; Amin Minakar; Xiangdong Zheng; Sunit Mandad; Iris Macheleidt; Anand Ramani; TomášKubelka;MaciejDawidowski;KristinaGolfmann;Arpit Wason; Chunhua Yang; Judith Simons; Hans
PMC ID: PMC6331730 | DOI: 10.15252/embj.201899876 |ISSN: 0261-4189 | Journal: The EMBO Journal, 38(1) | Publisher: John Wileyand Sons Inc. | Publicationdate: 2018-12-10 | Print publication date: 2019-01-15
Originaldocument: PMC | Score: 12.700202 | Text size: 117793 | Find: similardocuments
in the CPAP
Jessica M.Morgan;Hanh N. Lam; Jocelyn Delgado; Justin Luu; Sina Mohammadi; Ralph R. Isberg; Helen Wang; VictoriaAuerbuch
PMC ID: PMC6262202 | DOI: 10.3389/fcimb.2018.00404 |Journal: Frontiers in Cellular and Infection Microbiology, 8(1) | Publisher: FrontiersMedia S.A. | Publicationdate: 2018-11-22
Originaldocument: PMC | Score: 13.996932 | Text size: 65275 | Find: similardocuments
INP0010(CAS# 68639-26-9) was obtained from ChemDiv.
QSAR-Based Virtual Screening: Advances and Applications in Drug Discovery
Bruno J. Neves; Rodolpho C.Braga;Cleber C.Melo-Filho;JoséTeófilo Moreira-Filho; Eugene N.Muratov;Carolina HortaAndrade
PMC ID: PMC6262347 | DOI: 10.3389/fphar.2018.01275 |Journal: Frontiers in Pharmacology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-11-13
Originaldocument: PMC | Score: 14.74994 | Text size: 33091 | Find: similardocuments
data wereused to develop QSAR models and, then, applied to screen near 700,000 compoundsfromChemDiv database.
Discovery of a Novel Microtubule Targeting Agent as an Adjuvant forCancer Immunotherapy
Fumi Sato-Kaneko; Xiaodong Wang; Shiyin Yao; Tadashi Hosoya; Fitzgerald S.Lao;Karen Messer; Minya Pu; Nikunj M. Shukla; Howard B. Cottam;Michael Chan; Dennis A. Carson; Maripat Corr; Tomoko Hayashi
PMC ID: PMC6199861 | DOI: 10.1155/2018/8091283 |ISSN: 2314-6133 | Journal: BioMed Research International, 2018(1) | Publisher:Hindawi | Publication date: 2018-10-10
Originaldocument: PMC | Score: 13.996932 | Text size: 52535 | Find: similardocuments
Othercompounds were purchased from ChemBridge Corporation and ChemDiv andwere verified for purity (>98%) by LC-MS.
Correcting glucose-6-phosphate dehydrogenase deficiency with asmall-molecule activator
Sunhee Hwang; Karen Mruk; Simin Rahighi; Andrew G. Raub; Che-Hong Chen; Lisa E. Dorn; Naoki Horikoshi; Soichi Wakatsuki; James K. Chen;DariaMochly-Rosen
PMC ID: PMC6168459 | DOI: 10.1038/s41467-018-06447-z |Journal: Nature Communications, 9(1) | Publisher: NaturePublishing Group UK |Publication date: 2018-10-02
Originaldocument: PMC | Score: 13.536236 | Text size: 71259 | Find: similardocuments
All thecompounds purchased from SPECS, Chembridge, ChemDiv Kinase,LOPAC, Microsource Spectrum, Biomol FDA, Biomol ICCB, and NIH ClinicalCollection were
MartynaPlens-Galaska; MalgorzataSzelag;Aida Collado; Patrice Marques; Susana Vallejo; MariellaRamos-González; Joanna Wesoly; MaríaJesus Sanz;ConcepciónPeiró; Hans A. R.Bluyssen
PMC ID: PMC6156247 | DOI: 10.3389/fimmu.2018.02141 |Journal: Frontiers in Immunology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-09-19
Originaldocument: PMC | Score: 12.700202 | Text size: 108167 | Find: similardocuments
C01 andC01L_A03-C01L_F03 were purchased from Enamine; E01 from Asinex; F01 from ChemDiv;STX-0119 from Merck and STATTIC from Sigma-Aldrich.
Small molecules that target group II introns are potent antifungal agents
Olga Fedorova; G. Erik Jagdmann; Rebecca L. Adams; Lin Yuan; Michael C. VanZandt;Anna Marie Pyle
PMC ID: PMC6239893 | DOI: 10.1038/s41589-018-0142-0 |ISSN: 1552-4450 | Journal: Nature chemical biology, 14(1) pp. 1073-1078 |Publication date: 2018-09-07 | Print publication date: 2018-12
Originaldocument: PMC | Score: 13.878843 | Text size: 58425 | Find: similardocuments
(76compounds), protease inhibitors (53 compounds) and additional compounds fromChemBridge MW andChemDiv to bring the total number of compounds to 10000.
ObdulioGarcía-Nicolás; Philip V'kovski; Nathalie J.Vielle;Nadine Ebert; Roland Züst; Jasmine Portmann; HanspeterStalder;VéroniqueGaschen;GabrielleVieyres;Michael Stoffel; MatthiasSchweizer;ArturSummerfield;Olivier Engler; ThomasPietschmann;Daniel Todt; Marco P. Alves;Volker Thiel; StephaniePfaender
PMC ID: PMC6201103 | DOI: 10.1128/AAC.01206-18 |ISSN: 0066-4804 | Journal: Antimicrobial Agents and Chemotherapy, 62(1)
Originaldocument: PMC | Score: 13.648543 | Text size: 65154 | Find: similardocuments
benzamide)was purchased from ChemDiv (catalog number 4295-0370; SanDiego, CA) and DMSO.
The TMEM16A channel mediates the fast polyspermy block in Xenopus laevis
Katherine L.Wozniak;Wesley A. Phelps; Maiwase Tembo; Miler T. Lee; Anne E. Carlson
PMC ID: PMC6122928 | DOI: 10.1085/jgp.201812071 |ISSN: 0022-1295 | Journal: The Journal of General Physiology, 150(1) pp.1249-1259 |Publisher: Rockefeller University Press | Publicationdate: 2018-09-03 | Print publication date: 2018-09-03
Originaldocument: PMC | Score: 14.2392435 | Text size: 54256 | Find: similardocuments
and 2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide(Ani9) from ChemDiv.
Lingyan Wang; Tianqing Song; Xin Wang; Jiazhong Li
PMC ID: PMC6121070 | DOI: 10.3389/fphar.2018.00864 |Journal: Frontiers in Pharmacology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-08-28
Originaldocument: PMC | Score: 18.165255 | Text size: 48086 | Find: similardocuments
Then the ARcrystal structure (PDB ID:1T65) and Anti-AR were both used to virtually screenthe ChemDivdatabase by using Glide standard precision (SP) dockingprogram. Glide SP, a semi flexible docking method, performs exhaustive samplingand is the recommended balance between speed and accuracy. ChemDiv isnow the recognized global leader in discovery chemistry with the industry'slargest, most ... regression (MLR) method were employed to in silico evaluatethe bioactivities of the filtered ChemDiv chemicals containedin database 2. The development and validation of QSAR models The linear MLR ...preparation Considering the diversity of the molecular structure, thecommercially available ChemDiv structural library(http://www.chemdiv.
A metabolite-derived protein modification integrates glycolysis withKEAP1-NRF2 signaling
Michael J.Bollong;Gihoon Lee; John S. Coukos; Hwayoung Yun; Claudio Zambaldo; Jae Won Chang; Emily N. Chin; Insha Ahmad; Arnab K.Chatterjee;Luke L. Lairson; Peter G. Schultz; Raymond E.Moellering
PMC ID: PMC6444936 | DOI: 10.1038/s41586-018-0622-0 |ISSN: 0028-0836 | Journal: Nature, 562(1) pp. 600-604 |Publicationdate: 2018-08-28 | Print publication date: 2018-10
Originaldocument: PMC | Score: 15.963614 | Text size: 82825 | Find: similardocuments
CBR-470-0and CBR-581-9 were from ChemDiv. CBR-470-1 (initially from ChemDiv asD470-2172) and related analogs were synthesized in house according to fullmethods described in
Ji Yeon Choi; In Jun Yeo; Ki Cheon Kim; Won Rack Choi; Jae-Kyung Jung; Sang-Bae Han; Jin Tae Hong
PMC ID: PMC6087013 | DOI: 10.1186/s12974-018-1269-3 |Journal: Journal of Neuroinflammation, 15(1)
Originaldocument: PMC | Score: 13.878843 | Text size: 52408 | Find: similardocuments
(K284-6111)and other chemicals were obtained from ChemDiv, Inc. (Cat No.3292320, San Diego, CA).
Targeting the Microenvironment in High Grade Serous Ovarian Cancer
Nkechiyere G.Nwani;Livia E. Sima; WilbertoNieves-Neira; Daniela Matei
PMC ID: PMC6115937 | DOI: 10.3390/cancers10080266 |Journal: Cancers, 10(1) | Publisher: MDPI | Publication date: 2018-08-10
Originaldocument: PMC | Score: 13.42576 | Text size: 89735 | Find: similardocuments
efforts usedan AlphaLISA-based assay adapted to high-throughput screening and applied tothe ChemDivlibrary leading to the discovery and validation ofseveral small molecules [126].
Insights into the development of chemical probes for RNA
Brittany SMorgan;Jordan E Forte; Amanda EHargrove
PMC ID: PMC6144806 | DOI: 10.1093/nar/gky718 |ISSN: 0305-1048 | Journal: Nucleic Acids Research, 46(1) pp. 8025-8037 |Publisher:OxfordUniversity Press | Publicationdate: 2018-08-08 | Print publication date: 2018-09-19
Originaldocument: PMC | Score: 14.2392435 | Text size: 66141 | Find: similardocuments
Recently,chemical companies have designed such focused libraries (ChemDiv,Nucleic Acid Ligands: http://www.chemdiv.
Biaryl sulfonamide motifs up- or down-regulate ion channel activity byactivating voltage sensors
Sara I. Liin; Per-Eric Lund; Johan E. Larsson; Johan Brask; BjörnWallner;Fredrik Elinder
PMC ID: PMC6080886 | DOI: 10.1085/jgp.201711942 |ISSN: 0022-1295 | Journal: The Journal of General Physiology, 150(1) pp.1215-1230 |Publisher: Rockefeller University Press | Publicationdate: 2018-08-06 | Print publication date: 2018-08-06
Originaldocument: PMC | Score: 14.2392435 | Text size: 60672 | Find: similardocuments
ConsortiumSweden)*; Natural derivatives (TimTec); NIH Clinical Collection (NIH);Peptidomimetics (ChemDiv Inc.)*; and Tocriscreen Plus (Tocris Bioscience).
Identification of a novel c-Myc inhibitor with antitumor effects onmultiple myeloma cells
Ruosi Yao; Xiaoyang Sun; Yu Xie; Xiaoshen Sun; Yao Yao; Hujun Li; Zhenyu Li; Jian Gao; Kailin Xu
PMC ID: PMC6146296 | DOI: 10.1042/BSR20181027 |ISSN: 0144-8463 | Journal: Bioscience Reports, 38(1) | Publisher: PortlandPress Ltd. |Publication date: 2018-08-01
Originaldocument: PMC | Score: 17.709631 | Text size: 28027 | Find: similar documents
It wasidentified from the ChemDiv compound database by moleculardocking-based, high-throughput virtual screening. ... The ChemDiv database,a commercially available small molecule database from TopScience Co. ...Because only 2D-structural information was available, all compounds inthe ChemDiv database were preprocessed by using the dbtranslate module in Sybyl-X2.
Victoria Easton; Martin McPhillie; IsabelGarcia-Dorival; John N. Barr; Thomas A.Edwards;Richard Foster; Colin Fishwick; Mark Harris
PMC ID: PMC6371959 | DOI: 10.1016/j.antiviral.2018.06.003 |ISSN: 0166-3542 | Journal: Antiviral Research, 156(1) pp. 46-54 |Publisher:Elsevier | Publication date: 2018-08-01 | Print publication date: 2018-08
Originaldocument: PMC | Score: 17.646307 | Text size: 42059 | Find: similardocuments
Dry stocksof the original compounds were later purchased from the original supplier (ChemDiv)to confirm initial biological activity. Follow-up compounds were purchased fromChemBridge or ChemDiv and shipped as dry stocks. ...structural derivatives, where particular functional groups had been modified,were purchased (from ChemDiv Inc) and a further eight ChemBridgeanalogues were identified using the programme ROCS (rapid overlay
Mohd. Babu Khan; Bhagath KumarPalaka;Tuleshwori DeviSapam;Naidu Subbarao; Dinakara RaoAmpasala
PMC ID: PMC6166398 | DOI: 10.6026/97320630014414 |Journal: Bioinformation, 14(1) pp. 414-428 | Publisher: BiomedicalInformatics |Publication date: 2018-08
Originaldocument: PMC | Score: 19.113825 | Text size: 36455 | Find: similardocuments
Ligandlibrary preparation A library of 23,731 CNS_BBB compounds was obtained fromthe ChemDiv database (http://www.chemdiv.com/cns-bbblibrary/)[21]. CNS-BBB ChemDiv database compound is a known asantioxidant and anti-inflammatory nature, and the 2D structures in Sdf formatwere downloaded from theChemDiv database, and created a 3D-Phasedatabase from Phase module of the Schrodinger, phase version 3.2. ...Discussion Based on this CNS-BBB, Standard Data Format (SDF) data, provided bythe ChemDiv Data base server, finding the top three ligandinhibitors as M1, M8, and M10 shows a good ... -204.27+/-50.94 -214.40 +/12.67Table 3 ADMET Property profile of the top ten hits of CNS-BBB of ChemDiv databasecompounds Compound Ida Molecular Weight1 SASA2 QPLogS3 QPlog- HERG4 QPlog-BB5 %HOA6
Frizzled-8 integrates Wnt-11 and transforming growth factor-
VirginiaMurillo-Garzón; IrantzuGorroño-Etxebarria; MalinÅkerfelt; Mikael ChristerPuustinen;Lea Sistonen; Matthias Nees; James Carton;Jonathan Waxman; Robert M. Kypta
PMC ID: PMC5931552 | DOI: 10.1038/s41467-018-04042-w |Journal: Nature Communications, 9(1) | Publisher: NaturePublishing Group UK |Publication date: 2018-05-01
Originaldocument: PMC | Score: 13.104898 | Text size: 82903 | Find: similardocuments
Inhibitor 1(3235-0367) and 2 (2124-0331), which were obtained from ChemDiv Inc. (CA,USA) were used at 10 μM for 24 hin migration assays.
Small molecule KDM4s inhibitors as anti-cancer agents
Hongzhi Lin; Qihang Li; Qi Li; Jie Zhu; Kai Gu; Xueyang Jiang; Qianqian Hu; Feng Feng; Wei Qu; Yao Chen; Haopeng Sun
PMC ID: PMC6010108 | DOI: 10.1080/14756366.2018.1455676 |ISSN: 1475-6366 | Journal: Journal of Enzyme Inhibition and Medicinal Chemistry,33(1) pp. 777-793 | Publisher: Taylor &Francis | Publicationdate: 2018-04-13
Originaldocument: PMC | Score: 13.536236 | Text size: 76162 | Find: similardocuments
A moleculardocking-based virtual screening against various chemical libraries includeSpecs and ChemDivwas performed to retrieve two compounds withmodest inhibition rate against KDM4D (> 50% at 10 μM).
High Performance Virtual Screening by Targeting a High-resolution RNADynamic Ensemble
Laura R. Ganser; Janghyun Lee; Atul Rangadurai; Dawn K. Merriman; Megan L. Kelly; Aman D. Kansal; BharathwajSathyamoorthy; Hashim M.Al-Hashimi
PMC ID: PMC5942591 | DOI: 10.1038/s41594-018-0062-4 |ISSN: 1545-9993 | Journal: Nature structural & molecular biology, 25(1) pp.425-434 | Publication date: 2018-04-05 | Print publication date: 2018-05
Originaldocument: PMC | Score: 14.117049 | Text size: 66856 | Find: similardocuments
Michigan,Ann Arbor. 100,000 molecules were synthetic organic molecules with drug-likeproperties (ChemDiv). The other 3,498 compounds consisted of 2,000bioactive molecules (MicroSource Discovery Systems
StrahinjaStevanović; Andrej Perdih; MilanSenćanski; SanjaGlišić; Margarida Duarte; Ana M.Tomás; Filipa V. Sena; Filipe M. Sousa; Manuela M.Pereira;Tom Solmajer; Thomas J.Schmidt
PMC ID: PMC6017605 | DOI: 10.3390/molecules23040772 |Journal: Molecules : A Journal of Synthetic Chemistry andNatural Product Chemistry, 23(1) | Publisher: MDPI | Publication date: 2018-03-27
Originaldocument: PMC | Score: 14.301138 | Text size: 49462 | Find: similardocuments
of 500,000commercially available compounds originating from different vendors (e.g.,VITAS-M, ChemDiv, ChemBridge, etc.
Computer-Aided Drug Design in Epigenetics
Wenchao Lu; Rukang Zhang; Hao Jiang; Huimin Zhang; Cheng Luo
PMC ID: PMC5857607 | DOI: 10.3389/fchem.2018.00057 |Journal: Frontiers in Chemistry, 6(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-03-12
Originaldocument: PMC | Score: 13.42576 | Text size: 116979 | Find: similar documents
LSD1; PRMT5ChEMBL ~1.7 million http://www.ebi.ac.uk/chembldb/index.php GCN5; BRD4 ChemDiv ~1.5million http://www.chemdiv.
Shaherin Basith; Minghua Cui; Stephani J. Y.Macalino;Jongmi Park; Nina A. B.Clavio;Soosung Kang; Sun Choi
PMC ID: PMC5854945 | DOI: 10.3389/fphar.2018.00128 |Journal: Frontiers in Pharmacology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-03-09
Originaldocument: PMC | Score: 16.120045 | Text size: 112002 | Find: similardocuments
Kruse etal., 2013 Ki=1.2 uM A, nonrhodopsin (lipid-like) CB2R Enamine, Otava,ChemBridge, ChemDiv, Vitasm, IBS, LifeChemicals, Specs, and TimTec:5,613,820 compounds 13 hits ≥ 50% inhibition at 10 ... 80,700https://www.keyorganics.net ChemBridge 1,100,000 Yhttp://www.chembridge.com ChemDiv 1,500,000 Yhttp://www.chemdiv.com CoCoCo 6,981,500 http://cococo.isof.cnr.
Virtual Screening of Small Molecular Inhibitors against DprE1
Gang Zhang; Song Guo; Huaqing Cui; Jianguo Qi
PMC ID: PMC6017230 | DOI: 10.3390/molecules23030524 |Journal: Molecules : A Journal of Synthetic Chemistry andNatural Product Chemistry, 23(1) | Publisher: MDPI | Publication date: 2018-02-27
Originaldocument: PMC | Score: 18.638195 | Text size: 23102 | Find: similardocuments
Weidentified potential DprE1 inhibitors from the ChemDiv datasetthrough virtual screening based on pharmacophore and molecular docking. ...Results and Discussion The ChemDiv is the industry’s largest,most diverse, and most pharmacologically-relevant commercial collection, ...Preparation for Virtual Screening TheChemDiv dataset containing1.96 million compounds was downloaded from the ZINC database [11]. ... FirstRound of Screening Based on Oprea’s Lead-Likeness Criteria The ChemDiv dataset,containing 1,962,494 compounds, was filtered to exclude compounds that did notfollow ... We identified DprE1 inhibitors from theChemDiv datasetthrough virtual screening based on pharmacophore and molecular docking.
Ying Fu; Yi-Na Sun; Ke-Han Yi; Ming-Qiang Li; Hai-Feng Cao; Jia-Zhong Li; Fei Ye
PMC ID: PMC5807903 | DOI: 10.3389/fchem.2018.00014 |Journal: Frontiers in Chemistry, 6(1) | Publisher: FrontiersMedia S.A. |Publication date: 2018-02-06
Originaldocument: PMC | Score: 18.863625 | Text size: 48724 | Find: similardocuments
pharmacophoremodel was used as a 3D query for searching four databases (Maybridge,Chembridge,ChemDiv, and Specs) to discern novel HPPD inhibitors and alsoutilized as a predictive program to estimate ... Subsequently, Chembridge,Maybridge, ChemDiv and Specs were selected as “Input Database”and Hypo1 was imported to “Input Pharmacophore” to ... as a 3D query tool toscreen the chemical databases like Maybridge (20565), Chembridge (40637), ChemDiv (12620),and Specs (37738). ... As a result, 643, 392, 416, and 466 (a total of 1917)compounds from Maybridge, Chembridge, ChemDiv and Specs, weremapped upon all the features of Hypo1.
QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species
Byoung Sik Kim; Song Yee Jang; Ye-ji Bang; Jungwon Hwang; Youngwon Koo; Kyung Ku Jang; Dongyeol Lim; Myung Hee Kim; Sang Ho Choi; E. PeterGreenberg
PMC ID: PMC5790914 | DOI: 10.1128/mBio.02262-17 |Journal: mBio, 9(1) | Publisher: AmericanSociety for Microbiology | Publicationdate: 2018-01-30
Originaldocument: PMC | Score: 13.996932 | Text size: 72030 | Find: similardocuments
Hitmolecules were either purchased from ChemDiv (San Diego, CA)or synthesized as described below.
Rahila Rahimova; Simon Fontanel; Corinne Lionne; Lars PeterJordheim;SuzannePeyrottes;Laurent Chaloin; AvnerSchlessinger
PMC ID: PMC5805337 | DOI: 10.1371/journal.pcbi.1005943 |ISSN: 1553-734X | Journal: PLoS Computational Biology, 14(1)
Originaldocument: PMC | Score: 13.76273 | Text size: 68647 | Find: similardocuments
was composedof unique molecules, commercially available from several main suppliers(Asinex, ChemDiv Inc., Vitas-M laboratory and Enamine).
NMR-Fragment Based Virtual Screening: A Brief Overview
Meenakshi Singh; Benjamin Tam; Barak Akabayov
PMC ID: PMC6017141 | DOI: 10.3390/molecules23020233 |Journal: Molecules : A Journal of Synthetic Chemistry andNatural Product Chemistry, 23(1) | Publisher: MDPI | Publication date: 2018-01-25
Originaldocument: PMC | Score: 13.996932 | Text size: 94229 | Find: similardocuments
1500Modified Ro3 compliant Kinase focused fragment library 500 19F labeled fragmentlibrary 500 ChemDiv3D designed fragment library >4000 Ro3compliant Enamine “Simple” fragment library 126,597 Ro3
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Brent D. G. Page; Nicholas C. K.Valerie;Roni H. G.Wright;Olov Wallner; Rebecka Isaksson; Megan Carter; Sean G. Rudd; Olga Loseva; Ann-Sofie Jemth; IngridAlmlöf;Jofre Font-Mateu; SabinLlona-Minguez; PawelBaranczewski; Fredrik Jeppsson; Evert Homan; Helena Almqvist; Hanna Axelsson; Shruti Regmi; Anna-LenaGustavsson;ThomasLundbäck; Martin Scobie; KiaStrömberg; PålStenmark;Miguel Beato; Thomas Helleday
PMC ID: PMC5772648 | DOI: 10.1038/s41467-017-02293-7 |Journal: Nature Communications, 9(1) | Publisher: NaturePublishing Group UK |Publication date: 2018-01-17
Originaldocument: PMC | Score: 13.317075 | Text size: 78980 | Find: similardocuments
(CBCS)primary screening set and several commercial libraries from Enamine, TimTec,Maybridge andChemDiv.
Leila Saxby Ross; MariaJosé Lafuente-Monasterio; TomoyoSakata-Kato;Rebecca E. K.Mandt;Francisco JavierGamo;Dyann F. Wirth; Amanda K. Lukens
PMC ID: PMC5899019 | DOI: 10.1021/acsinfecdis.7b00217 |Journal: ACS Infectious Diseases, 4(1) pp. 508-515 |Publisher: American Chemical Society | Publicationdate: 2018-01-16 | Print publication date: 2018-04-13
Originaldocument: PMC | Score: 14.426556 | Text size: 40292 | Find: similardocuments
IDI-6273 waspurchased from ChemDiv.
Ji Min Oh; SenthilkumarKalimuthu;Prakash Gangadaran; Se Hwan Baek; Liya Zhu; Ho Won Lee; Ramya LakshmiRajendran;Chae Moon Hong; Shin Young Jeong; Sang-Woo Lee; Jaetae Lee; Byeong-Cheol Ahn
PMC ID: PMC5805537 | DOI: 10.18632/oncotarget.24159 |Journal: Oncotarget, 9(1) pp. 7075-7087 |Publisher: Impact Journals LLC |Publication date: 2018-01-11
Originaldocument: PMC | Score: 14.117049 | Text size: 45448 | Find: similardocuments
K905-0266TKI was purchased from ChemDiv (San Diego, CA, USA) anddissolved in dimethyl sulfoxide (DMSO) and stored at −80°C.
Kallikrein-related peptidase 7 is a potential target for the treatment ofpancreatic cancer
Jian Ping Du; Lin Li; Jun Zheng; Ding Zhang; Wei Liu; Wei Hong Zheng; Xiao Song Li; Ru Cheng Yao; Fangyu Wang; Sen Liu; Xiao Tan
PMC ID: PMC5849182 | DOI: 10.18632/oncotarget.24132 |Journal: Oncotarget, 9(1) pp. 12894-12906 | Publisher: Impact Journals LLC |Publication date: 2018-01-10
Originaldocument: PMC | Score: 16.44229 | Text size: 45197 | Find: similardocuments
In silicoscreening of novel KLK7 inhibitors The 1,044,623 molecules in the ChemDiv databasewere prepared in Pipeline Pilot to generate 3-D conformations and minimized(Figure 5). ... Experimental validation of novel KLK7 inhibitors The 300compounds purchased from the ChemDiv library were evaluatedfor the in vitro inhibition of KLK7 by measuring the hydrolysis of the FRET
Jiahui Cao; Manuel Ehling; Sigrid März; Jochen Seebach; KatsiarynaTarbashevich; Tomas Sixta; Mara E.Pitulescu;Ann-CathrinWerner;Boris Flach;Eloi Montanez; Erez Raz; Ralf H. Adams; Hans Schnittler
PMC ID: PMC5738342 | DOI: 10.1038/s41467-017-02373-8 |Journal: Nature Communications, 8(1) | Publisher: NaturePublishing Group UK |Publication date: 2017-12-20
Originaldocument: PMC | Score: 13.104898 | Text size: 94651 | Find: similardocuments
purchasedfrom Calbiochem (Bad Soden, Germany), and the active inhibitor CK548 waspurchased fromChemDiv (#K205-1650, San Diego, USA). Regents were usedat concentrations as indicated in the text.
Paul A Nakamura; Andy A Shimchuk; Shibing Tang; Zhizhi Wang; Kole DeGolier; Sheng Ding; Thomas A Reh; Jeremy Nathans
PMC ID: PMC5693111 | DOI: 10.7554/eLife.30577 |Journal: eLife, 6(1) | Publisher: eLifeSciences Publications, Ltd | Publicationdate: 2017-11-17
Originaldocument: PMC | Score: 17.52101 | Text size: 49512 | Find: similardocuments
LaboratoryJackson Stock No: 000664; RRID:IMSR_JAX:000664 Chemical compound Photoregulin3(PR3)ChemDiv, and then synthesized in Ding Lab PubChem CID: 2092851Chemical compound Photoregulin1 (PR1)ChemDiv, and then synthesized inDing Lab PubChem CID: 7901316 Antibody Anti- Rhodopsin (Rho4D2), mouse ... Itwas initially obtained from ChemDiv and then synthesized andpurified in large quantities in the lab after initial screening.
Yoav Elkis; Moshe Cohen; Etai Yaffe; ShirlySatmary-Tusk; Tal Feldman; Elad Hikri; Abraham Nyska; Ariel Feiglin; Yanay Ofran; Sally Shpungin; Uri Nir
PMC ID: PMC5643328 | DOI: 10.1038/s41467-017-00832-w |Journal: Nature Communications, 8(1) | Publisher: Nature Publishing Group UK |Publication date: 2017-10-16
Originaldocument: PMC | Score: 15.367116 | Text size: 95412 | Find: similardocuments
robot, andapplied for screening a library comprised of 100,000 synthetic compounds (ChemDiv,USA). ... E260 was also computationally analyzed using the ChemSoft software (ChemDiv,USA) and proven to possess drug-likeness according to the Lipinski’s rule of 561.
Che-Ming Jack Hu; Wei-Shan Chang; Zih-Syun Fang; You-Ting Chen; Wen-Lin Wang; Hsiao-Han Tsai; Ling-Ling Chueh; Tomomi Takano; Tsutomu Hohdatsu; Hui-Wen Chen
PMC ID: PMC5638965 | DOI: 10.1038/s41598-017-13316-0 |Journal: Scientific Reports, 7(1) | Publisher: NaturePublishing Group UK |Publication date: 2017-10-12
Originaldocument: PMC | Score: 13.996932 | Text size: 51246 | Find: similardocuments
Diphyllinand diphyllin-encapsulated nanoparticles Diphyllin (ChemDiv, San Diego,CA) and bafilomycin A1 (Sigma) were dissolved in dimethyl sulfoxide (DMSO,Sigma).
Xi Chen; Chun Xie; Xing-Xing Fan; Ze-Bo Jiang; Vincent Kam-WaiWong;Jia-Hui Xu; Xiao-Jun Yao; Liang Liu; Elaine Lai-HanLeung
PMC ID: PMC5707083 | DOI: 10.18632/oncotarget.21716 |Journal: Oncotarget, 8(1) pp. 96089-96102 | Publisher: Impact Journals LLC |Publication date: 2017-10-09
Original document: PMC | Score: 13.878843 | Text size: 55446 | Find: similardocuments
MATERIALSAND METHODS Materials The compound library consisting 74 compounds werepurchased fromChemDiv (San Diego, CA, USA).
Eicosapentaenoic acid and 5-HEPE enhance macrophage-mediated Treginduction in mice
ToshiharuOnodera;AtsunoriFukuhara;Jihoon Shin; TomonoriHayakawa;Michio Otsuki; IichiroShimomura
PMC ID: PMC5496870 | DOI: 10.1038/s41598-017-04474-2 |Journal: Scientific Reports, 7(1) | Publisher: NaturePublishing Group UK |Publication date: 2017-07-04
Originaldocument: PMC | Score: 13.996932 | Text size: 45088 | Find: similardocuments
GPR119antagonist TM43718 was purchased as E897-0145 from ChemDiv (SanDiego, CA, USA).
Tonghui Huang; Jie Sun; Shanshan Zhou; Jian Gao; Yi Liu
PMC ID: PMC5535900 | DOI: 10.3390/ijms18071408 |Journal: International Journal of Molecular Sciences, 18(1)
Originaldocument: PMC | Score: 18.617102 | Text size: 32937 | Find: similardocuments
A chemicallibrary containing with 1,500,000 commercially available compounds (ChemDiv database)was docked to the molecular models of α1β1γ1 and α2β1γ1 AMPKisoforms in silico, respectively. Prior to docking, the ChemDiv databasewas split into eight subsets for molecular docking. ... The ChemDiv databasewas supplied by Topscience Co. ... Figure 5 Structures of retrieved hitstargeting α1β1γ1 AMPK isoformfromChemDiv database. Figure 6 The binding modes of typical hitcompounds for α1β1γ1 AMPKisoform. ... Figure 7 Structures of retrieved hits targeting α2β1γ1 AMPKisoform from ChemDiv database. Figure 8 The binding modes oftypical activators for α2β1γ1 AMPKisoform.
Identification of benzazole compounds that induce HIV-1 transcription
Jason D. Graci; Daniel Michaels; Guangming Chen; Gillian M.Schiralli Lester; Sarah Nodder; Marla Weetall; Gary M. Karp; Zhengxian Gu; Joseph M.Colacino;Andrew J.Henderson;Fatah Kashanchi
PMC ID: PMC5489165 | DOI: 10.1371/journal.pone.0179100 |Journal: PLoS ONE, 12(1) | Publisher: PublicLibrary of Science | Publicationdate: 2017-06-28
Originaldocument: PMC | Score: 13.878843 | Text size: 63610 | Find: similardocuments
Compound 1,2-(4-(5-amino-1H-benzimidazol-2-yl)phenyl)benzoxazol-5-amine, was acquiredfrom ChemDiv(San Diego, CA). Compounds 2–6 were synthesized at PTCTherapeutics, Inc.
Ying Fu; Yi-Na Sun; Ke-Han Yi; Ming-Qiang Li; Hai-Feng Cao; Jia-Zhong Li; Fei Ye; AlessandroPedretti
PMC ID: PMC6152767 | DOI: 10.3390/molecules22060959 |Journal: Molecules : A Journal of Synthetic Chemistry andNatural Product Chemistry, 22(1) | Publisher: MDPI | Publication date: 2017-06-09
Originaldocument: PMC | Score: 19.086233 | Text size: 32321 | Find: similardocuments
The ChemDiv databasewas screened using CBP-Hypo2 as a 3D query, and the best-fit hits subjected tomolecular ... HPPD inhibitors pharmacophore model molecule docking HipHop modelvirtual screeningChemDiv 1. Introduction Weeds compete with cropsfor sunshine, water, nutrients, and space, which ... having inhibitory activityagainst HPPD based on receptor, CBP-Hypo2 was used to screen the ChemDiv libraryto find potential HPPD inhibitors and Fit Value was selected as an importantcriterion. The hydrophobic groups (benzene and methyl) of the four compoundsobtained from the ChemDiv database formed hydrophobicinteractions with Met314 and Pro205, and the intermediate aromatic ring
A covalent PIN1 inhibitor selectively targets cancer cells by a dualmechanism of action
Elena Campaner; AlessandraRustighi;AlessandroZannini;AlbertoCristiani;Silvano Piazza; Yari Ciani; Ori Kalid; Gali Golan; Erkan Baloglu; Sharon Shacham; BarbaraValsasina;Ulisse Cucchi; Agnese ChiaraPippione;Marco LucioLolli;Barbara Giabbai; Paola Storici; Paolo Carloni; Giulia Rossetti; FedericaBenvenuti;Ezia Bello; MaurizioD'Incalci;ElisaCappuzzello;Antonio Rosato; Giannino Del Sal
PMC ID: PMC5472749 | DOI: 10.1038/ncomms15772 |Journal: Nature Communications, 8(1) | Publisher: NaturePublishing Group |Publication date: 2017-06-09
Originaldocument: PMC | Score: 15.963614 | Text size: 81154 | Find: similardocuments
Bionet (www.keyorganics.co.uk),Specs (www.specs.net), Chembridge (www.chembridge.com), ChemDiv(www.chemdiv.com)and Enamine (www.enamine.net). ... measurement 15 μl of Trypsin50 mg ml−1 (Sigma) and 5 μl of Suc-AEPF-MCA peptide 100 μg ml−1 (ChemDiv)in TFE LiCl 480 mM were added and the solutions mixed.
Erica Acton; Amy Huei-Yi Lee; Pei Jun Zhao; StephaneFlibotte;Mauricio Neira; Sunita Sinha; Jennifer Chiang; Patrick Flaherty; Corey Nislow; Guri Giaever
PMC ID: PMC5493772 | DOI: 10.1098/rsob.160330 |Journal: Open Biology, 7(1) | Publisher: The RoyalSociety | Publicationdate: 2017-06-07
Originaldocument: PMC | Score: 14.490094 | Text size: 61522 | Find: similardocuments
Screeningconcentrations for each compound (cisplatin (Toronto Research Chemicals), PCID16001701 (ChemDiv), CCCP (Sigma), FCCP (Sigma)) were determined byanalysing dose–response curves on wild-type
Sarah Preston; Yaqing Jiao; Jonathan B.Baell;Jennifer Keiser; Simon Crawford; Anson V. Koehler; Tao Wang; Moana M. Simpson; Ray M. Kaplan;Karla J. Cowley; Kaylene J.Simpson;Andreas Hofmann; Abdul Jabbar; Robin B. Gasser
PMC ID: PMC5517787 | DOI: 10.1016/j.ijpddr.2017.05.004 |Journal: International Journal for Parasitology: Drugs and DrugResistance, 7(1) pp. 286-294 | Publisher: Elsevier | Publication date: 2017-05-28
Originaldocument: PMC | Score: 14.363574 | Text size: 46349 | Find: similardocuments
microfilariaeof B. malayi A compound with known activity against H. contortus was purchasedfrom ChemDiv(USA) and then dissolved in DMSO to reach a stockconcentration of 30 mM, and then tested for its
GiuseppeAllegretta;Christine K.Maurer;Jens Eberhard; Damien Maura; Rolf W. Hartmann; Laurence Rahme; Martin Empting
PMC ID: PMC5442231 | DOI: 10.3389/fmicb.2017.00924 |Journal: Frontiers in Microbiology, 8(1)
Originaldocument: PMC | Score: 14.117049 | Text size: 45945 | Find: similardocuments
Thetricyclic 3 (Figure 2) and amitriptyline were purchased from ChemDiv (UnitedStates) and Alfa Aesar (Germany), respectively.
Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity
Joseph S.Bednash;NathanielWeathington;James Londino; Mauricio Rojas; Dexter L. Gulick; Robert Fort; SeungHye Han; Alison C.McKelvey;Bill B. Chen; Rama K.Mallampalli
PMC ID: PMC5437278 | DOI: 10.1038/ncomms15203 |Journal: Nature Communications, 8(1) | Publisher: NaturePublishing Group |Publication date: 2017-05-11
Originaldocument: PMC | Score: 13.317075 | Text size: 66892 | Find: similardocuments
The top 10score-ranking molecules were synthesized by a contract research organization (ChemDiv)and further tested in cell based and in vitro models.
Identification of Antifungal H+-ATPase Inhibitors with Effect on PlasmaMembrane Potential
Lasse Kjellerup; Sandra Gordon; Karen O'HanlonCohrt;William DalbyBrown;Anja ThoeFuglsang;Anne-Marie L.Winther
PMC ID: PMC5487681 | DOI: 10.1128/AAC.00032-17 |ISSN: 0066-4804 | Journal: Antimicrobial Agents and Chemotherapy, 61(1)
Originaldocument: PMC | Score: 13.76273 | Text size: 53127 | Find: similardocuments
Key Organics(13,681 compounds; Cornwall, UK), ChemBridge (63,042 compounds; San Diego,CA), ChemDiv Inc. (34,000 compounds; San Diego, CA), InterBioScreen(24,072 compounds; Chernogolovka, Russia), Specs
Comparative analyses of structural features and scaffold diversity forpurchasable compound libraries
Jun Shang; Huiyong Sun; Hui Liu; Fu Chen; Sheng Tian; Peichen Pan; Dan Li; Dexin Kong; Tingjun Hou
PMC ID: PMC5400773 | DOI: 10.1186/s13321-017-0212-4 |Journal: Journal of Cheminformatics, 9(1) | Publisher: Springer International Publishing | Publication date: 2017-04-21
Originaldocument: PMC | Score: 19.467783 | Text size: 54464 | Find: similardocuments
compoundlibraries deposited in ZINC15 were chosen in the analysis, and they are Mcule,Enamine, ChemDiv, VitasM, UORSY, ChemBridge, LifeChemicals,ZelinskyInstitute, Specs, ChemicalBlock and Maybridge. ... 4,922,295 4,876,889Large, individual service Enamine 1,959,026 1,958,807 Lead-like, diverse ChemDiv1,741,8071,741,603 Selected VitasM 1,460,248 1,460,009 Novel compounds UORSY 1,301,0921,293,353 ... 105,467 964 125,082 514,422 41,024 493,990 1255 85 543 345025,788 107,898 ChemDiv 103,562 440 129,997 512,142 40,933369,011 2021 69 784 3493 21,875 93,439 ChemicalBlock 96,236 1204 ... chains(3543) is at the average level, which is still higher than those of ChemBridge(3450) and ChemDiv (3493). However, Chembridge and ChemDiv bearthe top two numbers of chains (>510,000).
Cytotoxicity of Zardaverine in Embryonal Rhabdomyosarcoma from a CostelloSyndrome Patient
Donna M.Cartledge;Katherine M.Robbins;Katherine M.Drake;Rachel Sternberg; Deborah L.Stabley;Karen W. Gripp; E. Anders Kolb; Katia Sol-Church; Andrew D. Napper
PMC ID: PMC5376947 | DOI: 10.3389/fonc.2017.00042 |Journal: Frontiers in Oncology, 7(1) | Publisher: Frontiers Media S.A. | Publicationdate: 2017-04-03
Originaldocument: PMC | Score: 13.42576 | Text size: 69015 | Find: similardocuments
followingzardaverine analogs were supplied through Ryan Scientific (Mount Pleasant, SC,USA): ChemDivD216-0257, D216-0505, and D216-0543; Life ChemicalsF1967-0306 and F1967-0458; Specs
AnzhalikaSidarovich;Cindy L Will; Maria M Anokhina; Javier Ceballos; Sonja Sievers; Dmitry EAgafonov;Timur Samatov; Penghui Bao; Berthold Kastner; Henning Urlaub; Herbert Waldmann; ReinhardLührmann; Timothy W Nilsen
PMC ID: PMC5354520 | DOI: 10.7554/eLife.23533 |Journal: eLife, 6(1) | Publisher: eLifeSciences Publications, Ltd | Publicationdate: 2017-03-16
Originaldocument: PMC | Score: 16.041449 | Text size: 117036 | Find: similardocuments
pyrimidine-2,4,6(1H,3H,5H)-trione (synthesized in-house or purchased from ChemDiv,cat. no. 3679-1153) dissolved in DMSO, and were incubated at 30°C for theindicated times. ... (2277–0005), 164502 (0327–0135), 344340 (0327–0183) and344341 (0327–0199) were purchased from ChemDiv (catalog numberin parentheses) and their purity was determined by HPLC-MS prior to use.
AnzhalikaSidarovich;Cindy L Will; Maria M Anokhina; Javier Ceballos; Sonja Sievers; Dmitry EAgafonov;Timur Samatov; Penghui Bao; Berthold Kastner; Henning Urlaub; Herbert Waldmann; ReinhardLührmann; Timothy W Nilsen
PMC ID: PMC5354520 | DOI: 10.7554/eLife.23533 |Journal: eLife, 6(1) | Publisher: eLifeSciences Publications, Ltd | Publicationdate: 2017-03-16
Originaldocument: PMC | Score: 15.2631445 | Text size: 4095 | Find: similardocuments
splicing andalso provide the catalogue numbers for all of the compounds that we purchasedfrom ChemDiv.
Waseem Al-Jameel; Xiaojun Gou; Shiva S.Forootan;Majed Saad AlFayi;Philip S.Rudland;Farzad S.Forootan;Jiacheng Zhang; Philip A.Cornford;Syed A. Hussain; Youqiang Ke
PMC ID: PMC5458187 | DOI: 10.18632/oncotarget.16055 |Journal: Oncotarget, 8(1) pp. 31041-31056 |Publisher: Impact Journals LLC |Publication date: 2017-03-09
Originaldocument: PMC | Score: 13.996932 | Text size: 56836 | Find: similardocuments
SBFI19 (cat#5511-0235), SBFI27 (cat# 8009-7646) and SBFI31 (cat# C075-0064) were purchasedfromChemDiv, dissolved in DMSO, and stored at –20°C.
Melissa S. Love; Federico C.Beasley;Rajiv S. Jumani; Timothy M.Wright;Arnab K.Chatterjee;Christopher D.Huston;Peter G. Schultz; Case W. McNamara; Timothy G. Geary
PMC ID: PMC5310922 | DOI: 10.1371/journal.pntd.0005373 |ISSN: 1935-2727 | Journal: PLoS Neglected Tropical Diseases, 11(1)
Originaldocument: PMC | Score: 13.648543 | Text size: 64131 | Find: similardocuments
powders(> 95% purity) from Selleck Chemicals, Calbiochem, Ambinter, Enzo LifeSciences, NCI, ChemDiv, or Life Chemicals.
Liangxian Cao; Marla Weetall; Jenelle Bombard; Hongyan Qi; Tamil Arasu; William Lennox; Jean Hedrick; Josephine Sheedy; Nicole Risher; Peter C. Brooks; PanayiotaTrifillis;ChristopherTrotta;Young-Choon Moon; John Babiak; Neil G. Almstead; Joseph M.Colacino;Thomas W. Davis; Stuart W. Peltz; Thomas Preiss
PMC ID: PMC5161367 | DOI: 10.1371/journal.pone.0168366 |Journal: PLoS ONE, 11(1) | Publisher: PublicLibrary of Science | Publicationdate: 2016-12-16
Originaldocument: PMC | Score: 13.648543 | Text size: 62792 | Find: similardocuments
were chosenand commercially purchased from several vendors, including about 80,000compounds fromChemDiv (San Diego, CA), 30,000 from Coelacanthchemical (New Jersey), 37,000 from ChemBridge corporation
Jude T. Chenge; Le Van Duyet; Shalini Swami; Kirsty J. McLean; Madeline E.Kavanagh;Anthony G. Coyne; Stephen E. J.Rigby;Myles R.Cheesman;Hazel M. Girvan; Colin W. Levy; Bernd Rupp; Jens P. vonKries;Chris Abell; David Leys; Andrew W. Munro
PMC ID: PMC5270475 | DOI: 10.1074/jbc.M116.748822 |ISSN: 0021-9258 | Journal: The Journal of Biological Chemistry, 292(1) pp.1310-1329|Publisher: American Society for Biochemistry and Molecular Biology | Publication date: 2016-12-08 | Print publication date: 2017-01-27
Originaldocument: PMC | Score: 15.81019 | Text size: 103371 | Find: similardocuments
wereidentified as “hits,” and the top ranking compounds were purchased, whereavailable, from ChemDiv (San Diego, CA) or Vitas M (Apeldoorn,The Netherlands). ... Medicinal Chemistry, Leibniz Institute of MolecularPharmacology (Berlin, Germany) or sourced from ChemDiv orVitas M. Bacterial growth medium (2xYT) was from Melford Laboratories (Ipswich,Suffolk, UK).
Yunyu Chen; Jing Zhang; Dongsheng Li; Jiandong Jiang; Yanchang Wang; Shuyi Si
PMC ID: PMC5352051 | DOI: 10.18632/oncotarget.13603 |Journal: Oncotarget, 8(1) pp. 1234-1246 |Publisher: Impact Journals LLC |Publication date: 2016-11-25
Originaldocument: PMC | Score: 16.279572 | Text size: 52079 | Find: similardocuments
From arandom compound library purchased from ChemDiv (20,000compounds), T521 was identified as a potent Plk1 PBD inhibitor with an IC50 of1.22±0. ... potent Plk1 PBD inhibitor from the diverse chemical libraries of20,000 small-molecule compounds (ChemDiv). Because a large amount ofT521 was needed for its characterization, we designed chemical
Ben Hu; Zheng-Kun Kuang; Shi-Yu Feng; Dong Wang; Song-Bing He; De-Xin Kong; James W. Gauld
PMC ID: PMC6273508 | DOI: 10.3390/molecules21111554 |Journal: Molecules, 21(1) | Publisher: MDPI | Publication date: 2016-11-17
Originaldocument: PMC | Score: 14.426556 | Text size: 67349 | Find: similardocuments
virtualscreening contained more than 300,000 drug-like or lead-like compounds derivedfrom Specs,ChemDiv, and Enamine.
Phenylphthalazines as small-molecule inhibitors of urea transporter UT-Band their binding model
Jian-hua Ran; Min Li; Weng-Ieong Tou; Tian-luo Lei; Hong Zhou; Calvin Yu-ChianChen;Bao-xue Yang
PMC ID: PMC4933761 | DOI: 10.1038/aps.2016.4 |ISSN: 1671-4083 | Journal: Acta Pharmacologica Sinica, 37(1) pp. 973-983 |Publisher:NaturePublishing Group | Publicationdate: 2016-05-30 | Print publication date: 2016-07
Originaldocument: PMC | Score: 16.524874 | Text size: 43068 | Find: similardocuments
primaryscreening was performed using a collection of 10 000 diverse, drug-likecompounds from ChemDiv, Inc (San Diego, CA, USA), and 96-wellplates containing a single compound per well (2. ... Structure-activityrelationship Approximately 160 commercially available analogs (ChemDiv Inc,San Diego, CA, USA) of active compounds identified in the primary screeningwere tested against
Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effecton ANO2
Yohan Seo; Ho K. Lee; Jinhong Park; Dong-kyu Jeon; Sungwoo Jo; Minjae Jo; Wan Namkung; Alexander A.Mongin
PMC ID: PMC4878759 | DOI: 10.1371/journal.pone.0155771 |Journal: PLoS ONE, 11(1) | Publisher: PublicLibrary of Science | Publicationdate: 2016-05-24
Originaldocument: PMC | Score: 16.360525 | Text size: 47331 | Find: similardocuments
Ani9 and itsanalogs were purchased from ChemDiv (San Diego, CA).Recombinant Human IL-4 was purchased from R&D systems (Minneapolis, MN).The compound collections used for screening included 54,400 drug-like moleculeswere purchased from ChemDiv.
Pharmit: interactive exploration of chemical space
Jocelyn Sunseri; David Ryan Koes
PMC ID: PMC4987880 | DOI: 10.1093/nar/gkw287 |ISSN: 0305-1048 | Journal: Nucleic Acids Research, 44(1) pp. W442-W448 |Publisher:OxfordUniversity Press | Publicationdate: 2016-04-19 | Print publication date: 2016-07-08
Originaldocument: PMC | Score: 14.951023 | Text size: 28906 | Find: similardocuments
Pharmit haspre-built libraries generated from CHEMBL21 (10), with >1.4 millioncompounds; ChemDiv(www.chemdiv.com), with >1.4 millioncompounds; MolPort (www.molport.com), with >6.
Structure–Activity Relationship for the 4(3H)-QuinazolinoneAntibacterials
Renee Bouley; Derong Ding; Zhihong Peng; Maria Bastian; Elena Lastochkin; Wei Song; Mark A. Suckow; Valerie A.Schroeder;William R.Wolter;ShahriarMobashery;Mayland Chang
PMC ID: PMC4885108 | DOI: 10.1021/acs.jmedchem.6b00372 |ISSN: 0022-2623 | Journal: Journal of Medicinal Chemistry, 59(1) pp. 5011-5021 |Publisher: American Chemical Society | Publicationdate: 2016-04-18 | Print publication date: 2016-05-26
Originaldocument: PMC | Score: 13.648543 | Text size: 65531 | Find: similardocuments
72quinazolinone derivatives (Scheme 1), and an additional 5 compounds werepurchased from ChemDiv.
MélaineA. Kuenemann; Céline M.Labbé; Adrien H. Cerdan; Olivier Sperandio
PMC ID: PMC4817116 | DOI: 10.1038/srep23815 |Journal: Scientific Reports, 6(1) | Publisher: NaturePublishing Group | Publication date:2016-04-01
Originaldocument: PMC | Score: 13.996932 | Text size: 70381 | Find: similar documents
fromcommercial databases BDM 39,186 Compounds from commercial databases(Asinex, ChemDiv and Enamine) Table 2 All of the names of the2D descriptors and their description.
Pamela A.Magistrado;Victoria C.Corey;Amanda K. Lukens; Greg LaMonte; Erika Sasaki; Stephan Meister; Melanie Wree; ElizabethWinzeler;Dyann F. Wirth
PMC ID: PMC5109296 | DOI: 10.1021/acsinfecdis.6b00025 |Journal: ACS Infectious Diseases, 2(1) pp. 816-826 | Publisher: AmericanChemical Society | Publicationdate: 2016-03-28 | Print publication date: 2016-11-11
Originaldocument: PMC | Score: 14.2392435 | Text size: 56141 | Find: similardocuments
10(C776-3585), 11 (C776-3587), 12 (C776-3670), 13 (C776-3575), and 14 (C776-3628)were from ChemDiv, USA; quinine, atovaquone, and mefloquine were fromSigma-Aldrich, USA.
Structure-Based Drug Design of Small Molecule Peptide DeformylaseInhibitors to Treat Cancer
Jian Gao; Tao Wang; Shengzhi Qiu; Yasheng Zhu; Li Liang; Youguang Zheng; Derek J. McPhee
PMC ID: PMC6273975 | DOI: 10.3390/molecules21040396 |Journal: Molecules, 21(1) | Publisher: MDPI | Publication date: 2016-03-23
Originaldocument: PMC | Score: 16.863674 | Text size: 32414 | Find: similardocuments
the crystalstructure (3G5K) was utilized to screen the HsPDF inhibitors from theTopscience ChemDivdatabase (commercially available). ... The smallmolecule database was the ChemDiv database (commerciallyavailable) from Topscience Co.
Global Survey of Cell Death Mechanisms Reveals Metabolic Regulation ofFerroptosis
Kenichi Shimada; Rachid Skouta; Anna Kaplan; Wan Seok Yang; Miki Hayano; Scott J. Dixon; Lewis M. Brown; Carlos A.Valenzuela;Adam J. Wolpaw;Brent R.Stockwell
PMC ID: PMC4920070 | DOI: 10.1038/nchembio.2079 |ISSN: 1552-4450 | Journal: Nature chemical biology, 12(1) pp. 497-503 |Publicationdate: 2016-03-19 | Print publication date: 2016-07
Originaldocument: PMC | Score: 13.648543 | Text size: 66174 | Find: similar documents
compounds,as well as structural analogs of CIL41/70, were purchased from Asinex,ChemBridge, ChemDiv, Enamine, InterBioScreen, MayBridge, TimTec,Vitas M Labs, and Zelinsky.
Nuclear envelope expansion is crucial for proper chromosomal segregationduring a closed mitosis
Ai Takemoto; Shigehiro A.Kawashima;Juan-Juan Li; Linda Jeffery; Kenzo Yamatsugu; Olivier Elemento; Paul Nurse
PMC ID: PMC4813296 | DOI: 10.1242/jcs.181560 |ISSN: 0021-9533 | Journal: Journal of Cell Science, 129(1) pp. 1250-1259 |Publisher: The Company of Biologists Ltd | Publicationdate: 2016-03-15 | Print publication date: 2016-03-15
Originaldocument: PMC | Score: 16.524874 | Text size: 52513 | Find: similardocuments
In the end,the collection of 30 plates contained 2112 ChemDiv (San Diego,CA) compounds, 352 AMRI (Albany, NY) compounds, 5280 Enamine (Kiev, Ukraine)compounds, ... Registry Number: 53296-08-5), and Cutin-2 (CAS Registry Number:957489-42-8) were purchased from ChemDiv (San Diego, CA).
Small molecule inhibitors of the Dishevelled
Hyun
PMC ID: PMC4818757 | DOI: 10.15252/emmm.201505714 |ISSN: 1757-4676 | Journal: EMBO Molecular Medicine, 8(1) pp. 375-387 |Publisher: John Wileyand Sons Inc. | Publicationdate: 2016-03-03 | Print publication date: 2016-04
Originaldocument: PMC | Score: 13.996932 | Text size: 52543 | Find: similardocuments
of KoreaResearch Institute of Chemical Technology (Daejeon, Korea) or were purchasedfrom ChemDiv Inc.(San Diego, CA).
Alex C. D.Salyer;Giuseppe Caruso; Karishma K.Khetani;Lauren M. Fox; Subbalakshmi S.Malladi;Sunil A. David; SuryaprakashSambhara
PMC ID: PMC4769227 | DOI: 10.1371/journal.pone.0149848 |Journal: PLoS ONE, 11(1) | Publisher: PublicLibrary of Science | Publicationdate: 2016-02-26
Originaldocument: PMC | Score: 14.301138 | Text size: 49042 | Find: similardocuments
HighThroughput Screening laboratory which include Life Chemicals (15,040),ChemBridge (43,736), ChemDiv(56,232), Selleck Bioactives (1649),TimTec (5000), and FDA Repurposed Library (2,286) were used.
R. Balajee; V.Srinivasadesikan; M. Sakthivadivel; P. Gunasekaran
PMC ID: PMC4785246 | DOI: 10.1155/2016/7264080 |ISSN: 2090-2247 | Journal: Biochemistry Research International, 2016(1) | Publisher:Hindawi Publishing Corporation | Publication date: 2016-02-25 | Print publication date: 2016
Originaldocument: PMC | Score: 18.879087 | Text size: 43739 | Find: similardocuments
Ligand5PubChem −38.16 1.29 6 Ligand6 PubChem −44.67 33.89 7 Ligand7PubChem −45.83 0.1 8 Ligand8ChemDiv −48.40 15.6 9Ligand9 ChemDiv −44.21 86.7 10 Ligand10 ChemDiv −31.3432.2 11 Ligand11ChemDiv −41.67 12.5 12 Ligand12 ChemDiv −39.143.9 13 Ligand13 ChemDiv −39.09 26.4 14 Ligand14ChemDiv −51.3175.3 15 Ligand15 PubChem −42.52 0.12 16 Ligand16 PubChem −31.57 4.717 Ligand17 PubChem −35.
Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
Laetitia J.Martin;Manfred Koegl; Gerd Bader; Xiao-LingCockcroft;Oleg Fedorov; Dennis Fiegen; ThomasGerstberger;Marco H. Hofmann; Anja F. Hohmann; Dirk Kessler; Stefan Knapp; Petr Knesl; Stefan Kornigg; SusanneMüller;Herbert Nar; Catherine Rogers; Klaus Rumpel; Otmar Schaaf;Steffen Steurer; Cynthia Tallant; Christopher R.Vakoc;Markus Zeeb; Andreas Zoephel; Mark Pearson; Guido Boehmelt; Darryl McConnell
PMC ID: PMC4885110 | DOI: 10.1021/acs.jmedchem.5b01865 |ISSN: 0022-2623 | Journal: Journal of Medicinal Chemistry, 59(1) pp. 4462-4475 |Publisher: American Chemical Society | Publicationdate: 2016-02-25 | Print publication date: 2016-05-26
Originaldocument: PMC | Score: 13.76273 | Text size: 57065 | Find: similardocuments
Compound 3is commercially available from, e.g., ChemDiv.
Targeting BRCA1- and BRCA2-deficient cells with RAD52 small moleculeinhibitors
Fei Huang; Nadish Goyal; KatherineSullivan;KritikaHanamshet;Mikir Patel; Olga M. Mazina; Charles X. Wang; W. Frank An; James Spoonamore;Shailesh Metkar; Kyle A. Emmitte; Simon Cocklin; Tomasz Skorski; Alexander V.Mazin
PMC ID: PMC4872086 | DOI: 10.1093/nar/gkw087 |ISSN: 0305-1048 | Journal: Nucleic Acids Research, 44(1) pp. 4189-4199 |Publisher:OxfordUniversity Press | Publicationdate: 2016-02-11 | Print publication date: 2016-05-19
Originaldocument: PMC | Score: 13.878843 | Text size: 52951 | Find: similardocuments
Thecompounds for confirmation analysis were purchased from Asinex Ltd., ChemBridgeCo., ChemDiv Inc, Enamine, FCH Group, Frontier Scientific ServicesInc., InterBioScreen Ltd., Life Chemicals Inc.
DDRI-9: a novel DNA damage response inhibitor that blocks mitoticprogression
Dong Wha Jun; Mihwa Hwang; Yun-Hee Kim; Kyung-Tae Kim; Sunshin Kim; Chang-Hun Lee
PMC ID: PMC4951243 | DOI: 10.18632/oncotarget.7135 |Journal: Oncotarget, 7(1) pp. 17699-17710 |Publisher: Impact Journals LLC |Publication date: 2016-02-02
Originaldocument: PMC | Score: 14.2392435 | Text size: 39331 | Find: similardocuments
(C13H10FN5O4)was provided by the Korea Chemical Bank (Daejeon, Korea) or purchased fromeitherChemDiv (La Jolla, CA, USA) or Hanchem (Daejeon, Korea).
Bryan Mitton; Katie Hsu; Ritika Dutta; Bruce C. Tiu; Nick Cox; Kevin G. McLure; Hee-Don Chae; Mark Smith; Elizabeth A.Eklund;David E.Solow-Cordero; Kathleen M.Sakamoto
PMC ID: PMC4890994 | DOI: 10.18632/oncotarget.7085 |Journal: Oncotarget, 7(1) pp. 8653-8662 |Publisher: Impact Journals LLC |Publication date: 2016-01-30
Original document: PMC | Score: 16.777678 | Text size: 29614 | Find: similardocuments
Thiscollection was assembled from several commercial vendors, including ChemDiv,Specs, and Chembridge, and possesses drug-like qualities [7]. ... Thesecompounds are drug-like and were assembled from various commercial sourcesincluding, ChemDiv (60 K), Specs (30 K), and Chembridge (23.5K).
Onur Cil; Puay-Wah Phuan; Sujin Lee; Joseph Tan; Peter M. Haggie; Marc H. Levin; Liang Sun; Jay R.Thiagarajah;Tonghui Ma; Alan S. Verkman
PMC ID: PMC4844355 | DOI: 10.1016/j.jcmgh.2015.12.010 |Journal: Cellular and Molecular Gastroenterology andHepatology, 2(1) pp. 317-327| Publisher: Elsevier | Publication date: 2016-01-09
Originaldocument: PMC | Score: 16.360525 | Text size: 45259 | Find: similardocuments
wasperformed using a diverse collection of 120,000 drug-like synthetic compoundsobtained from ChemDiv, Inc (San Diego, CA) and Asinex(Winston-Salem, NC). For structure-activity analysis, 600 commerciallyavailable analogs (ChemDiv, Inc) of active compounds identified in theprimary screen were tested.
Tina M. Sali; Kara M. Pryke; Jinu Abraham; Andrew Liu; Iris Archer; Rebecca Broeckel; Julia A.Staverosky;Jessica L. Smith; AhmedAl-Shammari;Lisi Amsler; Kayla Sheridan; Aaron Nilsen; Daniel N.Streblow;Victor R. DeFilippis; Sara Cherry
PMC ID: PMC4672893 | DOI: 10.1371/journal.ppat.1005324 |ISSN: 1553-7366 | Journal: PLoS Pathogens, 11(1) | Publisher: PublicLibrary of Science | Publicationdate: 2015-12-08
Originaldocument: PMC | Score: 12.899377 | Text size: 100799 | Find: similardocuments
Stocks ofG10 were purchased from ChemDiv.
Jungseog Kang; Chien-Hsiang Hsu; Qi Wu; Shanshan Liu; Adam D. Coster; Bruce A. Posner; Steven J.Altschuler;Lani F. Wu
PMC ID: PMC4844861 | DOI: 10.1038/nbt.3419 |ISSN: 1087-0156 | Journal: Nature biotechnology, 34(1) pp. 70-77 |Publicationdate: 2015-11-10 | Print publication date: 2016-01
Originaldocument: PMC | Score: 13.996932 | Text size: 71285 | Find: similardocuments
approximatingthe chemical diversity of the 230K institutional library that was purchasedfrom ChemDiv, ChemBridge, Comgenix, and TimTek).
Discovery of Small Molecules that Inhibit the Disordered Protein, p27Kip1
Luigi I. Iconaru; David Ban; KavithaBharatham;ArvindRamanathan;Weixing Zhang; Anang A. Shelat; Jian Zuo; Richard W.Kriwacki
PMC ID: PMC4623604 | DOI: 10.1038/srep15686 |Journal: Scientific Reports, 5(1) | Publisher: NaturePublishing Group | Publicationdate:2015-10-28
Originaldocument: PMC | Score: 13.996932 | Text size: 68110 | Find: similardocuments
for Group 1and 2 molecules were used to query a database of 10,455 fragment-like moleculesfrom ChemDiv(www.chemdiv.com) using the FIeldScreen module inForge.
Anthony A.Emanuele;George A. Garcia; Nicholas JMantis
PMC ID: PMC4564171 | DOI: 10.1371/journal.pone.0137410 |Journal: PLoS ONE, 10(1) | Publisher: PublicLibrary of Science | Publicationdate: 2015-09-09
Originaldocument: PMC | Score: 14.117049 | Text size: 52411 | Find: similardocuments
(Moscow,Russia), while compounds 144092, 144143, 153578, and 24904 were purchasedfrom ChemDiv (San Diego, CA). Analogs of 19615 were purchasedthrough Aldrich Market Select (St. Louis, MO).
Zhengjian Zhang; Zarko Boskovic; Mahmud M Hussain; Wenxin Hu; Carla Inouye; Han-Je Kim; A KatherineAbole;Mary K Doud; Timothy A Lewis;Angela N Koehler; Stuart LSchreiber;Robert Tjian; Danny Reinberg
PMC ID: PMC4582147 | DOI: 10.7554/eLife.07777 |ISSN: 2050-084X | Journal: eLife, 4(1) | Publisher: eLifeSciences Publications, Ltd |Publication date: 2015-08-28
Originaldocument: PMC | Score: 19.331345 | Text size: 103808 | Find: similardocuments
Weidentified one compound (1, ChemDiv 7241-4207) thatreproducibly and selectively bound to both Drosophila and human TFIID (Figure... Yellow arrows denote the lead compound (1, ChemDiv 7241-4207).... We found that the commercially supplied compound 1 (ChemDiv 7241-4207)inhibited both Drosophila and human TFIID-directed transcription, but nottranscription ... transcription, but not TBP-directed transcription, by theoriginally purchased lead compound (1, ChemDiv 7241-4207). ...More specifically, ‘ChemDiv’ stands forChemDiv Inc. (SanDiego, CA); ‘Otava’ stands for Otava Ltd (Vaughan, Canada); ‘Princeton’ standsfor Princeton
Myosin 1b functions as an effector of EphB signaling to control cellrepulsion
Marie-ThérèseProspéri; PriscillaLépine; Florent Dingli; PerrinePaul-Gilloteaux; RenéMartin;Damarys Loew; Hans-JoachimKnölker; Evelyne Coudrier
PMC ID: PMC4508888 | DOI: 10.1083/jcb.201501018 |ISSN: 0021-9525 | Journal: The Journal of Cell Biology, 210(1) pp. 347-361 |Publisher:TheRockefeller University Press | Publicationdate: 2015-07-20 | Print publication date: 2015-07-20
Originaldocument: PMC | Score: 13.648543 | Text size: 68898 | Find: similardocuments
Drugtreatments 100 μm CK666 (ChemDiv,Inc.) in 0.1% DMSO, 50 μm blebbistatin (Sigma-Aldrich) in 0.3% DMSO, and 1 μm PCIP (giftfrom H.-J.
Luca Laraia; Grahame McKenzie; David R. Spring; Ashok R.Venkitaraman; David J. Huggins
PMC ID: PMC4518475 | DOI: 10.1016/j.chembiol.2015.04.019 |ISSN: 1074-5521 | Journal: Chemistry & Biology, 22(1) pp. 689-703 |Publisher: Elsevier | Publication date: 2015-06-18 | Print publication date: 2015-06-18
Originaldocument: PMC | Score: 16.44229 | Text size: 93702 | Find: similardocuments
ChemDiv, Asinex,Comminex, Life Chemicals, Otava Chemicals, and NQuix all have librariestargeted at PPIs, ... NA NA http://nquix.com/screening-libraries ChemDiv 125,000peptidomimetics http://www.chemdiv.
Heather MDickson;Amanda Wilbur; Ashley A Reinke; Mathew A Young; Anne B Vojtek
PMC ID: PMC4467669 | DOI: 10.1186/s12868-015-0171-5 |Journal: BMC Neuroscience, 16(1) | Publisher: BioMed Central | Publicationdate: 2015-06-16
Originaldocument: PMC | Score: 17.397476 | Text size: 49546 | Find: similardocuments
The assaywas then optimized for high-throughput screening in 384-well plates. 20,000compounds (ChemDiv) were screened in the Center for Chemical Genomics atthe University of Michigan. ... with fresh powder 32 of the 36 hits from theprimary screen were available for purchase from ChemDiv andwere diluted in DMSO and stored at −20°C. ... (10 μM,Calbiochem, San Diego, CA, USA), a ROCK 1/2 inhibitor, or CCG-17444 (25 μM of3347-0032, ChemDiv, San Diego, CA, USA), were added to CGNs inculture media [DMEM (Invitrogen) supplemented with 2%
Identification of β
Kim Y. Fong; Rebecca D.Sandlin;David W. Wright
PMC ID: PMC4486462 | DOI: 10.1016/j.ijpddr.2015.05.003 |Journal: International Journal for Parasitology: Drugs and Drug Resistance, 5(1) pp.84-91 |Publisher: Elsevier | Publicationdate: 2015-06-06
Originaldocument: PMC | Score: 14.2392435 | Text size: 42195 | Find: similardocuments
Malaria Box,the additional testing was conducted using compounds purchased from ChemBridgeandChemDiv.
New Small Molecules Targeting Apoptosis and Cell Viability inOsteosarcoma
Doris Maugg; Ina Rothenaigner; Kenji Schorpp; Harish KumarPotukuchi;EberhardKorsching;Daniel Baumhoer; Kamyar Hadian; Jan Smida;MichaelaNathrath;DominiqueHeymann
PMC ID: PMC4454490 | DOI: 10.1371/journal.pone.0129058 |Journal: PLoS ONE, 10(1) | Publisher: PublicLibrary of Science | Publicationdate: 2015-06-03
Original document: PMC | Score: 13.76273 | Text size: 56891 | Find: similardocuments
The twocompounds found in the screening were obtained from ChemDiv (SanDiego, CA), and can be re-ordered using the compound IDs for A13 (compound ID:6228–2300) and
Maryati Maryati; BlessingAirhihen;G. SebastiaanWinkler
PMC ID: PMC4613498 | DOI: 10.1042/BJ20150304 |ISSN: 0264-6021 | Journal: Biochemical Journal, 469(1) pp. 169-176 |Publisher: Portland Press Ltd. | Publicationdate: 2015-05-06 | Print publication date: 2015-07-01
Originaldocument: PMC | Score: 16.650314 | Text size: 42713 | Find: similardocuments
ChemDiv),NCC-00001590(N-[6-(isobutylsulfamoyl)-1,3-benzothiazol-2-yl]-2-methyl-benzamide; ChemDiv)and NCC-00039069
Structure–activity exploration of a small-molecule Lipid II inhibitor
Steven Fletcher; Wenbo Yu; Jing Huang; Steven M Kwasny; Jay Chauhan; Timothy JOpperman;Alexander DMacKerell;Erik PH de Leeuw
PMC ID: PMC4422293 | DOI: 10.2147/DDDT.S79504 |Journal: Drug Design, Development and Therapy, 9(1) pp. 2383-2394 | Publisher: Dove MedicalPress |Publicationdate: 2015-04-24
Originaldocument: PMC | Score: 18.75121 | Text size: 38458 | Find: similardocuments
ChemBridgeNo No 8005-4461 C14H16N 198.3 1,2,5-Trimethyl-4-phenylpyridinium ChemDiv NoNo 8005-4525 C14H14N3 224.3 1-Methyl-3-(1-methyl-1H-benzimidazol-2-yl)pyridinium ChemDiv NoNo 8005-4452 C14H17N2 213.3 1,2,5-Trimethyl-4-(phenylamino)pyridinium ChemDiv NoNo 0865-0038 C18H16N3 274.31,3-Dimethyl-2-(quinolin-2-yl)-1H-3,1-benzimidazol-3-lum ChemDiv NoNo 0865-0043 C14H14N 196.3 1-Methyl-2-[(E)-2-phenylethenyl]pyridinium ChemDiv NoNo 8009-7229 C23H22ClN3O 391.91-(4-Chlorophenyl)-3-methyl-4-[2-(1,3,3-trimethylindolin-2-ylidene)ethylidene]-1,2-diazolin-5-one ChemDiv NoNo Z56594936 C19H18BrNO 356.
Selective activators of protein phosphatase 5 target the auto-inhibitorymechanism
VeronikaHaslbeck;Adrian Drazic; Julia M. Eckl; Ferdinand Alte; Martin Helmuth; GrzegorzPopowicz;Werner Schmidt; Frank Braun; Matthias Weiwad; Gunter Fischer; Gerd Gemmecker; Michael Sattler; Frank Striggow; Michael Groll; Klaus Richter
PMC ID: PMC4721540 | DOI: 10.1042/BSR20150042 |ISSN: 0144-8463 | Journal: Bioscience Reports, 35(1) | Publisher: PortlandPress Ltd. |Publication date: 2015-04-20
Originaldocument: PMC | Score: 17.614815 | Text size: 49370 | Find: similardocuments
NewChemistry and Discovery Chemistry Collection consisting of 10000 compounds wasobtained fromChemDiv. Substances PP5 small-molecule activator (P5SA)-1,P5SA-2, P5SA-3, P5SA-4 and P5SA-5 were purchased from ChemDiv. ...compound library consisting of 10000 compounds (New Chemistry and DiscoveryChemistry Collection, ChemDiv) was screened using a chromometricphosphatase assay with para-nitrophenyl phosphate (pNPP) as
Diana Ortiz; W. Armand Guiguemde; Alex Johnson; Carolyn Elya; Johanna Anderson; Julie Clark; Michele Connelly; Lei Yang; Jaeki Min; Yuko Sato; R. Kiplin Guy; Scott M.Landfear;Stuart AlexanderRalph
PMC ID: PMC4404333 | DOI: 10.1371/journal.pone.0123598 |Journal: PLoS ONE, 10(1) | Publisher: PublicLibrary of Science | Publicationdate: 2015-04-20
Originaldocument: PMC | Score: 13.996932 | Text size: 51793 | Find: similardocuments
Compound 1and 10–15 were purchases from ChemDiv (San Diego, CA).
Douglas R.Houston;Li-Hsuan Yen; Simon Pettit; Malcolm D.Walkinshaw;ManuelaHelmer-Citterich
PMC ID: PMC4401541 | DOI: 10.1371/journal.pone.0121424 |Journal: PLoS ONE, 10(1) | Publisher: PublicLibrary of Science | Publicationdate: 2015-04-17
Originaldocument: PMC | Score: 14.5541935 | Text size: 46122 | Find: similardocuments
in SDFformat of ChemBridge, Asinex, Maybridge, Enamine, LifeChemicals, Specs,InterBioScreen, ChemDivand KeyOrganics were merged.
Discovery of Novel New Delhi Metallo-β-Lactamases-1 Inhibitors by Multistep Virtual Screening
Xuequan Wang; Meiling Lu; Yang Shi; Yu Ou; Xiaodong Cheng; Horacio Bach
PMC ID: PMC4348537 | DOI: 10.1371/journal.pone.0118290 |Journal: PLoS ONE, 10(1) | Publisher: PublicLibrary of Science | Publicationdate: 2015-03-03
Originaldocument: PMC | Score: 14.363574 | Text size: 44807 | Find: similardocuments
bindingsite, 44 molecules (Table B in S1 File) were ultimately selected and purchasedfrom the ChemDiv (San Diego, CA) for experimental validationusing in vitro assays.
Kriti Singh; Ravi ShashiNayana Munuganti; Eric Leblanc; Yu Lun Lin; Euphemia Leung; Nada Lallous; Miriam Butler; Artem Cherkasov; Paul S Rennie
PMC ID: PMC4360945 | DOI: 10.1186/s13058-015-0529-8 |ISSN: 1465-5411 | Journal: Breast Cancer Research : BCR, 17(1) | Publisher:BioMed Central | Publication date: 2015-02-25 | Print publication date: 2015
Originaldocument: PMC | Score: 13.42576 | Text size: 75135 | Find: similardocuments
(San Diego,CA, USA; compounds VPC-16007, VPC-16003, VPC-16004, VPC-16222 andVPC-16223), ChemDiv(San Diego, CA, USA; compound VPC-16019), TimTec(Newark, DE, USA; compounds VPC-16041, VPC-16046,
A Serpin Shapes the Extracellular Environment to Prevent Influenza AVirus Maturation
Meike Dittmann; Hans-HeinrichHoffmann;Margaret A. Scull; Rachel H.Gilmore;Kierstin L. Bell; MichaelCiancanelli;Sam J. Wilson; Stefania Crotta; Yingpu Yu; Brenna Flatley; Jing W. Xiao; Jean-LaurentCasanova;Andreas Wack; Paul D. Bieniasz; Charles M. Rice
PMC ID: PMC4328142 | DOI: 10.1016/j.cell.2015.01.040 |ISSN: 0092-8674 | Journal: Cell, 160(1) pp. 631-643 |Publisher: Cell Press |Publication date: 2015-02-12 | Printpublication date: 2015-02-12
Originaldocument: PMC | Score: 13.317075 | Text size: 79183 | Find: similardocuments
Diphyllin (ChemDiv)was used to block IAV entry at 10 μM, and Ribavirin at 500 μM asreplication inhibition control,
Target validation and structure–activity analysis of a series of novelPCNA inhibitors
Kelsey LDillehay;William L Seibel; Daoli Zhao; Shan Lu; Zhongyun Dong
PMC ID: PMC4324689 | DOI: 10.1002/prp2.115 |ISSN: 2052-1707 | Journal: Pharmacology Research & Perspectives, 3(1)
Originaldocument: PMC | Score: 14.301138 | Text size: 40221 | Find: similardocuments
SAR-15 andSAR-16 were purchased from ChemDiv (San Diego, CA).
JulioAlonso-Padilla; Ignacio Cotillo; Jesús L.Presa;Juan Cantizani; ImanolPeña;Ana I. Bardera; Jose J.Martín; Ana Rodriguez; Genevieve Milon
PMC ID: PMC4304841 | DOI: 10.1371/journal.pntd.0003493 |ISSN: 1935-2727 | Journal: PLoS Neglected Tropical Diseases, 9(1)
Originaldocument: PMC | Score: 14.117049 | Text size: 52266 | Find: similardocuments
mesylate(Tocris Bioscience), hydrazide derivative PCH1 (InterBioScreen), LP10 (ChemDiv),loperamide (Enamine), posaconazole (Sheckchem.
Compounds targeting disulfide bond forming enzyme DsbB of Gram-negativebacteria
Cristina Landeta; Jessica L.Blazyk;Feras Hatahet; Brian M. Meehan; Markus Eser; Alissa Myrick; LudmilaBronstain;Shoko Minami; Holly Arnold;Na Ke; Eric J. Rubin; Barbara C. Furie; Bruce Furie; Jon Beckwith; Rachel Dutton; Dana Boyd
PMC ID: PMC4366281 | DOI: 10.1038/nchembio.1752 |ISSN: 1552-4450 | Journal: Nature chemical biology, 11(1) pp. 292-298 |Publicationdate: 2015-01-08 | Print publication date: 2015-04
Originaldocument: PMC | Score: 13.648543 | Text size: 68715 | Find: similar documents
50,374compounds from several commercial small molecule libraries (Asinex 1,ChemBridge 3, ChemDiv 4, Life Chemicals 1, and Enamine 2) andsmall libraries of known bioactive molecules and natural
Novel PDE4 Inhibitors Derived from Chinese Medicine Forsythia
Tiffany A. Coon; Alison C.McKelvey;Nate M.Weathington;Rahel L. Birru; Travis Lear; George D.Leikauf;Bill B. Chen; Min Wu
PMC ID: PMC4280171 | DOI: 10.1371/journal.pone.0115937 |Journal: PLoS ONE, 9(1) | Publisher: PublicLibrary of Science | Publicationdate: 2014-12-30
Original document: PMC | Score: 14.363574 | Text size: 34844 | Find: similardocuments
Forsythinwas from Stanford Chemicals; all other synthetic compounds were purchasedfrom ChemDiv, Inc.and Vitas-M Laboratory, Ltd. All compounds are>98% pure by HPLC.
A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS AutoimmuneInflammatory Disease
Kareem L. Graham; Jian V. Zhang; SusannaLewén; Thomas M. Burke; Ton Dang; Maria Zoudilova; Raymond A. Sobel; Eugene C.Butcher;Brian A. Zabel; Michael Platten
PMC ID: PMC4249827 | DOI: 10.1371/journal.pone.0112925 |Journal: PLoS ONE, 9(1) | Publisher: PublicLibrary of Science | Publicationdate: 2014-12-01
Originaldocument: PMC | Score: 13.42576 | Text size: 68210 | Find: similardocuments
The StanfordHTBC compound library contains ∼130,000 diverse compounds from ChemDiv (60,000), SPECS(30,000), Chembridge (23,500), ChemRX (10,000), Microsource Sepctrum,(2,320),Enzo
Kendra K. Harris; Allison Fay; Han-Guang Yan; Pratima Kunwar; Nicholas D.Socci;NarenderPottabathini; Ramakrishna R.Juventhala;Hakim Djaballah; Michael S.Glickman
PMC ID: PMC4245167 | DOI: 10.1021/cb500573z |ISSN: 1554-8929 | Journal: ACS Chemical Biology, 9(1) pp. 2572-2583 |Publisher:AmericanChemical Society | Publicationdate: 2014-09-15 | Print publication date: 2014-11-21
Originaldocument: PMC | Score: 14.301138 | Text size: 45216 | Find: similardocuments
obtainedfrom ChemBridge Research Laboratories, Biofocus, AnalytiCon Discovery, SPECS,NCI, ChemDiv, and Magellan Bioscience.
Rebecca D.Sandlin;Kim Y. Fong; Kathryn J. Wicht; Holly M. Carrell; Timothy J. Egan; David W. Wright
PMC ID: PMC4266794 | DOI: 10.1016/j.ijpddr.2014.08.002 |Journal: International Journal for Parasitology: Drugs and Drug Resistance, 4(1) pp.316-325 | Publisher: Elsevier | Publicationdate: 2014-09-11
Originaldocument: PMC | Score: 16.524874 | Text size: 44692 | Find: similardocuments
Thescreening library consisted of compounds originating from ChemBridge and ChemDiv.... in the Vanderbilt University High-Throughput Screening Facility originatedfrom ChemBridge and ChemDiv.
A broad HIV-1 inhibitor blocks envelope glycoprotein transitions criticalfor entry
Alon Herschhorn; Christopher Gu; Nicole Espy; Jonathan Richard; AndrésFinzi;Joseph G.Sodroski
PMC ID: PMC4231716 | DOI: 10.1038/nchembio.1623 |ISSN: 1552-4450 | Journal: Nature chemical biology, 10(1) pp. 845-852 |Publicationdate: 2014-08-31 | Print publication date: 2014-10
Originaldocument: PMC | Score: 13.76273 | Text size: 63676 | Find: similardocuments
were fromChembridge, San Diego, CA; compounds 613 (24), 616 (27), 620 (31) and 621 (32)were fromChemDiv, San Diego, CA.
Screening-based discovery of Aspergillus fumigatus plant-type chitinaseinhibitors
Deborah E.A.Lockhart;AlexanderSchuettelkopf; David E. Blair; Daan M.F. vanAalten
PMC ID: PMC4158421 | DOI: 10.1016/j.febslet.2014.07.015 |ISSN: 0014-5793 | Journal: Febs Letters, 588(1) pp. 3282-3290 |Publisher:ElsevierScience B.V | Publicationdate: 2014-08-25 | Print publication date: 2014-08-25
Originaldocument: PMC | Score: 14.426556 | Text size: 40879 | Find: similardocuments
Compounds 1,2, 6 and 7 (ChemBridge Corporation, San Diego, CA, USA); compounds 3, 4 and 8 (ChemDiv,San Diego, CA, USA); compounds 9 and 11 (Asinex Europe, Rijswijk, NED);compound 5 (Maybridge,
Rajini Mudhasani; Krishna P. Kota; Cary Retterer; Julie P. Tran; Chris A.Whitehouse;Sina Bavari; Anton Simeonov
PMC ID: PMC4140764 | DOI: 10.1371/journal.pntd.0003095 |ISSN: 1935-2727 | Journal: PLoS Neglected Tropical Diseases, 8(1)
Originaldocument: PMC | Score: 18.981396 | Text size: 77242 | Find: similardocuments
CompoundLibrary and Reference Reagents ChemDiv was the source of theSerine/Cysteine Protease (SCP) inhibitor library used in this study. ChemDiv builtthe library using a variety of computational programs to qualify a smallmolecule as a ... For subsequent mechanism of action studies, compounds werereordered (ChemDiv, USA) at least three different times and testedindependently to ensure consistency across batches. ... Primary Screening ofthe ChemDiv Protease Inhibitor Library The ChemDiv proteaseinhibitor library was screened against RVFV strain MP12 at 20 μM in 0.5%(v/v) DMSO. ... Screening of the ChemDiv Protease InhibitorLibrary A total of 849 compounds from ChemDiv proteaseinhibitor library were used for antiviral screening.
Peter M.-U. Ung; James B. Dunbar; Jason E.Gestwicki;Heather A.Carlson
PMC ID: PMC4136727 | DOI: 10.1021/jm5008352 |ISSN: 0022-2623 | Journal: Journal of Medicinal Chemistry, 57(1) pp. 6468-6478 |Publisher: AmericanChemical Society | Publicationdate: 2014-07-25 | Print publication date: 2014-08-14
Originaldocument: PMC | Score: 18.065512 | Text size: 57809 | Find: similardocuments
the querysearches against academic and commercial chemical libraries: ChemBridge(2007), ChemDiv (2007), MayBridge (2007), and the CCG(2007.10) chemical libraries. ... solubility, cost, and availability from thevendors (CCG, 5 compounds; ChemBridge, 30 compounds; ChemDiv, 8compounds; MayBridge, 5 compounds). ... and libraries of three commercialvendors: ChemBridge (EXPRESS-Pick v2007, ∼50000 compounds), ChemDiv(2007,∼120000compounds), and MayBridge (v2007, ∼56000 compounds) chemical libraries. ... Finally, 48 compounds (5 from CCG,30 from ChemBridge, 8 from ChemDiv, and 5 from MayBridge) werepurchased for experimental testing (listed in Table S1 of
Mechanisms of Neuroblastoma Cell Growth Inhibition by CARP-1 FunctionalMimetics
Magesh Muthu; Vino T. Cheriyan; Sara Munie; Edi Levi; John Frank; Abdelkader E.Ashour;Mandip Singh; Arun K. Rishi; Surinder K.Batra
PMC ID: PMC4102511 | DOI: 10.1371/journal.pone.0102567 |Journal: PLoS ONE, 9(1) | Publisher: PublicLibrary of Science | Publicationdate: 2014-07-17
Originaldocument: PMC | Score: 13.317075 | Text size: 68438 | Find: similar documents
CFM-1, -4and -5 were obtained from ChemDiv, San Diego, and Ryan Scientific,Inc., Mt.
Dong-Hoon Chung; Colleen B.Jonsson;Nichole A. Tower; Yong-Kyu Chu; Ergin Sahin; Jennifer E.Golden;James W. Noah; Chad E.Schroeder;Julie B. Sotsky; Melinda I. Sosa; Daniel E. Cramer; Sara N. McKellip; Lynn Rasmussen; E. Lucile White; Connie S.Schmaljohn;Justin G.Julander;Jeffrey M. Smith; Claire MarieFilone;John H. Connor; Yasuteru Sakurai; Robert A. Davey; Timothy L.Tellinghuisen
PMC ID: PMC4072787 | DOI: 10.1371/journal.ppat.1004213 |ISSN: 1553-7366 | Journal: PLoS Pathogens, 10(1) | Publisher: PublicLibrary of Science | Publicationdate: 2014-06-26
Originaldocument: PMC | Score: 14.117049 | Text size: 50437 | Find: similardocuments
Synthesis ofquinazolinone CID15997213 CID15997213 is commercially available from ChemDiv,Inc. (CAS# 900134-28-3); however, it was synthesized at the Universityof Kansas for the purpose of
Yue Wang; Ming Yan; Guang-yao Zheng; Ling He; Huan Yang
PMC ID: PMC4088278 | DOI: 10.1038/aps.2014.21 |ISSN: 1671-4083 | Journal: Acta Pharmacologica Sinica, 35(1) pp. 957-966 |Publisher:NaturePublishing Group | Publication date: 2014-06-16 | Printpublication date: 2014-07
Originaldocument: PMC | Score: 14.2392435 | Text size: 41510 | Find: similardocuments
The testedcompounds were obtained from ChemDiv, Inc (San Diego, CA,USA).
Erin K. Sully; NataliaMalachowa;Bradley O.Elmore;Susan M.Alexander;Jon K. Femling; Brian M. Gray; Frank R. DeLeo; Michael Otto; Ambrose L.Cheung;Bruce S. Edwards; Larry A. Sklar; Alexander R.Horswill;Pamela R. Hall; Hattie D.Gresham;Eric P. Skaar
PMC ID: PMC4055767 | DOI: 10.1371/journal.ppat.1004174 |ISSN: 1553-7366 | Journal: PLoS Pathogens, 10(1) | Publisher: Public Library of Science | Publicationdate: 2014-06-12
Originaldocument: PMC | Score: 13.104898 | Text size: 80402 | Find: similardocuments
sulfonyl-1H-triazolo[1,5-a] quinazolin-5-one, CID#3243271) was synthesized by ChemDiv,confirmed purified by HPLC, and stored in DMSO at −80°C.
Beta-Catenin Regulated ALDH1A1 is a Target in Ovarian Cancer Spheroids
SalvatoreCondello;Cynthia A.Morgan;Sarbajeet Nagdas; Liyun Cao; John Turek; Thomas D. Hurley; Daniela Matei
PMC ID: PMC4275429 | DOI: 10.1038/onc.2014.178 |ISSN: 0950-9232 | Journal: Oncogene, 34(1) pp. 2297-2308 |Publicationdate: 2014-06-05 | Print publication date: 2015-04-30
Originaldocument: PMC | Score: 17.397476 | Text size: 60472 | Find: similardocuments
We used anovel ALDH1A1 inhibitor (A37) identified through high throughput screening ofthe ChemDiv library and the less selective inhibitor DEAB. A37has a molecular weight of 431. ... The ALDH1A1 inhibitor (A37) was from ChemDiv (SanDiego, CA, USA), having >95% purity. ... A high-throughput screen (HTS) of64,000 compounds from the ChemDiv Corp. was performed toidentify activators and inhibitors of ALDH1A1.
Hyung Jin Ahn; J. FraserGlickman;Ka Lai Poon; DariaZamolodchikov; Odella C.Jno-Charles;Erin H. Norris; SidneyStrickland
PMC ID: PMC4042638 | DOI: 10.1084/jem.20131751 |ISSN: 0022-1007 | Journal: The Journal of Experimental Medicine, 211(1) pp.1049-1062|Publisher: The Rockefeller University Press | Publicationdate: 2014-06-02 | Print publication date: 2014-06-02
Originaldocument: PMC | Score: 13.648543 | Text size: 64554 | Find: similardocuments
Vendor listfor primary screening library Provider No. of compound from each provider ChemDiv 21,986Prestwick 1,110 Cerep 4,000 ChemBridge 5,000 Microsource 2,000 AMRI 50,000Biofocus
Identification of Small-Molecule Frequent Hitters from AlphaScreenHigh-Throughput Screens
Kenji Schorpp; Ina Rothenaigner; Elena Salmina; JeanetteReinshagen;Terence Low; Jara K. Brenke; JayGopalakrishnan; Igor V. Tetko; Sheraz Gul;Kamyar Hadian
PMC ID: PMC4153540 | DOI: 10.1177/1087057113516861 |ISSN: 1087-0571 | Journal: Journal of Biomolecular Screening, 19(1) pp. 715-726 |Publisher: SAGEPublications | Publicationdate: 2014-06 | Print publication date: 2014-06
Originaldocument: PMC | Score: 14.2392435 | Text size: 49966 | Find: similardocuments
library usedin the HTS campaigns was composed of compounds acquired from threeproviders—namely,ChemDiv (San Diego, CA; 10,000 compounds), EnamineLtd.
Anna Lundin; Ronald Dijkman; TomasBergström; Nina Kann; Beata Adamiak; Charles Hannoun; Eveline Kindler; Hulda R.Jónsdóttir; Doreen Muth;Joeri Kint; Maria Forlenza; Marcel A.Müller;ChristianDrosten;Volker Thiel; Edward Trybala; Andrew Pekosz
PMC ID: PMC4038610 | DOI: 10.1371/journal.ppat.1004166 |ISSN: 1553-7366 | Journal: PLoS Pathogens, 10(1) | Publisher: PublicLibrary of Science | Publicationdate: 2014-05-29
Originaldocument: PMC | Score: 13.317075 | Text size: 80136 | Find: similar documents
Hit compoundK22 was purchased from ChemDiv (San Diego, CA; catalog number4295–0370).
Krisztina Dobi; IstvánHajdú; BeátaFlachner;GabriellaFabó;MáriaSzaszkó; MelindaBognár; Csaba Magyar; IstvánSimon;DánielSzisz;ZsoltLőrincz; SándorCseh;GyörgyDormán
PMC ID: PMC6270928 | DOI: 10.3390/molecules19067008 |Journal: Molecules, 19(1) pp. 7008-7039 |Publisher: MDPI | Publicationdate:2014-05-28
Originaldocument: PMC | Score: 14.490094 | Text size: 53589 | Find: similardocuments
availablefrom the actual edition of the top vendor databases (~5 million compounds):ChemBridge, ChemDiv, Asinex, Enamine, IfLab, UkrOrg, AMRI, Specs,Maybridge, Interbioscreen
A Fragment-Based Method to Discover Irreversible Covalent Inhibitors ofCysteine Proteases
Stefan G.Kathman;Ziyang Xu; Alexander V.Statsyuk
PMC ID: PMC4113264 | DOI: 10.1021/jm500345q |ISSN: 0022-2623 | Journal: Journal of Medicinal Chemistry, 57(1) pp. 4969-4974 |Publisher: AmericanChemical Society | Publicationdate: 2014-05-28 | Print publication date: 2014-06-12
Originaldocument: PMC | Score: 14.5541935 | Text size: 31413 | Find: similardocuments
fromAccelrys, 94275 commercially available carboxylic acids were identified fromthe ChemBridge, ChemDiv, MayBridge, NCI, and Sigma-Aldrichlibraries using SMARTS query strings.
DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNAdamage response
Laureen Colis; Karita Peltonen; Paul Sirajuddin; Hester Liu; Sara Sanders; Glen Ernst; James C. Barrow; Marikki Laiho
PMC ID: PMC4147329 | Journal: Oncotarget, 5(1) pp. 4361-4369 |Publisher: Impact Journals LLC | Publicationdate: 2014-05-26
Original document: PMC | Score: 14.301138 | Text size: 32671 | Find: similardocuments
N-[2(dimethylamino)ethyl]-12-oxo(BMH-21) was obtained from ChemDiv, verified for purity using LC/MSmass spectrometry and 1H-NMR.
Bo Wang; Cameron D.Buchman;Liwei Li; Thomas D. Hurley; Samy O. Meroueh
PMC ID: PMC4114474 | DOI: 10.1021/ci5002026 |ISSN: 1549-9596 | Journal: Journal of Chemical Information and Modeling, 54(1)pp. 2105-2116 | Publisher: AmericanChemical Society | Publicationdate: 2014-05-25 | Print publication date: 2014-07-28
Originaldocument: PMC | Score: 17.614815 | Text size: 56294 | Find: similardocuments
The negativeset consisted of 5000 randomly selected compounds from the ChemDiv librarydocked to a pocket within the target of interest. ... The 5000 randomly pickedcompounds from ChemDiv library docked to ALDH2 crystalstructure were used as the negative set to build the SVMSP model. ... A focusedset of theChemDiv commercial library64 containing 50 000 compoundswere docked to each of the 50 snapshots by
Elizabeth MZipprer;McKinzie Neggers; Ambuj Kushwaha; KempaiahRayavara;Sanjay A Desai
PMC ID: PMC4078004 | DOI: 10.1186/1475-2875-13-184 |Journal: Malaria Journal, 13(1) pp. 184-184 |Publisher: BioMed Central |Publication date: 2014-05-18
Originaldocument: PMC | Score: 14.2392435 | Text size: 40362 | Find: similardocuments
exception ofthe specific PSAC inhibitor ISPA-28 (a dihydroisoxazole-5-carboxamidederivative from ChemDiv, San Diego, CA, USA).
The novel proteins Rng8 and Rng9 regulate the myosin-V Myo51 duringfission yeast cytokinesis
Ning Wang; Libera Lo Presti; Yi-Hua Zhu; Minhee Kang; Zhengrong Wu; Sophie G. Martin; Jian-Qiu Wu
PMC ID: PMC4018781 | DOI: 10.1083/jcb.201308146 |ISSN: 0021-9525 | Journal: The Journal of Cell Biology, 205(1) pp. 357-375 |Publisher:TheRockefeller University Press | Publicationdate: 2014-05-12 | Print publication date: 2014-05-12
Originaldocument: PMC | Score: 13.878843 | Text size: 86332 | Find: similardocuments
The Arp2/3inhibitor CK666 (ChemDiv; Nolen et al.
Anthony A.Emanuele;Nancy E. Adams; Yi-Chen Chen; Anthony T.Maurelli;George A. Garcia
PMC ID: PMC4050983 | DOI: 10.1038/ja.2014.10 |ISSN: 0021-8820 | Journal: The Journal of antibiotics, 67(1) pp. 379-386 |Publicationdate:2014-02-19 | Printpublication date: 2014-05
Originaldocument: PMC | Score: 19.076883 | Text size: 42995 | Find: similardocuments
Compoundsselected for reconfirmation screening were purchased from ChemDiv (7compounds, San Diego, CA) and Vitas-M Laboratory (3 compounds, Moscow, Russia).... Small Molecule Library A 100,000 compound library produced by ChemDiv (SanDiego, CA) was screened at the Center for Chemical Genomics (CCG, University ofMichigan Ann ... Non-cytotoxic Conc. (μM)3Bacterial GrowthInhibition4 19615 Vitas-M 14 6.25 2% @ 100 μM 144092 ChemDiv 236.25 13% @ 100 μM144143 ChemDiv 23 6.25 14% @ 100 μM 153578ChemDiv 3712.5 19% @ 100 μM24904 ChemDiv 66 50 13% @ 50 μM 1Compounds 25354, 3776,25073, 16977 and 21496 did not reconfirm and were not
Identification of Novel Serotonin Transporter Compounds by VirtualScreening
Mari Gabrielsen; RafałKurczab;Agata Siwek; MałgorzataWolak;Aina W. Ravna; Kurt Kristiansen; Irina Kufareva; Ruben Abagyan; Gabriel Nowak;ZdzisławChilmonczyk;Ingebrigt Sylte; Andrzej J.Bojarski
PMC ID: PMC3982395 | DOI: 10.1021/ci400742s |ISSN: 1549-9596 | Journal: Journal of Chemical Information and Modeling, 54(1)pp. 933-943|Publisher: American Chemical Society | Publicationdate: 2014-02-12 | Print publication date: 2014-03-24
Originaldocument: PMC | Score: 16.735006 | Text size: 51913 | Find: similardocuments
and buildingblock collections of five commercial databases were screened: Asinex,40ChemBridge,41ChemDiv,42 Enamine,43 and Life Chemicals. ... first step ofthe VS protocol, screening of the druglike subsets of the Asinex,40ChemBridge,41 ChemDiv,42 Enamine,43 and Life Chemicals44 databasesusing 2D pharmacophore-based fingerprints and
Sommer S. Zimmerman; Alpa Khatri; Ethel C. Garnier-Amblard; PraseedaMullasseril;Natalie L.Kurtkaya;Stefka Gyoneva; Kasper B. Hansen;Stephen F.Traynelis;Dennis C. Liotta
PMC ID: PMC3983368 | DOI: 10.1021/jm401695d |ISSN: 0022-2623 | Journal: Journal of Medicinal Chemistry, 57(1) pp. 2334-2356 |Publisher: AmericanChemical Society | Publicationdate: 2014-02-10 | Print publication date: 2014-03-27
Originaldocument: PMC | Score: 12.899377 | Text size: 127425 | Find: similardocuments
Receptors Afluorescence-based screen of 57504 compounds obtained from Asinex and ChemDiv librarieswas performed in BHK cells with inducible expression of GluN1/GluN2C receptors.
Ann C.Kimble-Hill;Bibek Parajuli; Che-Hong Chen; DariaMochly-Rosen; Thomas D. Hurley
PMC ID: PMC3954746 | DOI: 10.1021/jm401377v |ISSN: 0022-2623 | Journal: Journal of Medicinal Chemistry, 57(1) pp. 714-722 |Publisher:AmericanChemical Society | Publicationdate: 2014-01-20 | Print publication date: 2014-02-13
Originaldocument: PMC | Score: 17.583435 | Text size: 45337 | Find: similardocuments
this groupof compounds further, we obtained an additional 33 structurally similaranalogues from ChemDivand ChemBridge and evaluated their ability toinhibit ALDH1A1, ALDH2, and ALDH3A1 using ... The following compounds werepurchased from ChemDiv for further screening: 0764-0625,1-pentyl-2,3-dihydro-1H-indole-2,3-dione (compound 2); ... Inhibitors thatemerged from the screens were purchased from ChemBridge orChemDiv.
In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors
Yaxue Zhao; Qingqing Meng; Linquan Bai; Huchen Zhou
PMC ID: PMC3907873 | DOI: 10.3390/ijms15011358 |Journal: International Journal of Molecular Sciences, 15(1) pp.1358-1373 | Publisher:Molecular Diversity Preservation International(MDPI) |Publicationdate: 2014-01-20
Originaldocument: PMC | Score: 14.618862 | Text size: 35215 | Find: similardocuments
When thispharmacophore was used to search the ChemDiv diversecollection database [53], thirty-one compounds were identified.
Identification of Clinically Viable Quinolinol Inhibitors of BotulinumNeurotoxin A Light Chain
DejanCaglič;Michelle C.Krutein;Kristin M. Bompiani; Deborah J.Barlow;Galit Benoni; Jeffrey C.Pelletier;Allen B. Reitz; Luke L. Lairson; Karen L.Houseknecht;Garry R. Smith; Tobin J.Dickerson
PMC ID: PMC3983388 | DOI: 10.1021/jm4012164 |ISSN: 0022-2623 | Journal: Journal of Medicinal Chemistry, 57(1) pp. 669-676 |Publisher:AmericanChemical Society | Publicationdate: 2014-01-05 | Print publication date: 2014-02-13
Originaldocument: PMC | Score: 16.60829 | Text size: 39082 | Find: similardocuments
A range ofquinolinol compounds are commercially available from ChemDiv andChemBridge small molecule repositories and were included into a screening setbased on the ... Purity of ChemDiv compounds was confirmed bythe supplier by LC/MS and NMR and had a purity of >95%.
In Vitro Evaluation of Novel Inhibitors against the NS2B-NS3 Protease ofDengue Fever Virus Type 4
Thi Thanh HanhNguyen;Sun Lee; Hsi-Kai Wang; Hsin-Yen Chen; Ying-Ta Wu; Simon C. Lin; Do-Won Kim; Doman Kim
PMC ID: PMC6269914 | DOI: 10.3390/molecules181215600 |Journal: Molecules, 18(1) pp. 15600-15612 |Publisher: MDPI | Publicationdate: 2013-12-13
Originaldocument: PMC | Score: 16.863674 | Text size: 31340 | Find: similardocuments
The NS3prodocking library comprised 300,000 compounds from ChemDiv Inc. (SanDiego, CA, USA), a commercially available compound library, was used for VS.... Sample Availability: All tested compounds are commercially availablefrom ChemDiv Inc. (San Diego, CA, USA).
PITPs as Targets for Selectively Interfering With PhosphoinositideSignaling in Cells
Aaron H. Nile; AshutoshTripathi;Peihua Yuan; Carl J. Mousley; Sundari Suresh; Iain MichaelWallace;Sweety D. Shah; Denise TeoticoPohlhaus;Brenda Temple; Corey Nislow; Guri Giaever; AlexanderTropsha;Ronald W. Davis; Robert P. StOnge;Vytas A.Bankaitis
PMC ID: PMC4059020 | DOI: 10.1038/nchembio.1389 |ISSN: 1552-4450 | Journal: Nature chemical biology, 10(1) pp. 76-84 |Publicationdate: 2013-11-24 | Print publication date: 2014-01
Originaldocument: PMC | Score: 13.878843 | Text size: 72104 | Find: similardocuments
Smallmolecule inhibitors The compounds shown in Supplementary Figure 1 werefrom ChemDiv (San Diego, CA).
Ronald P Trible; PurushottamNarute;Lori AEmert-Sedlak; John JeffAlvarado;Katelyn Atkins; Laurel Thomas; Toshiaki Kodama; Naveena Yanamala;VasiliyKorotchenko;Billy W Day; Gary Thomas; Thomas ESmithgall
PMC ID: PMC3874621 | DOI: 10.1186/1742-4690-10-135 |Journal: Retrovirology, 10(1) pp. 135-135 |Publisher: BioMed Central |Publication date: 2013-11-14
Originaldocument: PMC | Score: 17.869274 | Text size: 72190 | Find: similardocuments
μl) wereplated in duplicate wells of a 96-well plate in the presence of each compoundfrom the ChemDivkinase-biased inhibitor library (ChemDiv, Inc.,San Diego, CA). All compounds were initially screened at 10 μM with 0.5%DMSO as carrier solvent. ... observed with A-419259 were obtained in powderform from the provider of the original library (ChemDiv) and assayed athird time in triplicate at 1, 3, 10, and 30 μM in comparison with 5 μM A-419259.... The test compounds DQBS, 2,3-diaminoquinoxaline (ChemDiv) anddasatinib (LC Laboratories) were solubilized in DMSO and diluted into the DSFassays, followed
Turning Defense into Offense: Defensin Mimetics as Novel AntibioticsTargeting Lipid II
Kristen M.Varney;Alexandre M. J.J. Bonvin;Marzena Pazgier; Jakob Malin; Wenbo Yu; Eugene Ateh; Taiji Oashi; Wuyuan Lu; Jing Huang; MarliesDiepeveen-de Buin; Joseph Bryant; Eefjan Breukink; Alexander D.MacKerell;Erik P. H. deLeeuw;Michael Zasloff
PMC ID: PMC3820767 | DOI: 10.1371/journal.ppat.1003732 |ISSN: 1553-7366 | Journal: PLoS Pathogens, 9(1) | Publisher: Public Library of Science | Publicationdate: 2013-11-07 | Print publication date: 2013-11
Originaldocument: PMC | Score: 13.76273 | Text size: 68381 | Find: similardocuments
databases;Maybridge (Thermo Fisher Scientific Inc., Wattham, MA), ChemBridge (San Diego,CA), and ChemDiv(San Diego, CA), which contain 59676, 482276, and533143 compounds, respectively.
Birdal Bilir; Omer Kucuk; Carlos S Moreno
PMC ID: PMC4228255 | DOI: 10.1186/1479-5876-11-280 |Journal: Journal of Translational Medicine, 11(1) pp. 280-280 |Publisher: BioMed Central | Publicationdate: 2013-11-04
Originaldocument: PMC | Score: 13.878843 | Text size: 47742 | Find: similardocuments
Louis, MO).iCRT-3, iCRT-5 and iCRT-14 were obtained from ChemDiv (SanDiego, CA). IWP-4 was purchased from Stemgent (San Diego, CA).
Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growththrough Innate Immunity
MarianneLucas-Hourani; Daniel Dauzonne; Pierre Jorda; GaëlleCousin;Alexandru Lupan; Olivier Helynck; GrégoryCaignard;GenevièveJanvier;GwénaëlleAndré-Leroux; Samira Khiar; Nicolas Escriou; PhilippeDesprès; Yves Jacob; HélèneMunier-Lehmann; FrédéricTangy;Pierre-OlivierVidalain;Ganes C. Sen
PMC ID: PMC3789760 | DOI: 10.1371/journal.ppat.1003678 |ISSN: 1553-7366 | Journal: PLoS Pathogens, 9(1) | Publisher: PublicLibrary of Science | Publicationdate: 2013-10-03 | Print publication date: 2013-10
Originaldocument: PMC | Score: 15.963614 | Text size: 82706 | Find: similardocuments
librariesacquired through Prestwick Chemical (1,120 compounds;www.prestwickchemical.com) andChemDiv (eu.chemdiv. ... Compoundsfrom Prestwick Chemical and ChemDiv were at 2 mg/ml, whichcorresponds to 6.32±2.8 mM (Prestwick Chemical), 5.57±0.89 (CDI) and 5.35±1.
ClémentCarré; CarolineJacquier;Anne-LaureBougé; Fabrice deChaumont;CorinneBesnard-Guerin; HélèneThomassin;Josette Pidoux; Bruno Da Silva; EleftheriaChalatsi;Sarah Zahra; Jean-ChristopheOlivo-Marin;HélèneMunier-Lehmann; ChristopheAntoniewski;HelenWhite-Cooper
PMC ID: PMC3760873 | DOI: 10.1371/journal.pone.0074296 |Journal: PLoS ONE, 8(1) | Publisher: PublicLibrary of Science | Publicationdate: 2013-09-03
Originaldocument: PMC | Score: 13.996932 | Text size: 54936 | Find: similardocuments
and 9360compounds (ATP-mimic library) and 4624 compounds (nucleoside-like library)from ChemDiv Inc(http://eu.chemdiv.com/).
Small molecule Plasmodium FKBP35 inhibitor as a potential antimalariaagent
AmaravadhiHarikishore;Makhtar Niang; Sreekanth Rajan; Peter RainerPreiser;Ho Sup Yoon
PMC ID: PMC3752609 | DOI: 10.1038/srep02501 |Journal: Scientific Reports, 3(1) | Publisher: NaturePublishing Group | Publicationdate:2013-08-26
Originaldocument: PMC | Score: 16.692554 | Text size: 46063 | Find: similardocuments
Uponscreening our in-house ADME property filtered 3D virtual database of ChemDiv commerciallibrary with this five feature structure based pharmacophore model (Fig. ...Pharmacophore screening on ChemDiv library resulted in afocused library of 13,000 molecules.
Huifang Hao; Yutaka Maeda; Takuya Fukazawa; Tomoki Yamatsuji; Munenori Takaoka; Xiao-Hong Bao; Junji Matsuoka; Tatsuo Okui; Tsuyoshi Shimo;Nagio Takigawa; Yasuko Tomono; Motowo Nakajima; Iris M.Fink-Baldauf; Sandra Nelson; William Seibel; Ruben Papoian; Jeffrey A.Whitsett;Yoshio Naomoto; Masaru Katoh
PMC ID: PMC3745462 | DOI: 10.1371/journal.pone.0071093 |Journal: PLoS ONE, 8(1) | Publisher: PublicLibrary of Science | Publicationdate: 2013-08-16
Original document: PMC | Score: 13.996932 | Text size: 40424 | Find: similardocuments
[2,1-beta][1],[3]thiazol-6-yl]-2H-chromen-2-one (hereafter iMDK) purchased from ChemDiv (SanDiego, CA) was dissolved in DMSO.
Didem Demirbas; Arlene R. Wyman; MasamiShimizu-Albergine; Ozgur Cakici; Joseph A. Beavo; Charles S.Hoffman;Gordon Chua
PMC ID: PMC3743849 | DOI: 10.1371/journal.pone.0071279 |Journal: PLoS ONE, 8(1) | Publisher: PublicLibrary of Science | Publicationdate: 2013-08-14
Originaldocument: PMC | Score: 18.948826 | Text size: 43543 | Find: similardocuments
leu1-32cgs2-2 pap1Δars1::pNMT1-PDE8Acat Small Molecules Small molecules were purchased fromChemDiv (SanDiego, CA; BC8-15: E973-0331, BC8-15A: E881-0067, BC8-15C: C301-5319). ...School ICCB Screening facility (Asinex 1, Biomol-TimTec1, Bionet 1, Bionet 2,CEREP, ChemBridge 3, ChemDiv 1, ChemDiv2, ChemDiv 3, ChemDiv 4, ChemDiv 6,Enamine 1, Enamine 2, I.F. Lab 2, Life Chemicals 1, MayBridge 1, MayBridge 2,MayBridge 3, ... of the 63 strong hits that produced OD values of >0.6 camefrom only six libraries (ChemBridge 3, ChemDiv 3, ChemDiv 4,Enamine 1, Enamine 2, and MayBridge 3) that represented 37% of the screenedcompounds.
Small-Molecule Inhibitors of toxT Expression in Vibrio cholerae
RebeccaAnthouard;Victor J. DiRita
PMC ID: PMC3735192 | DOI: 10.1128/mBio.00403-13 |Journal: mBio, 4(1) | Publisher: AmericanSociety of Microbiology | Publicationdate:2013-08-06
Originaldocument: PMC | Score: 16.524874 | Text size: 50364 | Find: similardocuments
pyrazol-6-one]were obtained from ChemDiv (San Diego, CA). ... displayeddose-dependent activity, the 50 most potent (a low GFP/OD600 value) wereordered from ChemDiv and similarly retested for effects ongrowth and toxT transcription and for effects on CT
Inhibition of Histo-blood Group Antigen Binding as a Novel Strategy toBlock Norovirus Infections
Xu-Fu Zhang; Ming Tan; Monica Chhabra; Ying-Chun Dai; Jarek Meller; Xi Jiang; Eugene A.Permyakov
PMC ID: PMC3716607 | DOI: 10.1371/journal.pone.0069379 |Journal: PLoS ONE, 8(1) | Publisher: PublicLibrary of Science | Publicationdate: 2013-07-19
Originaldocument: PMC | Score: 14.490094 | Text size: 37822 | Find: similardocuments
(http://www.molport.com) supplied by Maybridg, TimTec, ChemBridge, Pharmeks, Specs, Otava, ChemDiv,InterBioScreen Ltd, Vitas-M Laboratory, Princeton Biomolecular Research andEnamine Ltd.
Structure-based discovery of fiber-binding compounds that reduce thecytotoxicity of amyloid beta
Lin Jiang; Cong Liu; David Leibly; Meytal Landau; Minglei Zhao; Michael P Hughes; David SEisenberg;John Kuriyan
PMC ID: PMC3713518 | DOI: 10.7554/eLife.00857 |Journal: eLife, 2(1) | Publisher: eLifeSciences Publications, Ltd | Publicationdate: 2013-07-16
Originaldocument: PMC | Score: 17.724873 | Text size: 88775 | Find: similardocuments
5 ± 8ZINC28616347 BAF17 C23H25N5O2 404 Sigma-Aldrich 6 ± 3 ZINC00579168 BAF18C24H16O2 336ChemDiv 6 ± 2 ZINC02168932 BAF19 C18H14N2O6 354 ChemDiv 3± 4 ZINC01507439 BAF20 C25H19N5OS 438 ChemDiv 8 ± 4ZINC15859747 BAF21 C19H14Br2O 418 ChemDiv 6 ± 3 ZINC38206526BAF22 C21H16N2O3S2 408 Life Chemicals 3 ± 5 ZINC04496365 BAF23 C16H11ClO5S 351
Igor V. Tetko; SergiiNovotarskyi;Iurii Sushko; Vladimir Ivanov; Alexander E.Petrenko;Reiner Dieden; Florence Lebon; Benoit Mathieu
PMC ID: PMC3760295 | DOI: 10.1021/ci400213d |ISSN: 1549-9596 | Journal: Journal of Chemical Information and Modeling, 53(1)pp. 1990-2000 | Publisher: AmericanChemical Society | Publicationdate: 2013-07-15 | Print publication date: 2013-08-26
Originaldocument: PMC | Score: 14.5541935 | Text size: 58439 | Find: similardocuments
A previousestimation of inconsistencies in DMSO solubility measurements has been reportedby the ChemDivcompany: a random re-evaluation of their datarevealed a 1% error rate.
William T.Berger;Brian P. Ralph; Martin Kaczocha; Jing Sun; Trent E. Balius; Robert C. Rizzo; SamirHaj-Dahmane;Iwao Ojima; Dale G. Deutsch;AlbericoCatapano
PMC ID: PMC3517626 | DOI: 10.1371/journal.pone.0050968 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-12-07
Originaldocument: PMC | Score: 19.39129 | Text size: 49852 | Find: similardocuments
The mostpotent inhibitor, γ-truxillicacid 1-naphthyl ester (ChemDiv 8009-2334), was determined to haveKi value of 1.19±0.01 μM. ...include: (1) Screen approximately one million compounds using a subset of theZINC [12] database (ChemDiv. ... the 48 compounds tested, 23 showed atleast 25% inhibition and 4 compounds, having the following ChemDiv ID(Stony Brook ID) numbers 5511-0235 (SB-FI-19), 8009-2334 (SB-FI-26 orSB-FI-49), 8009-7646 ... Overall, four compounds from the ChemDiv compoundlibrary were identified as potential competitive inhibitors of FABP5. The mostpotent compound, ChemDiv 8009-2334, was found to possess adiphenyl-cyclobutane core characteristic of the known natural
Simon E Alfred; AnuradhaSurendra;Chris Le; Ken Lin; Alexander Mok; Iain M Wallace; Michael Proctor; Malene L Urbanus; Guri Giaever; Corey Nislow
PMC ID: PMC3580497 | DOI: 10.1186/gb-2012-13-11-r105 |ISSN: 1465-6906 | Journal: Genome Biology, 13(1) pp. R105-R105 |Publisher:BioMedCentral | Publicationdate: 2012-11-18 | Print publication date: 2012
Originaldocument: PMC | Score: 16.60829 | Text size: 52782 | Find: similardocuments
that wecollated based on yeast growth inhibition from ChemBridge (NOVACore and DIVERSet)and ChemDiv(Divers) collections [38] (Table S2 in Additional file2). ... yeast actives set derived from ChemBridge (NOVACore and DIVERSet, SanDiego, CA, USA) and ChemDiv (Divers, San Diego, CA, USA), andtwo stock plates from ChemBridge (NOVACore, San Diego, CA, USA).
Identification of Small Molecules That Suppress Ricin-InducedStress-Activated Signaling Pathways
Paul G. Wahome; Sarita Ahlawat; Nicholas J.Mantis;Ludger Johannes
PMC ID: PMC3486792 | DOI: 10.1371/journal.pone.0049075 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-11-01
Originaldocument: PMC | Score: 18.140217 | Text size: 41649 | Find: similardocuments
pure compoundsfrom the commercially available chemical libraries (Actimol TimTec,Bionet, ChemDiv, CEREP, Enamine, I.F. Lab, Maybridge, and Peakdale)was performed at the National Screening ... cell-based assay at the NSRB toscreen more than 118,000 compounds in the Actimol TimTec, Bionet, ChemDiv,CEREP, Enamine, I. F. Lab, Maybridge, and Peakdale libraries for inhibitors ofricin toxin [16]. ... 9 PW69 6-oxo-N-(1-phenylbutan-2-yl)-5H-benzo[b][1], [4]benzothiazepine-3-carboxamide 6623219b ChemDiv 23 PW69B 6-oxo-N-(4-phenylbutan-2-yl)-5H-benzo[b][1],[4] benzothiazepine-3-carboxamide 20885127b ChemDiv 22 PW721-[3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,
Qi Zhang; Derong Ding; Shelya X. Zeng; Qi-Zhuang Ye; Hua Lu; Hirofumi Arakawa
PMC ID: PMC3480348 | DOI: 10.1371/journal.pone.0046294 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-10-24
Originaldocument: PMC | Score: 13.996932 | Text size: 50141 | Find: similardocuments
Materialsand Methods Compounds S1–S34 INZ analogs S1–S34 were purchased fromAsinex, ChemDiv and ChemBridge.
Identification of Fungicidal 2,6-Disubstituted Quinolines with Activityagainst Candida Biofilms
Nicolas Delattin; DorothéeBardiot;Arnaud Marchand; Patrick Chaltin; Katrijn DeBrucker;Bruno P. A.Cammue;Karin Thevissen
PMC ID: PMC6268363 | DOI: 10.3390/molecules171012243 |Journal: Molecules, 17(1) pp. 12243-12251 |Publisher: MDPI | Publicationdate: 2012-10-18
Originaldocument: PMC | Score: 14.684109 | Text size: 21705 | Find: similardocuments
(18) werepurchased from ChemDiv (San Diego, CA, USA). Synthesis of theamide derivatives has been described previously [14].
Sun Gwan Hwang; Jinah Park; Joo Young Park; Cheol HyoungPark;Ki-Ho Lee; Jeong Woo Cho; Jong-Ik Hwang; Jae Young Seong; Aamir Ahmad
PMC ID: PMC3441512 | DOI: 10.1371/journal.pone.0044259 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-09-13
Originaldocument: PMC | Score: 13.878843 | Text size: 49359 | Find: similardocuments
compoundlibrary consisted of 200,000 chemicals provided by the ChemBridge (San Diego,CA, USA),ChemDiv (San Diego, CA, USA), and Asinex (Moscow, Russia)chemical libraries.
Mining collections of compounds with Screening Assistant 2
Vincent LeGuilloux;Alban Arrault; LionelColliandre;StéphaneBourg;Philippe Vayer; Luc Morin-Allory
PMC ID: PMC3547782 | DOI: 10.1186/1758-2946-4-20 |Journal: Journal of Cheminformatics, 4(1) pp. 20-20 |Publisher: BioMed Central |Publication date: 2012-08-31
Originaldocument: PMC | Score: 14.74994 | Text size: 65469 | Find: similardocuments
ChemDiv (CU=54.97%,SU=45.23% and FU=31.49%).
Iurii Sushko; Elena Salmina; Vladimir A.Potemkin;Gennadiy Poda; Igor V. Tetko
PMC ID: PMC3640409 | DOI: 10.1021/ci300245q |ISSN: 1549-9596 | Journal: Journal of Chemical Information and Modeling, 52(1)pp. 2310-2316 | Publisher: AmericanChemical Society | Publicationdate: 2012-08-10 | Print publication date: 2012-08-27
Originaldocument: PMC | Score: 18.995876 | Text size: 34364 | Find: similardocuments
ToxAlertsplatform, we virtually screened screening libraries from three providers ofchemicals: ChemDiv ( www.chemdiv.com), LifeChemicals (www.lifechemicals.com), and Enamine ( www.enamine. ... by the company and builtaround 2181 original templates.21 The largest compound library was from ChemDiv andcontained almost 400 000 chemical structures available in stock from thiscompany. ... and Set of Structural Alerts from Three Different Providersprovideralertsscreening compounds ChemDiv alerts 100 391145Life Chemicals alerts 72 343949 Enamine alerts 108 228899 Screening Results The... Results for Three Compound Libraries and DrugBank against Three Sets ofStructural Alertsa ChemDiv compounds Life Chemicals compoundsEnamine compounds DrugBank compounds alerts settotal
Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51
Shamila S.Gunatilleke;Claudia M.Calvet;Jonathan B.Johnston;Chiung-KuangChen;Grigori Erenburg; Jiri Gut; Juan C. Engel; Kenny K. H. Ang;Joseph Mulvaney; Steven Chen; Michelle R.Arkin;James H.McKerrow;Larissa M.Podust;Michael P.Pollastri
PMC ID: PMC3409115 | DOI: 10.1371/journal.pntd.0001736 |ISSN: 1935-2727 | Journal: PLoS Neglected Tropical Diseases, 6(1)
Originaldocument: PMC | Score: 16.279572 | Text size: 67554 | Find: similardocuments
consistingof 103,986 diverse small molecules purchased from ChemBridge (San Diego,California), ChemDiv(San Diego, California) and SPECS (Delft,Netherlands) was screened against recombinant T. cruzi ...{α-[(4-methylcyclohexyl)carbonylamino]-N-4-pyridinyl-1H-indole-3-propanamide}purchased from ChemDiv (#C155-0123) (San Diego, California), referenced previously as LP-10 [14], [23],[26], was used as
Development of a High-Throughput Assay for Identifying Inhibitors of TBK1and IKKε
Jessica E. Hutti; Melissa A.Porter;Adam W. Cheely; Lewis C. Cantley; Xiaodong Wang; Dmitri Kireev; Albert S.Baldwin;William P.Janzen;Edward Harhaj
PMC ID: PMC3408500 | DOI: 10.1371/journal.pone.0041494 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-07-30
Original document: PMC | Score: 14.618862 | Text size: 34916 | Find: similardocuments
than 100Kcompounds were initially reviewed in the form of SD files from LifeChemicals, ChemDiv, Asinex and Enamine.
JenvitPatanayindee; ChatchaiMuanprasat;SunhapasSoodvilai;VaranujChatsudthipong
PMC ID: PMC3480796 | DOI: 10.4103/0253-7613.100392 |ISSN: 0253-7613 | Journal: Indian Journal of Pharmacology, 44(1) pp. 619-623 |Publisher: MedknowPublications & Media Pvt Ltd | Publicationdate: 2012 | Print publication date: 2012
Originaldocument: PMC | Score: 14.5541935 | Text size: 22203 | Find: similardocuments
(UT, USA);carbachol, amiloride, and amphotericin B from Sigma-Aldrich (MO, USA); and DQAfrom ChemDiv(CA, USA).
Characterization of Plasmodium falciparum Adenylyl Cyclase-
Eric Salazar; Erin M. Bank; Nicole Ramsey; Kenneth C. Hess; Kirk W. Deitsch; Lonny R. Levin; Jochen Buck; Stuart AlexanderRalph
PMC ID: PMC3383692 | DOI: 10.1371/journal.pone.0039769 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-06-26
Originaldocument: PMC | Score: 14.301138 | Text size: 42743 | Find: similardocuments
of WeillMedical College of Cornell University, and other KH7-like compounds werepurchased from ChemDiv(San Diego, CA).
Arp2/3 complex–dependent actin networks constrain myosin II function indriving retrograde actin flow
Qing Yang; Xiao-Feng Zhang; Thomas D.Pollard;Paul Forscher
PMC ID: PMC3384413 | DOI: 10.1083/jcb.201111052 |ISSN: 0021-9525 | Journal: The Journal of Cell Biology, 197(1) pp. 939-956 |Publisher:TheRockefeller University Press | Publicationdate: 2012-06-25 | Print publication date: 2012-06-25
Originaldocument: PMC | Score: 13.42576 | Text size: 75678 | Find: similardocuments
CK666 waspurchased from ChemDiv, Inc. CK689, CK869, CK312,blebbistatin, and Y27632 were purchased from EMD.
Mila BrumOrtigoza;Oliver Dibben; Jad Maamary; LuisMartinez-Gil; Victor H.Leyva-Grado;Pablo Abreu; Juan Ayllon; Peter Palese; Megan L. Shaw;Kanta Subbarao
PMC ID: PMC3343121 | DOI: 10.1371/journal.ppat.1002668 |ISSN: 1553-7366 | Journal: PLoS Pathogens, 8(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-04-26 | Print publication date: 2012-04
Originaldocument: PMC | Score: 18.045282 | Text size: 83571 | Find: similardocuments
Scientific,Mount Pleasant, SC), Chembridge 3 (10,560 compounds; ChemBridge Corp., SanDiego, CA),ChemDiv 2 (8,560 compounds; ChemDiv, Inc.,San Diego, CA), ChemDiv 4 (1,320 compounds; ChemDiv,Inc., San Diego, CA), Enamine 2 (26,576 compounds; ENAMINE Ltd. ...compounds; Maybridge Ltd., Trevillett, England), Mixed Commercial Plate 5 (268compounds from ChemDiv and Maybridge libraries), Peakdale 2(352 compounds; Peakdale Molecular Ltd.
IspE Inhibitors Identified by a Combination of In Silico and In VitroHigh-Throughput Screening
NaomiTidten-Luksch; RaffaellaGrimaldi;Leah S. Torrie; Julie A.Frearson;William N.Hunter;Ruth Brenk; RamónCampos-Olivas
PMC ID: PMC3340893 | DOI: 10.1371/journal.pone.0035792 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-04-25
Originaldocument: PMC | Score: 13.878843 | Text size: 66500 | Find: similardocuments
was ordered fromMaybridge (Fisher Scientific UK Ltd, Leicestershire, UK), compounds 2 and 3from ChemDiv(San Diego, USA), compounds 4, 7, 9, 11, 12, 13 fromEnamine Ltd.
The EYA Tyrosine Phosphatase Activity Is Pro-Angiogenic and Is Inhibitedby Benzbromarone
EmmanuelTadjuidje;Tim Sen Wang; Ram NareshPandey;Saulius Sumanas; Richard A. Lang; Rashmi S. Hegde; Justin Kumar
PMC ID: PMC3335822 | DOI: 10.1371/journal.pone.0034806 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-04-24
Original document: PMC | Score: 13.878843 | Text size: 54067 | Find: similardocuments
L129305) andcompounds 1b–1j from ChemDiv (cat. nos.
Qi Zhang; Shelya X Zeng; Yu Zhang; Yiwei Zhang; Derong Ding; Qizhuang Ye; Samy O Meroueh; Hua Lu
PMC ID: PMC3376857 | DOI: 10.1002/emmm.201100211 |ISSN: 1757-4676 | Journal: EMBO Molecular Medicine, 4(1) pp. 298-312 |Publisher: WILEY-VCHVerlag |Publicationdate: 2012-04 | Print publication date: 2012-04
Originaldocument: PMC | Score: 15.963614 | Text size: 72194 | Find: similardocuments
our initialcomputational screening of half a million of commercially available compoundsfrom the ChemDivchemical library, we selected and purchased 50 topcandidates. ... compounds for the cell-based screen, INZ and its analogues werepurchased from Asinex, ChemDiv and ChemBridge.
Identification of Novel Mt-Guab2 Inhibitor Series Active against M.tuberculosis
VeeraraghavanUsha;Judith V.Hobrath;Sudagar S.Gurcha;Robert C.Reynolds;Gurdyal S. Besra; Anil Kumar Tyagi
PMC ID: PMC3315515 | DOI: 10.1371/journal.pone.0033886 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-03-29
Originaldocument: PMC | Score: 18.756086 | Text size: 61499 | Find: similar documents
hits listedin Figure S3 that are available from Life Chemicals and a single compoundfrom ChemDiv. ... was purchased from the commercial vendorsChembridge (Chembridge set), Life Chemicals and ChemDiv (LifeChemicals set) and were used as supplied from the vendors without furthercharacterization or ... Life Chemicals compound set, consisting of seventeencompounds from Life Chemicals and one from ChemDiv. ... (UC) 71.3(UC) 6.70 >5.97 3 F2536-1573 79.0 (UC) 55.0 (UC) 1.02 6.68 >128 Compound1499-0691 fromChemDiv is also included in this set. ... Of theeighteen hits from the Life Chemicals and ChemDiv compoundset, seven compounds exhibited antimycobacterial activity against M. smegmatis,four of
A Chemical Screen Probing the Relationship between Mitochondrial Contentand Cell Size
Toshimori Kitami; David J. Logan; Joseph Negri; Thomas Hasaka; Nicola J.Tolliday;Anne E.Carpenter;Bruce M.Spiegelman;Vamsi K. Mootha;Yidong Bai
PMC ID: PMC3315575 | DOI: 10.1371/journal.pone.0033755 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-03-29
Original document: PMC | Score: 14.618862 | Text size: 31623 | Find: similardocuments
Commercial compounds:3520 drug-like libraries from TimTec, Maybridge, and ChemDiv.
Structure-Based Virtual Screening for Drug Discovery: a Problem-CentricReview
Tiejun Cheng; Qingliang Li; Zhigang Zhou; Yanli Wang; Stephen H.Bryant
PMC ID: PMC3282008 | DOI: 10.1208/s12248-012-9322-0 |Journal: The AAPS Journal, 14(1) pp. 133-141 |Publisher: Springer US |Publication date: 2012-01-27
Originaldocument: PMC | Score: 14.684109 | Text size: 51086 | Find: similardocuments
56,000http://www.maybridge.com WOMBAT Commercial 263,000http://www.sunsetmolecular.com ChemDivCommercial 1.5 millionhttp://www.chemdiv.com ChemNavigator Commercial 55.3 million http://www.
Defective CFTR-Dependent CREB Activation Results in ImpairedSpermatogenesis and Azoospermia
Wen Ming Xu; Jing Chen; Hui Chen; Rui Ying Diao; Kin Lam Fok; Jian Da Dong; Ting Ting Sun; Wen Ying Chen; Mei Kuen Yu; Xiao Hu Zhang; Lai Ling Tsang; Ann Lau; Qi Xian Shi; Qing Hua Shi; Ping Bo Huang; Hsiao Chang Chan; Irina Agoulnik
PMC ID: PMC3090391 | DOI: 10.1371/journal.pone.0019120 |Journal: PLoS ONE, 6(1) | Publisher: PublicLibrary of Science | Publication date: 2011-05-09
Originaldocument: PMC | Score: 14.117049 | Text size: 61054 | Find: similar documents
In someexperiment groups, 10 μM CFTRinh172(Sigma), 10 μM KH7 (ChemDiv),50 ng recombinant FSH were added to the media.
Anticancer activity of the iron facilitator LS081
Zhen Li; Hiroki Tanaka; Floyd Galiano; Jonathan Glass
PMC ID: PMC3077325 | DOI: 10.1186/1756-9966-30-34 |ISSN: 0392-9078 | Journal: Journal of Experimental & Clinical Cancer Research: CR, 30(1) pp. 34-34 | Publisher: BioMedCentral | Publicationdate: 2011-03-31
Originaldocument: PMC | Score: 16.44229 | Text size: 43845 | Find: similardocuments
The chemicallibraries were obtained from ChemDiv (San Diego, CA) andTimTec (Newark, DE). ... In the initial screening of the compounds obtained from ChemDiv thirtycompounds exhibited negative values for Δ Fn, i.e. Δ Fn <-50% and were therefore defined as
Esther Sala; Laura Guasch; JustynaIwaszkiewicz; Miquel Mulero; Maria-JosepaSalvadó; MontserratPinent;Vincent Zoete; AurélienGrosdidier;SantiagoGarcia-Vallvé; OlivierMichielin;Gerard Pujadas; Vladimir Uversky
PMC ID: PMC3044726 | DOI: 10.1371/journal.pone.0016903 |Journal: PLoS ONE, 6(1) | Publisher: PublicLibrary of Science | Publicationdate: 2011-02-24
Originaldocument: PMC | Score: 14.363574 | Text size: 71781 | Find: similardocuments
this sense,the results of the present study outperform those of a recent in silico surveyon the ChemDivdatabase (http://us.chemdiv.
Essential Metabolites of Mycobacterium tuberculosis and Their Mimics
Gyanu Lamichhane; Joel S.Freundlich;Sean Ekins; NilukaWickramaratne; Scott T. Nolan; William R.Bishai
PMC ID: PMC3031304 | DOI: 10.1128/mBio.00301-10 |Journal: mBio, 2(1) | Publisher: AmericanSociety of Microbiology | Publicationdate:2011-02-01
Originaldocument: PMC | Score: 14.2392435 | Text size: 56556 | Find: similardocuments
50 Bleomycin57 MIC=0.1 μg/ml CDDdatabase Hydroxymethylbilane ChemDiv 4286-0015d 45 IC50=3.38μMc CDDdatabase Porfimer 45 CDD database a Examples of biomolecules
Modular Chemical Descriptor Language (MCDL): Stereochemical modules
Andrei A Gakh; Michael NBurnett;Sergei VTrepalin;Alexander VYarkov
PMC ID: PMC3042968 | DOI: 10.1186/1758-2946-3-5 |Journal: Journal of Cheminformatics, 3(1) pp. 5-5 |Publisher: BioMed Central |Publication date: 2011-01-31
Originaldocument: PMC | Score: 14.783076 | Text size: 43276 | Find: similardocuments
Thefollowing differences were found in non-stereo testing of 20,000-records inthe ChemDiv database [26]: 1. Porphyrines.
Development and evaluation of human AP endonuclease inhibitors inmelanoma and glioma cell lines
M Z Mohammed; V N Vyjayanti; C A Laughton; L V Dekker; P M Fischer; D M Wilson; R Abbotts; S Shah; P M Patel; I D Hickson; S Madhusudan
PMC ID: PMC3049581 | DOI: 10.1038/sj.bjc.6606058 |ISSN: 0007-0920 | Journal: British Journal of Cancer, 104(1) pp. 653-663 |Publisher:NaturePublishing Group | Publicationdate: 2011-01-25 | Print publication date: 2011-02-15
Originaldocument: PMC | Score: 13.878843 | Text size: 53367 | Find: similardocuments
(Braunschweig,Germany), Enamine Ltd. (Kiev, Ukraine), Specs Chemicals (Delft, theNetherlands), ChemDiv Inc. (San Diego, CA, USA),Ukrorgsynthesis Ltd (Kiev, Ukraine) and Sigma-Aldrich.
Nayef Mazloum; Melanie A.Stegman;Deborah L.Croteau;Bennett VanHouten;Nyoun Soo Kwon; Yan Ling; CaitlynDickinson;Aditya Venugopal;Mohammad AtifTowheed;Carl Nathan
PMC ID: PMC3042777 | DOI: 10.1021/bi101674c |ISSN: 0006-2960 | Journal: Biochemistry, 50(1) pp. 1329-1335 |Publisher: American Chemical Society | Publicationdate: 2011-01-14 | Print publication date: 2011-03-01
Originaldocument: PMC | Score: 14.363574 | Text size: 42116 | Find: similardocuments
High-ThroughputScreening Thirty-eight thousand compounds with drug-like properties from ChemDiv andChembridge were screened at the Rockefeller University-Weill Cornell MedicalCollege High
Steven S An; Peter S Askovich; Thomas IZarembinski;Kwangmi Ahn; John M Peltier; Moritz vonRechenberg;SudhirSahasrabudhe; Jeffrey JFredberg
PMC ID: PMC3034681 | DOI: 10.1186/1465-9921-12-8 |ISSN: 1465-9921 | Journal: Respiratory Research, 12(1) pp. 8-8 |Publisher: BioMed Central | Publicationdate: 2011-01-13 | Print publication date: 2011
Originaldocument: PMC | Score: 14.426556 | Text size: 38390 | Find: similardocuments
58,019structurally diverse chemical compounds were obtained from ChemBridge (SanDiego, CA) andChemDiv (San Diego, CA).
An Efficient New Route to Dihydropyranobenzimidazole Inhibitors of HCVReplication
Matthew A.Parker;Emily Satkiewicz; Thomas Hermann; B. MikaelBergdahl
PMC ID: PMC6259416 | DOI: 10.3390/molecules16010281 |Journal: Molecules, 16(1) pp. 281-290 |Publisher: MDPI | Publicationdate:2010-12-30
Original document: PMC | Score: 14.74994 | Text size: 24925 | Find: similardocuments
LeRoyLafferty for NMR support, and ChemDiv, Inc., for a generousdonation of equipment and supplies.
ElizabethRico-Bautista; Chih-Cheng Yang; Lifang Lu; Gregory P Roth; Dieter A Wolf
PMC ID: PMC3025922 | DOI: 10.1186/1741-7007-8-153 |Journal: BMC Biology, 8(1) pp. 153-153 |Publisher: BioMed Central | Publicationdate: 2010-12-23
Originaldocument: PMC | Score: 13.317075 | Text size: 77402 | Find: similardocuments
SMIP0019 waspurchased from ChemDiv, Inc (CA, USA).
Targeting the OB-Folds of Replication Protein A with Small Molecules
Victor J.Anciano Granadillo; Jennifer N.Earley;Sarah C. Shuck; Millie M.Georgiadis;Richard W. Fitch; John J. Turchi
PMC ID: PMC3005895 | DOI: 10.4061/2010/304035 |ISSN: 2090-0201 | Journal: Journal of Nucleic Acids, 2010(1)
Originaldocument: PMC | Score: 14.117049 | Text size: 41167 | Find: similardocuments
SMIs wasidentified from screening and analysis of structure activity relationships(SARs) of the ChemDiv library [12].
IKKβ inhibitor identification: amulti-filter driven novel scaffold
Shanthi Nagarajan; Hyunah Choo; Yong Seo Cho; Kye Jung Shin; Kwang-Seok Oh; Byung Ho Lee; Ae Nim Pae
PMC ID: PMC2957683 | DOI: 10.1186/1471-2105-11-S7-S15 |Journal: BMC Bioinformatics, 11(1) pp. S15-S15 |Publisher: BioMed Central |Publication date: 2010-10-15
Originaldocument: PMC | Score: 17.805475 | Text size: 36287 | Find: similardocuments
virtualscreening (VS) technique has been applied to identify IKKβ inhibitorsfrom the ChemDiv database with 0.7 million compounds. ...investigation, we have applied various computational models sequentially tovirtually screen the ChemDiv database, and identified a smallmolecule that has an IC50 value of 20.3μM. ... Virtual Screening Byusing the above mentioned models, we have been able to filter the ChemDiv database,that has approximately 0.7 million compounds (Fig. 3).
Julia Oh; Eula Fung; Ulrich Schlecht; Ronald W. Davis; Guri Giaever; Robert P. St.Onge;AdamDeutschbauer; Corey Nislow; Scott G. Filler
PMC ID: PMC2951378 | DOI: 10.1371/journal.ppat.1001140 |ISSN: 1553-7366 | Journal: PLoS Pathogens, 6(1) | Publisher: PublicLibrary of Science | Publicationdate: 2010-10-07 | Print publication date: 2010-10
Originaldocument: PMC | Score: 13.76273 | Text size: 87594 | Find: similardocuments
Drugscreening A diversity library was obtained from ChemDiv, Inc. anddissolved in DMSO.
Navigating the Human Metabolome for Biomarker Identification and Designof Pharmaceutical Molecules
IreneKouskoumvekaki; GianniPanagiotou
PMC ID: PMC2948926 | DOI: 10.1155/2011/525497 |ISSN: 1110-7243 | Journal: Journal of Biomedicine and Biotechnology, 2011(1)
Originaldocument: PMC | Score: 17.21541 | Text size: 86538 | Find: similardocuments
drugs fromDrugBank v.2, as well as for a randomly selected subset of 59,025 compoundsfrom ChemDiv, a commercial provider of small compounds for drugdiscovery HTS. ... On the other hand, only 182 compounds from the subsetof ChemDiv were found similar to any human metabolite, formingjust 1,563 similarity pairs in total. This low similarity of ChemDiv couldbe attributed to the fact that HTS databases contain small molecules withsimple structures
Karita Peltonen; Laureen Colis; Hester Liu; SariJäämaa; Henna M. Moore; JuuliaEnbäck;Pirjo Laakkonen; Anne Vaahtokari; Richard J. Jones; Taija M. afHällström; Marikki Laiho; Joseph AlanBauer
PMC ID: PMC2946317 | DOI: 10.1371/journal.pone.0012996 |Journal: PLoS ONE, 5(1) | Publisher: PublicLibrary of Science | Publicationdate: 2010-09-27
Original document: PMC | Score: 13.996932 | Text size: 49987 | Find: similardocuments
Cells wereplated at 10,000 cells/well onto 96-well plates and treated at 3 μM (ChemDiv,Tripos) or 10 μM (SpectrumCollection) compound concentration for 24 h. Mock treatment (DMSO
Yow-Jiun Jeng; Cheryl S. Watson
PMC ID: PMC3018487 | DOI: 10.1289/ehp.1002512 |ISSN: 0091-6765 | Journal: Environmental Health Perspectives, 119(1) pp. 104-112 |Publisher: NationalInstitute of Environmental Health Sciences | Publication date: 2010-09-22 | Print publication date: 2011-01
Originaldocument: PMC | Score: 14.363574 | Text size: 46540 | Find: similardocuments
TheG-protein–coupled ER (GPER) agonist G1 was a gift from Chemdiv Inc. (SanDiego, CA) arranged by E. Prossnitz.
Reconstruction and flux-balance analysis of the Plasmodium falciparummetabolic network
GermánPlata;Tzu-Lin Hsiao; Kellen LOlszewski;ManuelLlinás; Dennis Vitkup
PMC ID: PMC2964117 | DOI: 10.1038/msb.2010.60 |Journal: Molecular Systems Biology, 6(1) pp. 408-408 |Publisher: Nature Publishing Group | Publicationdate: 2010-09-07
Originaldocument: PMC | Score: 16.360525 | Text size: 85455 | Find: similardocuments
Thecompounds 1_03 and 3_02 were acquired from ChemDiv (http://chemdiv.emolecules.com; ChemDiv IDs8003-6329 and 5350-0029, respectively) and resuspended at 100 mM in DMSO.
Discovery of a Novel Chemical Class of mGlu5 Allosteric Ligands withDistinct Modes of Pharmacology
Alexis S.Hammond;Alice L.Rodriguez;Steven D.Townsend;Colleen M. Niswender; Karen J. Gregory; Craig W. Lindsley; P. Jeffrey Conn
PMC ID: PMC2957851 | DOI: 10.1021/cn100051m |ISSN: 1948-7193 | Journal: ACS Chemical Neuroscience, 1(1) pp. 702-716 |Publisher:AmericanChemical Society | Publicationdate: 2010-08-19
Originaldocument: PMC | Score: 13.648543 | Text size: 65341 | Find: similardocuments
ScreeningCenter compound collection was obtained from ChemBridge Corporation (San Diego,CA) andChemDiv, Inc. (San Diego, CA). l-Glutamate and MPEP wereobtained from Tocris Bioscience (Ellisville, MO).
Enrico DeFranchi;Claire Schalon; Mirko Messa; Franco Onofri; Fabio Benfenati; Didier Rognan; Floyd Romesberg
PMC ID: PMC2922380 | DOI: 10.1371/journal.pone.0012214 |Journal: PLoS ONE, 5(1) | Publisher: PublicLibrary of Science | Publicationdate: 2010-08-16
Original document: PMC | Score: 14.2392435 | Text size: 55498 | Find: similardocuments
San Diego,CA), 70159800251 (Otava, kiev, Ukraine), H-89 (LC Laboratories, Woburn, MA),4072–7730 (ChemDiv, San Diego, CA), R59022 and novobiocin (MPBiochemicals, Illkirch, France) and last CCT018059
Identification of Small Molecule Inhibitors of Clostridium perfringens
Michelle Lewis; Charles DavidWeaver;Mark S. McClain
PMC ID: PMC2922765 | DOI: 10.3390/toxins2071825 |Journal: Toxins, 2(1) pp. 1825-1847 |Publisher: MDPI | Publicationdate: 2010-07-09
Originaldocument: PMC | Score: 18.45006 | Text size: 48439 | Find: similardocuments
compoundsrepresents a diverse subset of the >1 million member inventories of twocompanies, ChemDivand ChemBridge. Each chemical is dissolved at aconcentration of 10 mM in dimethylsulfoxide. Confirmed hits and theirstructural analogs were acquired from commercial sources (ChemDiv,ChemBridge, and Specs) as dry powders and dissolved in DMSO. ... VanderbiltInstitute of Chemical Biology HTS facility has chemical libraries from twosources, ChemDiv and ChemBridge. The 151,616 chemicalsscreened in this assay are representative of the chemical diversity of thelarger ChemDiv and ChemBridge compound collections.
Elina Mattila; Heidi Marttila; Niko Sahlberg; Pekka Kohonen; SiriTähtinen; Pasi Halonen; MerjaPerälä; Johanna Ivaska
PMC ID: PMC2820462 | DOI: 10.1186/1471-2407-10-7 |Journal: BMC Cancer, 10(1) pp. 7-7 |Publisher: BioMed Central | Publicationdate:2010-01-07
Originaldocument: PMC | Score: 18.470776 | Text size: 41249 | Find: similardocuments
DiscoverySystems, LOPAC (Library of Pharmacologically Active Compounds) 1280 fromSigma, ChemDiv fromChemDiv Inc., ChemBridge fromChemBridge Corporation, and Tripos from Tripos International. ... compounds,LOPAC1280 with 1280 pharmaceutically active compounds, Tripos with 6000 compounds,ChemDiv with25000 compounds and ChemBridge with 30000 compounds were screened in an invitro phosphatase ... LibraryCompoundsPrimary hitsConfirmed activators Tripos6000 5 1 ChemDiv 25000 23 1 ChemBridge 30000 167 0 MicrosourceSpectrum 2000 16 2 Sigma Lopac 1280 2 2 Total 64280 ... Five small moleculelibraries, the Spectrum Collection, LOPAC1280, ChemDiv, ChemBridgeand Tripos were screened for TCPTP activators.
Svetlana M. Sirko; Nikolay Yu.Gorobets;Vladimir I.Musatov;Sergey M.Desenko
PMC ID: PMC6254725 | DOI: 10.3390/molecules14125223 |Journal: Molecules, 14(1) pp. 5223-5234 |Publisher: Molecular Diversity Preservation International | Publication date: 2009-12-15
Originaldocument: PMC | Score: 14.951023 | Text size: 25352 | Find: similardocuments
AcknowledgementsWe thank ChemDiv, Inc. San Diego, CA, USA for supporting thiswork.
Molecular Mechanism for Human Sperm Chemotaxis Mediated by Progesterone
Maria E. Teves; Hector A.Guidobaldi;Diego R.Uñates; Raul Sanchez; Werner Miska; Stephen J.Publicover;Aduén A.Morales Garcia; Laura C.Giojalas;Immo A. Hansen
PMC ID: PMC2782141 | DOI: 10.1371/journal.pone.0008211 |Journal: PLoS ONE, 4(1) | Publisher: PublicLibrary of Science | Publicationdate: 2009-12-08
Originaldocument: PMC | Score: 13.996932 | Text size: 55740 | Find: similardocuments
USA); HumanSerum Albumin (UNC, Argentina); Nifedipine, 2-APB (Calbiochem, Germany); KH7 (ChemDiv,USA); mouse monoclonal anti-phosphotyrosine, clone 4G10 (UPSTATE, USA); rabbitpolyclonal
Physiochemical property space distribution among human metabolites, drugsand toxins
Varun Khanna; ShobaRanganathan
PMC ID: PMC2788350 | DOI: 10.1186/1471-2105-10-S15-S10 |Journal: BMC Bioinformatics, 10(1) pp. S10-S10 |Publisher: BioMed Central |Publication date: 2009-12-03
Originaldocument: PMC | Score: 16.524874 | Text size: 56456 | Find: similardocuments
set ofmolecules from NPs obtained from four databases namely BioSPECS natural productdatabase,ChemDiv natural product database, Interbioscreeen IBS2001Nand HTS-NC database, drugs obtained from ... obtained from (MayBridge HTSdatabase, ChemBridge EXPRESS-Pick database ComGenex Collection,ChemDiv Collectionand SPECS screening compound database).
Verena Fetz; Shirley K.Knauer;Carolin Bier; Jens Peter vonKries;Roland H.Stauber
PMC ID: PMC3274152 | DOI: 10.3390/s90705423 |Journal: Sensors (Basel, Switzerland), 9(1) pp. 5423-5445 |Publisher: Molecular Diversity Preservation International (MDPI) | Publication date: 2009-07-09
Originaldocument: PMC | Score: 13.996932 | Text size: 58089 | Find: similardocuments
Compoundswere purchased from ChemDiv (San Diego, CA, USA) and dissolvedin DMSO (50 mM).
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expandscardiac cell lineages
Gabriela Molina; Andreas Vogt; Ahmet Bakan; Weixiang Dai; Pierre Queirozde Oliveira;Wade Znosko; Thomas E.Smithgall;Ivet Bahar; John S. Lazo; Billy W. Day; Michael Tsang
PMC ID: PMC2771339 | DOI: 10.1038/nchembio.190 |ISSN: 1552-4450 | Journal: Nature chemical biology, 5(1) pp. 680-687 |Publicationdate: 2009-07-05 | Print publication date: 2009-09
Originaldocument: PMC | Score: 14.117049 | Text size: 44421 | Find: similar documents
the NaturalProducts library (MicroSource Discovery Systems Inc.) and Phosphatase targetedset (ChemDiv Inc.) were screened in this study.
ChristelleCabrol;Malwina A.Huzarska;ChristopherDinolfo;Maria C.Rodriguez;Lael Reinstatler; Jake Ni; Li-An Yeh; Gregory D. Cuny; Ross L. Stein;Dennis J. Selkoe; Malcolm A.Leissring;Andreas Hofmann
PMC ID: PMC2668070 | DOI: 10.1371/journal.pone.0005274 |Journal: PLoS ONE, 4(1) | Publisher: PublicLibrary of Science | Publicationdate: 2009-04-22
Originaldocument: PMC | Score: 14.363574 | Text size: 39120 | Find: similardocuments
(Ilkirch,France), Specs and Biospecs (CP Rijswijk, the Netherlands), ENAMINE (Kiev,Ukraine), and ChemDiv(San Diego, CA). Ia1 and Ia2 were purchasedfrom Bionet. SP1 was synthesized by SynPep Corp.
Chemical Probes that Competitively and Selectively Inhibit Stat3Activation
Xuejun Xu; Moses M.Kasembeli;Xueqing Jiang; Benjamin J.Tweardy;David J. Tweardy; Harald H. H. W.Schmidt
PMC ID: PMC2653189 | DOI: 10.1371/journal.pone.0004783 |Journal: PLoS ONE, 4(1) | Publisher: PublicLibrary of Science | Publicationdate: 2009-03-10
Originaldocument: PMC | Score: 16.44229 | Text size: 53112 | Find: similardocuments
Commercialchemical databases (ChemBridge, Asinex, ChemDiv, Enamine,KeyOrganics and LifeChemicals) were chosen as sources of compounds forscreening in ... The databases searched included ChemBridge, LifeChemicals,Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for atotal of 2.47 million compounds.
Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacteriumtuberculosis Screen Hit
Chiung-KuangChen;Patricia S.Doyle;Liudmila V.Yermalitskaya; Zachary B.Mackey;Kenny K. H. Ang; James H. McKerrow; Larissa M.Podust;Greg Matlashewski
PMC ID: PMC2629123 | DOI: 10.1371/journal.pntd.0000372 |ISSN: 1935-2727 | Journal: PLoS Neglected Tropical Diseases, 3(1)
Originaldocument: PMC | Score: 17.646307 | Text size: 42398 | Find: similardocuments
DataCollection, and Determination of Crystal Structure Five compounds (Fig. 2),purchased from ChemDiv (San Diego, California) were used for co-crystallizationwith the CYP51Mt C37L/C442A double mutant. ... structures and bindingaffinities of compounds. 1Compounds are identified by the numbers in the ChemDiv,Inc., product library catalog. 10.1371/journal.pntd.0000372.t001 Table 1Crystallographic data and statistics. Compound # Compound 8 Compound 9 Compound11 ChemDiv # 4596-0233 C155-0065 C155-0337 PDB ID 2W0B 2W092W0A Data collection Wavelength, Å 1.0000 1.0000
Golgicide A reveals essential roles for GBF1 in Golgi assembly andfunction
Jose B. Saenz; William J. Sun; Jae Won Chang; Jinmei Li; Badry Bursulaya; Nathanael S.Gray;David B. Haslam
PMC ID: PMC3500152 | DOI: 10.1038/nchembio.144 |ISSN: 1552-4450 | Journal: Nature chemical biology, 5(1) pp. 157-165 |Publicationdate: 2009-02-01 | Print publication date: 2009-03
Originaldocument: PMC | Score: 13.996932 | Text size: 47015 | Find: similar documents
characterizationof GCA GCA was identified from a commercial compound library availablefrom ChemDiv.
Glucose and GLP-1 Stimulate cAMP Production via Distinct AdenylylCyclases in INS-1E Insulinoma Cells
Lavoisier S.Ramos;Jonathan HaleZippin;Margarita Kamenetsky; Jochen Buck; Lonny R. Levin
PMC ID: PMC2518727 | DOI: 10.1085/jgp.200810044 |ISSN: 0022-1295 | Journal: The Journal of General Physiology, 132(1) pp. 329-338 |Publisher: The RockefellerUniversity Press | Publicationdate: 2008-09 | Print publication date: 2008-09
Originaldocument: PMC | Score: 14.117049 | Text size: 47594 | Find: similardocuments
KH7 wassynthesized by ChemDiv, Inc. or by the Milstein Chemical CoreFacility of Weill Medical College of Cornell University.
Anthony Arnoldo; Jasna Curak; SaranyaKittanakom;Igor Chevelev; Vincent T. Lee; MehdiSahebol-Amri; Becky Koscik; Lana Ljuma; Peter J. Roy;Antonio Bedalov; Guri Giaever; Corey Nislow; Rod A. Merrill; Stephen Lory; Igor Stagljar; Michael Snyder
PMC ID: PMC2265467 | DOI: 10.1371/journal.pgen.1000005 |ISSN: 1553-7390 | Journal: PLoS Genetics, 4(1) | Publisher: PublicLibrary of Science | Publicationdate: 2008-02-29 | Print publication date: 2008-02
Originaldocument: PMC | Score: 13.536236 | Text size: 68024 | Find: similardocuments
Sigma-Aldrich),the SPECTRUM library (2,000 compounds, MicroSource Discovery Inc.) and a ChemDiv library(53,000 compounds) were screened at a final concentration of 50 μM.
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transductionin human neutrophils
Hyunsil Han; AlexanderStessin;Julia Roberts; Kenneth Hess; Narinder Gautam; MargaritaKamenetsky;Olivia Lou; Edward Hyde; Noah Nathan;William A.Muller;Jochen Buck; Lonny R. Levin; Carl Nathan
PMC ID: PMC2213086 | DOI: 10.1084/jem.20050778 |ISSN: 0022-1007 | Journal: The Journal of Experimental Medicine, 202(1) pp.353-361 |Publisher: The Rockefeller University Press | Publicationdate: 2005-08-01 | Print publication date: 2005-08-01
Originaldocument: PMC | Score: 13.996932 | Text size: 46151 | Find: similardocuments
A collectionof 15,000 compounds with drug-like characteristics from ChemDiv Labswas screened robotically in the High Throughput Screening Facility at TheRockefeller
Discovery of Glycine Hydrazide Pore-occluding CFTR Inhibitors
ChatchaiMuanprasat;N.D. Sonawane; Danieli Salinas; AlessandroTaddei;Luis J.V.Galietta;A.S. Verkman
PMC ID: PMC2229623 | DOI: 10.1085/jgp.200409059 |ISSN: 0022-1295 | Journal: The Journal of General Physiology, 124(1) pp. 125-137 |Publisher: TheRockefeller University Press | Publicationdate: 2004-08 | Print publication date: 2004-08
Originaldocument: PMC | Score: 13.536236 | Text size: 54001 | Find: similardocuments
molecules(most 250–550 D) were selected for screening from commercial sources(ChemBridge andChemDiv) using algorithms designed to maximize chemicaldiversity and drug-like properties.
Structural model of nicotinic acetylcholine receptor isotypes bound toacetylcholine and nicotine
MatthieuSchapira;Ruben Abagyan; Maxim Totrov
PMC ID: PMC65631 | DOI: 10.1186/1472-6807-2-1 |Journal: BMC Structural Biology, 2(1) pp. 1-1 |Publisher: BioMed Central | Publicationdate: 2002-01-18
Originaldocument: PMC | Score: 17.77341 | Text size: 28361 | Find: similardocuments
be specificfor beta2-containing nAChR subtypes, we searched a database of over 200,000compounds (ChemDiv Inc., San Diego, CA), for alpha4-beta2 ligandcandidates presenting a functional group close to Ala 135 ... ligand wassimilar than the grid docking previously described [21]: each flexible ligandof the ChemDivpublic library (ChemDiv Inc., San Diego) wasdocked automatically into the combination of potential maps described above,and
Yu Wei; Mukuo Wang; Yang Li; Zhangyong Hong; Dongmei Li; Jianping Lin
DOI: 10.1016/j.ejmech.2019.111936 |ISSN: 1768-3254,0223-5234 | Journal: European journal of medicinal chemistry, 187 pp.111936-111936 | Publisher: EditionsScientifiques Elsevier | Publication date: 2019-12-04 | Printpublication date: 2019-12-04
Originaldocument: Medline | Score: 21.96154 | Text size: 2134 | Find: similardocuments
ChemDiv library(1,492,362 compounds).
Prateek Kumar; Kumar UditSaumya;Rajanish Giri
DOI: 10.1080/07391102.2019.1696231 |ISSN: 1538-0254,0739-1102 | Journal: Journal of biomolecular structure & dynamics, pp.1-17|Publisher: Taylor & Francis | Publicationdate: 2019-12-04 | Print publication date: 2019-12-04
Originaldocument: Medline | Score: 25.324753 | Text size: 1964 | Find: similardocuments
strategy, wehave designed this study where two libraries of peptidomimetic compounds(Asinex & ChemDiv) were first screened against our modeled MurAstructure and then validated through molecular dynamic simulations. From ourvirtual screening, top four compounds (ChemDiv: D675-0102, D675-0217;Asinex: BDE25373574, BDE 26717803) were selected based on their docking
Emmanuel Bresso; Diana Fernandez; Deisy X Amora; Philippe Noel; Anne-SophiePetitot;Maria-EugêniaLisei de Sa;Erika V SAlbuquerque;Etienne G J Danchin; Bernard Maigret; Natália FMartins
PMC ID: PMC6832152 | DOI: 10.3390/molecules24203798 |ISSN: 1420-3049,1420-3049 | Journal: Molecules (Basel, Switzerland), 24(20)
Originaldocument: Medline | Score: 22.316162 | Text size: 1604 | Find: similardocuments
selectedmolecules allowed the identification of an active compound, namely C260-2124,from the ChemDivprovider, which can serve as a starting point forfurther investigations.
Structural optimization on a virtual screening hit of smoothened receptor
Shiwei Song; Jinyi Jiang; Li Zhao; Qin Wang; Wenfeng Lu; Chaonan Zheng; Jie Zhang; Haikuo Ma; Sheng Tian; Jiyue Zheng; Lusong Luo; Youyong Li;Zeng-Jie Yang; Xiaohu Zhang
DOI: 10.1016/j.ejmech.2019.03.057 |ISSN: 1768-3254,0223-5234 | Journal: European journal of medicinal chemistry, 172 pp. 1-15 |Publisher: EditionsScientifiques Elsevier | Publicationdate: 2019-03-26 | Print publication date: 2019-06-15
Originaldocument: Medline | Score: 21.122412 | Text size: 2638 | Find: similardocuments
The mostpotent compound (ChemDiv ID C794-1677: 47 nM) showed comparable Hhsignaling inhibition to the marketed drug vismodegib (46
Yubing Si; David Xu; KhuchtumurBum-Erdene;Mona K Ghozayel; Baocheng Yang; Paul A Clemons; Samy O Meroueh
DOI: 10.1002/cmdc.201800537 |ISSN: 1860-7187,1860-7179 | Journal: ChemMedChem, 14(1) pp. 119-131 |Publisher: Wiley-VCH |Publication date: 2018-12-20 | Printpublication date: 2019-01-08
Originaldocument: Medline | Score: 20.804443 | Text size: 3341 | Find: similardocuments
ChemDiv), acollection of diversity-oriented synthesis (DOS) compounds that containsnatural-product-like
Identification of a novel c-Myc inhibitor with antitumor effects onmultiple myeloma cells
Ruosi Yao; Xiaoyang Sun; Yu Xie; Xiaoshen Sun; Yao Yao; Hujun Li; Zhenyu Li; Jian Gao; Kailin Xu
PMC ID: PMC6146296 | DOI: 10.1042/BSR20181027 |ISSN: 1573-4935,0144-8463 | Journal: Bioscience reports, 38(5) | Publisher: PortlandPress on behalf of the Biochemical Society | Publication date: 2018-09-19 | Print publication date: 2018-10-31
Originaldocument: Medline | Score: 21.285069 | Text size: 1980 | Find: similardocuments
ChemDiv compounddatabase by molecular docking-based, high-throughput virtual screening.
Wenfeng Lu; Dihua Zhang; Haikuo Ma; Sheng Tian; Jiyue Zheng; Qin Wang; Lusong Luo; Xiaohu Zhang
DOI: 10.1016/j.ejmech.2018.05.035 |ISSN: 1768-3254,0223-5234 | Journal: European journal of medicinal chemistry, 155 pp. 34-48 |Publisher: EditionsScientifiques Elsevier | Publicationdate: 2018-05-23 | Print publication date: 2018-07-15
Originaldocument: Medline | Score: 20.649023 | Text size: 3052 | Find: similardocuments
moleculardocking-based virtual screening was conducted to identify promising Smoantagonists fromChemDiv library.
Adversarial Threshold Neural Computer for Molecular de Novo Design
Evgeny Putin; Arip Asadulaev; QuentinVanhaelen;Yan Ivanenkov; Anastasia VAladinskaya;Alex Aliper; Alex Zhavoronkov
DOI: 10.1021/acs.molpharmaceut.7b01137 |ISSN: 1543-8392,1543-8384 | Journal: Molecular pharmaceutics, 15(10) pp. 4386-4397 |Publisher: AmericanChemical Society | Publicationdate: 2018-03-30 | Print publication date: 2018-10-01
Originaldocument: Medline | Score: 22.316162 | Text size: 2231 | Find: similardocuments
The SMILESrepresentations of 15K druglike molecules from the ChemDiv collectionwere used as a training data set. For the different functions, ATNC outperformsORGANIC.
Virtual Screening of Small Molecular Inhibitors against DprE1
Gang Zhang; Song Guo; Huaqing Cui; Jianguo Qi
PMC ID: PMC6017230 | DOI: 10.3390/molecules23030524 |ISSN: 1420-3049,1420-3049 | Journal: Molecules (Basel, Switzerland), 23(3)
Originaldocument: Medline | Score: 21.87464 | Text size: 1534 | Find: similardocuments
ChemDiv datasetthrough virtual screening based on pharmacophore and molecular docking.
Insun Park; Ashwini M Londhe; Ji Woong Lim; Beoung-Geon Park; Seo Yun Jung; Jae Yeol Lee; Sang Min Lim; Kyoung Tai No; Jiyoun Lee; Ae Nim Pae
DOI: 10.1007/s10822-017-0067-9 |ISSN: 1573-4951,0920-654X | Journal: Journal of computer-aided molecular design, 31(10) pp.929-941 |Publisher: Springer | Publicationdate: 2017-09-14 | Print publication date: 2017-10
Originaldocument: Medline | Score: 20.804443 | Text size: 2674 | Find: similardocuments
structure ofCypD-cyclosporine A (CsA) complex and performed virtual screening of ChemDiv database,which yielded forty-five potential hit compounds with novel scaffolds.
Insun Park; Yu Jin Hwang; TaeHun Kim; Ambily Nath InduViswanath;Ashwini M Londhe; Seo Yun Jung; Kyoung Mi Sim; Sun-Joon Min; Ji Eun Lee;Jihye Seong; Yun Kyung Kim; Kyoung Tai No; Hoon Ryu; Ae Nim Pae
DOI: 10.1007/s10822-017-0052-3 |ISSN: 1573-4951,0920-654X | Journal: Journal of computer-aided molecular design, 31(10) pp.877-889 |Publisher: Springer | Publicationdate: 2017-09-06 | Print publication date: 2017-10
Originaldocument: Medline | Score: 21.122412 | Text size: 2508 | Find: similardocuments
pharmacophoremodel was built and employed for the virtual screening of ChemDiv andAsinex database.
Fusion of Structure and Ligand Based Methods for Identification of NovelCDK2 Inhibitors
Priya Mahajan; Gousia Chashoo; Monika Gupta; Amit Kumar; Parvinder PalSingh;Amit Nargotra
DOI: 10.1021/acs.jcim.7b00293 |ISSN: 1549-960X,1549-9596 | Journal: Journal of chemical information and modeling, 57(8)pp. 1957-1969 |Publisher: American Chemical Society | Publicationdate: 2017-08-03 | Print publication date: 2017-08-28
Originaldocument: Medline | Score: 21.533804 | Text size: 2024 | Find: similardocuments
A druglikelibrary of 50,000 compounds from ChemDiv and ChemBridgedatabases was screened against CDK2, and 110 compounds were identified usingthe
Ying Fu; Yi-Na Sun; Ke-Han Yi; Ming-Qiang Li; Hai-Feng Cao; Jia-Zhong Li; Fei Ye
PMC ID: PMC6152767 | DOI: 10.3390/molecules22060959 |ISSN: 1420-3049,1420-3049 | Journal: Molecules (Basel, Switzerland), 22(6)
Originaldocument: Medline | Score: 25.209267 | Text size: 2228 | Find: similardocuments
ChemDiv databasewas screened using CBP-Hypo2 as a 3D query, and the best-fit hits subjected tomolecular ... Keywords ChemDiv HPPD inhibitors HipHop modelmolecule docking pharmacophore model virtual screening MeSH
Identification of Novel Small-Molecule ASGP-R Ligands
Alexander GMajouga;Yan A Ivanenkov; Mark S Veselov; Anton V Lopuhov; Svetlana VMaklakova;Elena KBeloglazkina; Petr V Binevski; Natalya LKlyachko;Yuri BSandulenko;Natalia YGalkina;Victor EKoteliansky
DOI: 10.2174/1567201813666160719144651 |ISSN: 1875-5704,1567-2018 | Journal: Current drug delivery, 13(8) pp. 1303-1312 |Publisher:BenthamScience Publishers | Publicationdate: 2016 | Print publication date: 2016
Originaldocument: Medline | Score: 22.13743 | Text size: 1513 | Find: similardocuments
ChemDiv collectionand compounds provided by our colleagues to reveal potential ASGP-R binders.
Rukmankesh Mehra; Reena Chib; GurunadhamMunagala;Kushalava ReddyYempalla;Inshad Ali Khan; Parvinder PalSingh;Farrah Gul Khan; Amit Nargotra
DOI: 10.1007/s11030-015-9624-0 |ISSN: 1573-501X,1381-1991 | Journal: Molecular diversity, 19(4) pp. 1003-19 |Publisher: ESCOM Science Publishers | Publicationdate: 2015-08-01 | Print publication date: 2015-11
Originaldocument: Medline | Score: 21.702883 | Text size: 2179 | Find: similardocuments
ChemDiv (30,000compounds) databases.
Rukmankesh Mehra; Rashmi Sharma; Inshad Ali Khan; Amit Nargotra
DOI: 10.1016/j.ejmech.2014.12.030 |ISSN: 1768-3254,0223-5234 | Journal: European journal of medicinal chemistry, 92 pp. 78-90 |Publisher: EditionsScientifiques Elsevier | Publicationdate: 2014-12-18 | Print publication date: 2015-03-06
Originaldocument: Medline | Score: 21.367338 | Text size: 2185 | Find: similardocuments
ChemDiv databases.
Cheng-Hao Jin; Kyu-Yeon Jun; Eunjung Lee; Seongrak Kim; Youngjoo Kwon; Kunhong Kim; Younghwa Na
DOI: 10.1016/j.bmc.2014.07.037 |ISSN: 1464-3391,0968-0896 | Journal: Bioorganic & medicinal chemistry, 22(17) pp.4553-65 | Publisher:Elsevier Science | Publication date: 2014-07-30 | Print publication date: 2014-09-01
Originaldocument: Medline | Score: 21.122412 | Text size: 3074 | Find: similardocuments
ChemDiv chemicallibraries (2000: randomly selected; 2000: kinase-biased) and performed in vitrokinase
Deepak Bhattarai; MuhammadMuddassar;Jae Wan Jang; Seung Kon Hong; Eunice EunkyeongKim;Taegwon Oh; Sang-Nae Cho; Ae Nim Pae;Gyochang Keum
DOI: 10.2174/1573409911666150414150300 |ISSN: 1875-6697,1573-4099 | Journal: Current computer-aided drug design, 10(4) pp. 383-92 |Publisher: BenthamScience Publishers | Publicationdate: 2014 | Print publication date: 2014
Originaldocument: Medline | Score: 21.533804 | Text size: 2250 | Find: similardocuments
ChemDiv database.
AnuseemaBhadauriya;Gaurao V Dhoke; Rahul P Gangwal; Mangesh V Damre; Abhay TSangamwar
DOI: 10.1007/s11030-013-9425-2 |ISSN: 1573-501X,1381-1991 | Journal: Molecular diversity, 17(1) pp. 139-49 |Publisher: ESCOM Science Publishers | Publicationdate: 2013-01-19 | Print publication date: 2013-02
Originaldocument: Medline | Score: 22.005249 | Text size: 1746 | Find: similardocuments
pharmacophoremodels were used to screen several small-molecule databases, including Specs,NCI,ChemDiv and Natural product databases to identify the potentialdual ACC inhibitors.
Targeting the transposase domain of the DNA repair component Metnase toenhance chemotherapy
Elizabeth AWilliamson;Leah Damiani; Andrei Leitao; Chelin Hu; Helen Hathaway; Tudor Oprea; Larry Sklar; Montaser Shaheen; Julie Bauman; Wei Wang; Jac A Nickoloff; Suk-Hee Lee; Robert Hromas
PMC ID: PMC3972061 | DOI: 10.1158/0008-5472.CAN-12-0313 |ISSN: 1538-7445,0008-5472 | Journal: Cancer research, 72(23) pp. 6200-8 |Publisher: AmericanAssociation for Cancer Research | Publicationdate: 2012-10-22 | Print publication date: 2012-12-01
Originaldocument: Medline | Score: 20.804443 | Text size: 2425 | Find: similardocuments
ChemDiv libraryto identify small molecules that might dock in the active site of thetransposase nuclease
Application of validated QSAR models of D1 dopaminergic antagonists fordatabase mining
Scott Oloff; Richard BMailman;AlexanderTropsha
DOI: 10.1021/jm049116m |ISSN: 0022-2623,0022-2623 | Journal: Journal of medicinal chemistry, 48(23) pp. 7322-32 |Publisher: American Chemical Society | Publicationdate: 2005-11-17 | Print publication date: 2005-11-17
Originaldocument: Medline | Score: 22.093195 | Text size: 2350 | Find: similardocuments
(NCI)database of ca. 250,000 compounds, the Maybridge Database of ca. 56,000compounds, and theChemDiv Database of ca. 450,000 compounds. These searchesresulted in only 54 consensus hits (i.
Kinase inhibitor recognition by use of a multivariable QSAR model
D G Sprous; John Zhang; Lei Zhang; Zhaolin Wang; M A Tepper
DOI: 10.1016/j.jmgm.2005.09.004 |ISSN: 1093-3263,1093-3263 | Journal: Journal of molecular graphics & modelling, 24(4)pp. 278-95 |Publisher: Elsevier Science, Inc. | Publicationdate: 2005-10-25 | Print publication date: 2006-01
Originaldocument: Medline | Score: 22.316162 | Text size: 2265 | Find: similardocuments
We appliedthis model to evaluate the commercial kinase libraries available from Asinex,BioFocus, ChemDivand LifeChemicals to facilitate purchase decisionsfor compounds for HTS for lead compounds.
SOLUBLE CD33 FOR TREATING MYELODYSPLASTIC SYNDROMES (MDS)
LIST, Alan F.[US];WEI, Sheng [US]
Publicationdate: 2020-01-08 | Patent publication No.: EP-3016512-B1|Assignees: H. Lee Moffitt Cancer Center And Research Institute, Inc. [US] | IPC: A01N25/00;A61K39/00; C12P21/04 | Oldestpriority date: 2014-04-10 | Publication date: 2020-01-08
Score: 11.569273 | Text size: 173774 | Find: similardocuments
ChemBridgeCorporation (16981 Via Tazon, Suite G, San Diego, CA, 92127, USA, www.chembridge.com);ChemDiv (6605Nancy Ridge Drive, San Diego, CA 92121, USA); Life Chemicals (1103 OrangeCenter Road,
METHOD TO DETECT ACTIVITY OF A POLYMERASE
BERGBREDE, Tim[DE];LARSSON,Nils-Göran [DE]; GUSTAFSSON,Claes [SE];FALKENBERG-GUSTAFSSON,Maria [SE]
Publicationdate: 2020-01-08 | Patent publication No.: EP-3303613-B1|Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. [DE];Lead Discovery Center GmbH [DE] | IPC: C12Q1/68 | Oldestpriority date: 2015-05-29 | Publication date: 2020-01-08
Score: 13.327991 | Text size: 122895 | Find: similardocuments
in the assaywas 4-methyl-5-[2-(pyrimidin-2-ylamino)thiazol-4yl]thiazol-2-amine (availableat ChemDiv) and is applied using contact-free acousticdroplet-dispensing (Labcyte Echo®) from 10 mM compound
COMPOSITIONS AND METHODS FOR INHIBITION OF AUTOPHAGY
Elizabeth J.Goldsmith [US]; Alexander T.Piala [US];Malia B. Potts[US]
Publicationdate: 2020-01-02 | Patent publication No.: US-20200000806-A1|Assignees: Board of Regents, The University of Texas System [US] | IPC: A61K31/517;A61K31/427; A61K31/428 | Oldestpriority date: 2016-05-26 | Publication date: 2020-01-02
Score: 14.293713 | Text size: 60848 | Find: similardocuments
These 13compounds were purchased from Chembridge Inc. and ChemDiv Inc. formeasurement of direct binding using Differential Scanning Fluorimetry (DSF).
INHIBITORS OF HIV-1 INTEGRASE MULTIMERIZATION
Mark D. ANDRAKE[US];Anna MarieSKALKA [US];George W. Merkel[US]
Publicationdate: 2019-12-19 | Patent publication No.: US-20190381054-A1|Assignees: Institute for Cancer Research d/b/a The Research Institute of Fox ChaseCancer Center [US] | IPC: A61K31/53; A61K31/4245; A61K31/454 | Oldest priority date: 2017-01-26 | Publication date: 2019-12-19
Score: 17.30191 | Text size: 55022 | Find: similardocuments
formation(see FIG. 1B), and used it to screen the 50,000 compound chemical diversitylibrary of ChemDiv, ltd. at 10 uM concentration. ... day wereperformed to screen the entire Chemical Diversity set of 50,000 compoundsobtained from ChemDiv, Ltd.
METHODS FOR TREATMENT OF RETINAL DISEASE BY PHOTORECEPTOR GENE EXPRESSIONMODULATION
Thomas A. Reh[US];Paul Nakamura[US];Sheng Ding [US]
Publicationdate: 2019-12-19 | Patent publication No.: US-20190381047-A1|Assignees: University of Washington [US]; The J. David Gladstone Institutes, aTestamentary Trust Established Under the Will of J. David Glads [US] | IPC: A61K31/519;C07D495/04; A61K31/426; A61K9/00; A61P27/02 | Oldest priority date: 2015-03-27 | Publication date: 2019-12-19
Score: 18.390413 | Text size: 53739 | Find: similar documents
(I) isCA8801: [[image:EMI-C00006]] Compounds CA88 and CA8801 are commerciallyavailable from ChemDiv(San Diego, Calif. ... (II) is CA9513:[[image:EMI-C00010]] Compounds CA95 and CA9513 are commercially availablefrom ChemDiv (San Diego, Calif. ... Nr2e3 interactingmolecules specifically identified herein were obtained commercially from ChemDiv (SanDiego, Calif.
Osteocalcin as a treatment for cognitive disorders
Gerard Karsenity[US];Franck Oury [US]
Publicationdate: 2019-12-19 | Patent publication No.: US-20190381142-A1|Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | IPC: A61K38/22;G01N33/68 | Oldestpriority date: 2013-03-15 | Publication date: 2019-12-19
Score: 10.089907 | Text size: 305978 | Find: similardocuments
MaybridgeHitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352compounds);ChemDiv Combilab and International (28,864 compounds);Mixed Commercial Plate 1 (352 compounds); Mixed
TACHDJIAN,Catherine [US]; WALLACE, David[US];LEBL-RINNOVA,Marketa [US]
Publicationdate: 2019-12-18 | Patent publication No.: EP-1850681-B1|Assignees: Firmenich Incorporated [US] | IPC: A23L27/20; A23L27/26; A23L2/56; A23L23/00; A23L2/02; A61K31/395;C07D401/12; C07D401/14 | Oldestpriority date: 2005-02-04 | Publication date:2019-12-18
Score: 11.239684 | Text size: 190835 | Find: similardocuments
other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, PA, ChemDiv of San Diego, CA, Chembridge of SanDiego, CA, Asinex of Moscow, Russia, SPECS/BIOSPECS of the
Inhibitors of RAD52 Recombination Protein and Methods Using Same
Publicationdate: 2019-12-12 | Patent publication No.: US-20190375761-A1|Assignees: DREXEL UNIVERSITY [US] | IPC: C07D495/04; C07D491/056; C07D307/82; A61K45/06; A61K31/55; A61K31/5377;A61K31/517; A61K31/496; A61K31/4741; A61K31/4525; A61P35/00; C07D471/04;C07D239/95; C07D405/12; C07D215/38 | Oldestpriority date: 2015-06-04 | Publication date: 2019-12-12
Score: 12.484504 | Text size: 132719 | Find: similardocuments
Thecompounds for confirmation analysis were purchased from Asinex Ltd., ChemBridgeCo., ChemDiv Inc, Enamine, FCH Group, Frontier Scientific ServicesInc., InterBioScreen Ltd., Life Chemicals Inc.
MASP-2 INHIBITORS AND METHODS OF USE
Neil S. Cutshall[US];Jennifer LynnGage [US];Franz A.Gruswitz [US]; Juhienah Khalaf[US];Thomas L. Little[US];Markus Metz [US]; Jeremiah H.Nguyen [US];Peter KurtNollert von Specht [US]; Jennifer Tsoung[US];MichaelCicirelli [US]; Sara RebeccaGoldstein [US]; Santosh KumarKeshipeddy [US]; Do Yeon Kwon[US];Robert HuertaLemus [US];Sudheer BabuVaddela [US]
Publicationdate: 2019-12-05 | Patent publication No.: US-20190367452-A1|Assignees: Omeros Corporation [US] | IPC: C07D205/04; C07D211/60; C07D401/12; C07D217/14; C07C251/24; C07D213/73;C07D239/94; C07D235/30; C07D207/24; C07D295/135; C07C235/88; C07D295/033;C07D257/04; C07D207/16; C07D207/36; C07D295/26; C07D213/81; C07D417/12;C07D277/56; C07D231/44; C07D471/04; C07D233/64; C07D403/12; C07D249/08;C07D401/14; C07D417/14; C07D471/06; C07D413/12; C07D409/14; C07D495/04;C07D409/10; C07D413/14; C07D401/06; C07D403/06; C07D239/96 | Oldest priority date: 2018-05-29 | Publication date: 2019-12-05
Score: 8.340613 | Text size: 1173407 | Find: similardocuments
In certainaspects, a ChemDiv library (12760 High Bluff Drive, Suite 370,San Diego, Calif. 92130 USA) is used. The ChemDiv libraryoffers a wide variety of compounds including more than 1.5 M individual solidscreening
MASP-2 INHIBITORS AND METHODS OF USE
METZ, Markus[US];GOLDSTEIN, SaraRebecca [US]; KESHIPEDDY,Santosh Kumar [US]; KWON, Do Yeon[US];LEMUS, RobertHuerta [US];VADDELA, SudheerBabu [US];CUTSHALL, NeilS. [US];GAGE, JenniferLynn [US];GRUSWITZ, FranzA. [US];KHALAF, Juhienah[US];LITTLE, ThomasL. [US];NGUYEN, JeremiahH. [US];NOLLERT VONSPECHT, Peter Kurt [US]; TSOUNG, Jennifer[US];CICIRELLI,Michael [US]; METZ, Markus[US];GOLDSTEIN, SaraRebecca [US]; KESHIPEDDY,Santosh Kumar [US]; KWON, Do Yeon[US];LEMUS, RobertHuerta [US];VADDELA, SudheerBabu [US]
Publicationdate: 2019-12-05 | Patent publication No.: WO-2019231933-A2|Assignees: OMEROS CORPORATION [US] | IPC: C07D205/04 |Oldest priority date: 2018-05-29 | Publicationdate: 2019-12-05
Score: 8.340613 | Text size: 1086216 | Find: similardocuments
is a publicaccess service for structure-based ligand discovery. [0203] In certain aspects,a ChemDiv library (12760 High Bluff Drive, Suite 370, SanDiego, CA 92130 USA) is used. The ChemDiv library offers awide variety of compounds including more than 1.5 M individual solid screening
HOUSEY, Gerard,M. [US];BALASH, Monica,E. [US];HOUSEY, Gerard,M. [US]
Publicationdate: 2019-11-21 | Patent publication No.: WO-2019222690-A1|Assignees: HMI, INC. [—] | IPC: C07K16/22; A61K38/00 |Oldest priority date: 2018-05-17 | Publicationdate: 2019-11-21
Score: 12.290053 | Text size: 157205 | Find: similardocuments
and includeAMRI library, AnalytiCon, BioFocus DPI Library, Chem-XInfmity, ChemBridgeLibrary, ChemDivLibrary, Enamine Library, The Greenpharma NaturalCompound Library, Life Chemicals Library,
HIGH PRECISION SPECTRAL FRET ASSAYS
Tory M. Schaaf[US];David D. Thomas[US];Benjamin Grant[US];Kurt C. Peterson[US];Gregory D.Gillispie [US]
Publicationdate: 2019-11-21 | Patent publication No.: US-20190353663-A9|Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA [US] | IPC: G01N33/68;G01N33/52; G01N33/542; G01N33/58 | Oldestpriority date: 2017-01-25 | Publication date: 2019-11-21
Score: 11.918776 | Text size: 202839 | Find: similardocuments
and includeAMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridgeLibrary, ChemDivLibrary, Enamine Library, The Greenpharma NaturalCompound Library, Life Chemicals Library,
Flavivirus protease inhibitors
RadhakrishnanPadmanabhan [US]; TadahisaTeramoto [US]; Mark Manzano[US]
Publicationdate: 2019-11-12 | Patent publication No.: US-10471082-B2|Assignees: Georgetown University [US] | IPC: A61K31/7032; A61K31/519; A61K31/12; A61K31/352; A61K31/415; A61K31/426;A61K31/44; A61K31/7034; A61K31/4178; A61K45/06 | Oldest priority date:2012-10-23 | Publication date: 2019-11-12
Score: 14.971729 | Text size: 52283 | Find: similardocuments
from, forexample, Alfa Aesar (Ward Hill, Mass.); ChemBridge Corporation (San Diego,Calif.); ChemDiv (San Diego, Calif.); and WaterstoneTechnology (Carmel, Ind.). IV.
FERROCHELATASE INHIBITORS AND METHODS OF USE
CORSON, TimothyW. [US];SEO, Seung-Yong[KR];LEE, Bit [KR]
Publicationdate: 2019-11-07 | Patent publication No.: WO-2019213076-A1|Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US]; GACHONUNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR] | IPC: A61K31/522;C07D487/04 | Oldestpriority date: 2018-04-30 | Publication date: 2019-11-07
Score: 16.068731 | Text size: 145281 | Find: similardocuments
at theIndiana University School of Medicine Chemical Genomics Core Facility (CGCF)using the ChemDiv 10K and a portion (10,000 compounds) of theChemBridge 50K libraries of chemical compounds. ... IC50 determinationCompounds, reordered from ChemDiv or synthesized as describedabove, were made to 10 mM in DMSO and tested in the FECH enzymatic
SLC26A3 INHIBITORS AND USE THEREOF
VERKMAN, Alan S.[US];CIL, Onur [US]; HAGGIE, Peter M.[US]
Publicationdate: 2019-10-31 | Patent publication No.: WO-2019210103-A2|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/37;A61K31/4164; A61K31/472; A61P1/10; C07D311/42 | Oldest priority date: 2018-04-25 | Publication date: 2019-10-31
Score: 17.506392 | Text size: 107835 | Find: similardocuments
Initialscreening was done of -50,000 drug-like synthetic small molecules (ChemDiv,San Diego, CA) at a concentration of 25 mM using a Cl /T exchange protocol toassay slc26a3 function. Following initial screening, compound analogs werepurchased (ChemDiv, San Diego, CA) to generate structure-activity data.... After initial screening, analogs of active compounds were purchased (ChemDiv)to generate structure-activity relationship data.
FOLEY, Megan[US];TAIT, Bradley[US];CULLEN, Matthew[US]
Publicationdate: 2019-10-16 | Patent publication No.: EP-3552664-A1|Assignees: Proteostasis Therapeutics, Inc. [US] | IPC: A61P25/28 |Oldestpriority date: 2011-05-12 | Publication date: 2019-10-16
Score: 10.354719 | Text size: 282678 | Find: similar documents
Compound A47(also shown below) was purchased from ChemDiv, San Diego, CA.
Inhibitors of RAD52 recombination protein and methods using same
Publicationdate: 2019-10-15 | Patent publication No.: US-10442817-B2|Assignees: Drexel University [US] | IPC: C07D215/38; C07D405/12; C07D239/95; C07D471/04; C07D495/04; A61K31/517;A61K31/496; A61K31/55; A61K31/47; A61K45/06; A61P35/00; C07D491/048;A61K31/4525; A61K31/4741; A61K31/5377; C07D307/82; C07D491/056; A61K31/4188 | Oldest priority date: 2015-06-04 | Publication date:2019-10-15
Score: 12.484504 | Text size: 136518 | Find: similardocuments
Thecompounds for confirmation analysis were purchased from Asinex Ltd., ChemBridgeCo., ChemDiv Inc, Enamine, FCH Group, Frontier Scientific ServicesInc., InterBioScreen Ltd., Life Chemicals Inc.
NOVEL ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE
Bonnie L.Bassler [US]; Nina M.Hoyland-Kroghsbo [DK]; Jon E.Paczkowski [US]
Publicationdate: 2019-10-10 | Patent publication No.: US-20190307818-A1|Assignees: The Trustees of Princeton University [US] | IPC:A61K35/76; A61K45/06; A61P31/04; A01N63/00; G01N33/68; A61K31/353;A61K31/12; A61K31/44; A61K31/381; A61K31/365; A23L3/3454 |Oldest prioritydate: 2016-04-08 | Publication date: 2019-10-10
Score: 14.450268 | Text size: 180781 | Find: similardocuments
made to 10mM and stored at −20° C.. lab Princeton Chemistry Department Various(TCI, ChemBridge,ChemDiv, Cayman Chemicals, Santa Cruz Chemicals, ALFAAESA) Arabinose inducer 10% w/v in H2O (autoclaved, ... Princeton ChemistryDepartment Various (TCI, ChemBridge, ChemDiv, Cayman Chemicals,Santa Cruz Cehmicals, ALFA AESA) Arabinose inducer stock 10% w/v in H2O
TRPC4 INHIBITORS AND USES THEREOF
CRAWFORD, John,Stuart [US];OSTERTAG, Eric[US]
Publicationdate: 2019-10-09 | Patent publication No.: EP-2467398-B1|Assignees: Poseida Therapeutics, Inc. [US] | IPC: A61K31/18; C07K14/705; A61P25/04; C12N15/113 | Oldest priority date: 2009-10-01 | Publication date: 2019-10-09
Score: 12.290053 | Text size: 124973 | Find: similardocuments
It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigrna-Aldrich (St.Louis, Mo.
GLUN2C/D SUBUNIT SELECTIVE ANTAGONISTS OF THE N-METHYL-D-ASPARTATERECEPTOR
LIOTTA, DennisC. [US];TRAYNELIS,Stephen F. [US]; JING, Yao [US]
Publicationdate: 2019-10-03 | Patent publication No.: WO-2019191424-A1|Assignees: EMORY UNIVERSITY [US] | IPC: A61K31/135; A61K31/451; A61K31/662 | Oldest priority date: 2018-03-28 | Publication date: 2019-10-03
Score: 13.10661 | Text size: 133326 | Find: similardocuments
lT7-pyrazol-l-yl)-4-oxobutanoicacid (DQP-1105) was selected from a Ca2+-based screen of ChemDiv andAsinex diversity libraries as GluN2C/D-selective antagonists [75,76] andexhibited inhibition
Methods of treating muscular dystrophy
Dean Burkin [US]; Ryan Wuebbles[US]
Publicationdate: 2019-09-03 | Patent publication No.: US-10398749-B2|Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THEUNIVERSITY OF NEVADA, RENO [US] | IPC: A61K38/05; A61K31/496; A61K31/4985; A61K31/506; A61K38/39; A61K31/5375;A61K31/343; A61K31/4418; A61K31/444; A61K31/4709; A61K31/53; A61K45/06;A61K31/5377; A61K31/5383; A61K31/551; A61K31/57; A61K31/661; A61K31/16;A61K31/575; A61K31/5365; A61K31/4178; A61K31/20; A61K31/519; A61K31/541;A61K31/19; A61K31/277; A61K31/341; A61K31/36; A61K31/37; A61K31/381;A61K31/4025; A61K31/4035; A61K31/41; A61K31/415; A61K31/4196; A61K31/421;A61K31/426; A61K31/4365; A61K31/4402; A61K31/47; A61K31/473; A61K31/498;A61K31/404; A61K31/4164; A61P21/00 | Oldestpriority date: 2012-09-10 | Publication date: 2019-09-03
Score: 14.190399 | Text size: 216957 | Find: similardocuments
Heidelberg);the DIVERSet library (Chembridge Corp., San Diego, Calif.) and compounds fromthe ChemDivlibrary. ... to activate expression of the α7 integrinCompound (Obtained Commercially from ChemDiv Library)[[image:EMI-C00026]] [[image:EMI-C00027]] 1080-0573 5α-cholestan-3β- 20
USE OF ALDEHYDE DEHYDROGENASE AS BIOMARKER FOR BETA-CELL DYSFUNCTION ANDLOSS
Domenico Accili[US];Ja YoungKim-Muller [US]
Publicationdate: 2019-08-29 | Patent publication No.: US-20190265229-A1|Assignees: The Trustees of Columbia University in the City of New York [US] | IPC: G01N33/50 | Oldest priority date: 2015-09-15 | Publication date: 2019-08-29
Score: 11.569273 | Text size: 251540 | Find: similardocuments
MaybridgeHitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352compounds);ChemDiv Combilab and International (28,864 compounds);Mixed Commercial Plate 1 (352 compounds); Mixed
Methods and compositions to treat cancer
Jeffrey Whitsett[US];Yutaka Maeda[US]
Publicationdate: 2019-08-27 | Patent publication No.: US-10391084-B2|Assignees: Children's Hospital Medical Center [US] | IPC:A61K31/429; A61P35/00 | Oldestpriority date: 2013-06-20 | Publication date: 2019-08-27
Score: 14.039395 | Text size: 70642 | Find: similardocuments
3-[2-(4-fluorobenzyl)imidazo[2,1-beta][1,3]thiazol-6-yl]-2H-chromen-2-one(iMDK) purchased from ChemDiv(San Diego, Calif.) was dissolved inDMSO.
TACHDJIAN,Catherine [US]; TANG, Xiao-Qing[US];KARANEWSKY,Donald, S. [US]; SERVANT, Guy[US];LI, Xiaodong[US];ZHANG, Feng [US]; CHEN, Qing [US]; ZHANG, Hong [US]; DAVIS, Timothy[US];DARMOHUSODO,Vincent [US]; WONG, Melissa[US];SELCHAU, Victor[US]
Publicationdate: 2019-08-21 | Patent publication No.: EP-2552207-B1|Assignees: Firmenich Incorporated [US] | IPC: A61K31/47; A23L27/20; C07D215/54 | Oldestpriority date: 2010-04-02 | Publication date: 2019-08-21
Score: 10.089907 | Text size: 294647 | Find: similardocuments
other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, PA, ChemDiv of San Diego, CA, Chembridge of SanDiego, CA, Asinex of Moscow, Russia, SPECS/BIOSPECS of the
TRAN, Nhan [US]; MEURICE,Nathalie [US]; DHRUV, Harshil[US];YIN, Hongwei[US]
Publicationdate: 2019-08-21 | Patent publication No.: EP-3019874-B1|Assignees: The Translational Genomics Research Institute [US] |IPC: G01N33/68; A61K31/53; A61K31/542; A61K31/4704; A61K31/541; A61K31/4188;A61K31/4192; A61K31/24; A61K45/06; A61K31/4745; A61K33/24 | Oldest priority date: 2013-09-20 | Publication date: 2019-08-21
Score: 18.245615 | Text size: 196068 | Find: similardocuments
implementedto identify virtual hits from a vendor compound library of peptidomimeticmolecules (ChemDiv, 13,637 compounds). ... The peptidomimetic setof ChemDiv (version of May 2011; 13,137 compounds) wasprepared using LigPrep version 2.5 in Schrodinger v2011 ... The peptidomimeticset of ChemDiv (13,137 compounds, v05.2011) was selected forthis study and pre-processed as described in methods. ... As shown in Figure10A, 4 compounds from the supplier ChemDiv with compoundidentifiers G873-0032, F151-0435, D715-0890, and J004-1091 showed an average... These core substructures served as query to perform a substructure searchin the ChemDiv online catalogue.
FIBROSIS INHIBITING COMPOUNDS FOR USE IN THE PREVENTION OR TREATMENT OFFIBROSING DISEASES
GOMER, Richard,H. [US];COX, Nehemiah[US]
Publicationdate: 2019-08-21 | Patent publication No.: EP-3065548-B1|Assignees: THE TEXAS A&M UNIVERSITY SYSTEM [US] | IPC:A01N43/00; A61K31/33; A61K31/41; A61K31/425; A61K31/38; A01N37/18;A61K31/16; A61P11/06; A61P11/00; A61P1/16; A61P1/00; A61P9/00; A61P13/12;A61P17/00; A61P19/00; A61P43/00 | Oldestpriority date: 2013-09-30 | Publication date: 2019-08-21
Score: 14.165414 | Text size: 61824 | Find: similardocuments
Compound 2(Cat#545-1519) and compound 3 (Cat#4545-1530) were purchased from ChemDiv (SanDiego, CA).
MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE
SCHNEEKLOTH,John, Jr. [US]; SIMMONS, John[US];FELSENSTEIN,Kenneth [US]; MOCK, Beverly[US];SAUNDERS,Lindsey [US]; GAREISS, Peter[US];CALABRESE, David[US];LEON, Elena [US]
Publicationdate: 2019-08-21 | Patent publication No.: EP-3242661-B1|Assignees: The U.S.A. as represented by the Secretary, Department of Health and HumanServices [US]; Yale University [US] | IPC: C07D307/84; A61K31/343; A61P35/00 | Oldest priority date: 2015-01-05 | Publication date: 2019-08-21
Score: 18.078405 | Text size: 187023 | Find: similardocuments
20,000unique small molecule stock solutions (10 mM in DMSO) purchased from ChemBridgeand ChemDivscreening libraries, in addition to dyes and controls,were printed in duplicate onto four slides ... No.Peggy (% c-Myc expressioncompared to untreated)IC50 1 [[image:ib0037]] Commercial: ChemDiv No.D089-0563 50% (at 10 μM) 7.6 μM 2[[image:ib0038]] Commercial: ChemDiv No. D089-0474 72% (at 10 μM) 95%viability (at 10 μM) 3[[image:ib0039]] Commercial: Otava Chemical No. 7018860541 52% (at 10 μM) 6.3 μM 4[[image:ib0040]] Commercial: ChemDiv No. D089-0559 73% (at 10 μM) 75%viability (at 10 μM) 5[[image:ib0041]] Commercial: ChemBridge No.
Methods for use in combination for the treatment and diagnosis ofautoimmune diseases
Hakon Hakonarson[US];Yun Rose Li [US]; Brendan Keating[US]
Publicationdate: 2019-08-20 | Patent publication No.: US-10385398-B2|Assignees: The Children's Hospital of Philadelphia [US] | IPC:C12Q1/68; C12Q1/6883 | Oldestpriority date: 2015-08-21 | Publication date: 2019-08-20
Score: 9.370946 | Text size: 364358 | Find: similardocuments
Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.
Methods and Compositions for Re-activating Epstein-Barr Virus andScreening Compounds Therefor
Paul M.Lieberman [US]; NadezhdaTikhmyanova-Eckert [US]; Joseph M.Salvino [US]
Publicationdate: 2019-08-08 | Patent publication No.: US-20190240202-A1|Assignees: The Wistar Institute of Anatomy and Biology [US]; Drexel University [US] | IPC: A61K31/437;C12Q1/02; A61K45/06; A61K31/19; A61K31/69; A61K31/522; C07D471/04 | Oldest priority date:2013-08-31 | Publication date: 2019-08-08
Score: 19.037996 | Text size: 98277 | Find: similardocuments
FIG. 2B is ascatter plot of luminescence values for HTS campaign of the ChemDiv library.The well number is indicated on the X-axis. FIG. 2C is a scatter plot of datafrom HTS of ChemDiv screen (FIG. 2B) re-sorted according tothe fold induction of luminescence relative to DMSO. FIG. ... clinicalcollection, a 14,400 compound library from Maybridge, and a 50,000 compoundlibrary from ChemDiv. The Maybridge “Hit Finder” library representslead-like diversity from the larger Maybridge screening collection (56,000).The ChemDivlibrary consists of a 30,000 compound “DiscoveryChemistry” set of diverse lead-like small
Guy SERVANT [US]; Hong Chang [US]; Cyril REDCROW[US];Sumita Ray [US]; lmran CLARK [US]; Bryan MOYER [US]
Publicationdate: 2019-08-08 | Patent publication No.: US-20190242905-A1|Assignees: SENOMYX, INC. [US] | IPC: G01N33/68; G01N33/50; C12Q1/02; C12N15/85 | Oldest priority date: 2001-05-01 | Publication date: 2019-08-08
Score: 12.484504 | Text size: 152301 | Find: similardocuments
It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.
METHODS OF TREATING MUSCULAR DYSTROPHY
Dean Burkin [US]; Ryan Wuebbles[US]
Publicationdate: 2019-08-08 | Patent publication No.: US-20190240195-A1|Assignees: Board of Regents of the Nevada System of Higher Education, on Behalf of theUniv of Nevada, Reno [US] | IPC: A61K31/404; A61K45/06 | Oldestpriority date: 2013-03-15 | Publication date:2019-08-08
Score: 10.089907 | Text size: 347299 | Find: similardocuments
et al.,2006). 2) DIVERSet library (Chembridge Corp., San Diego, Calif.) and compoundsfrom the ChemDivlibrary. 3) LOPAC library (Sigma-RPI) consists of1280 pharmaceutically active compounds.
COMPOSITIONS AND METHODS FOR INHIBITING GROUP II INTRON RNA
PYLE, Anna [US]; FEDOROVA, Olga[US];JAGDMANN, Erik,Gunnar [US];VAN ZANDT,Michael [US]; YUAN, Lin [US]; DeBERARDINIS,Albert [US]
Publicationdate: 2019-08-01 | Patent publication No.: WO-2019147894-A1|Assignees: YALE UNIVERSITY [US] | IPC: A61K35/12; C12N15/113; C12N9/22 | Oldestpriority date: 2018-01-26 | Publication date: 2019-08-01
Score: 10.089907 | Text size: 282266 | Find: similardocuments
(76compounds), protease inhibitors (53 compounds) and additional compounds fromChemBridge MW andChemDiv to bring the total number of compounds to10000. The D135 ribozyme (Su et al.
Methods for treatment of retinal disease by photoreceptor gene expressionmodulation
Thomas A. Reh[US];Paul Nakamura[US];Sheng Ding [US]
Publicationdate: 2019-07-30 | Patent publication No.: US-10363256-B2|Assignees: University of Washington [US]; The J. David Gladstone Institutes, aTestamentary Trust Established Under the Will of J. David Gladstone [US] | IPC: A61K9/00;A61P27/02; A61K31/426; A61K31/519; C07D495/04 | Oldest priority date: 2015-03-27 | Publication date: 2019-07-30
Score: 18.390413 | Text size: 64233 | Find: similardocuments
(I) isCA8801: [[image:EMI-C00006]] Compounds CA88 and CA8801 are commercially availablefrom ChemDiv(San Diego, Calif. ... (II) is CA9513:[[image:EMI-C00010]] Compounds CA95 and CA9513 are commercially availablefrom ChemDiv (San Diego, Calif. ... Nr2e3 interactingmolecules specifically identified herein were obtained commercially from ChemDiv (SanDiego, Calif.
Methods for identifying subjects with a genetic risk for developing IgAnephropathy
Ali Gharavi [US]; KrzysztofKiryluk [US]; Richard Lifton[US]
Publicationdate: 2019-07-23 | Patent publication No.: US-10358678-B2|Assignees: The Trustees of Columbia University in the City of New York [US]; YaleUniversity [US] | IPC: C12Q1/6883 | Oldestpriority date: 2011-02-17 | Publication date: 2019-07-23
Score: 12.484504 | Text size: 190979 | Find: similardocuments
(A divisionof Key Organics Limited), Camelford, UK; ChemBridge Corporation, San Diego,Calif.; ChemDiv Inc., San Diego, Calif.; ChemRx AdvancedTechnologies, South San Francisco, Calif.; ComGenex Inc.
Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
Kayvan Niazi[US];ShahroozRabizadeh [US]; Anne-Laure Le Ny[US];Oleksandr Buzko[US];Justin Golovato[US];PatrickSoon-Shiong [US]
Publicationdate: 2019-07-16 | Patent publication No.: US-10350225-B1|Assignees: Nant Holdings IP, LLC [US] | IPC: C07D417/12; A61K31/635; A61K31/55; A61K31/501; A61K31/5377; A61K31/47;A61K31/4409; A61K31/4709; A61K31/496; A61K31/4545; A61K31/444; A61K31/426;A61K31/454; G16B5/00 | Oldestpriority date: 2013-01-31 | Publication date: 2019-07-16
Score: 14.692947 | Text size: 57917 | Find: similardocuments
(ChemDiv,
METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITIONCONTAINING STABILIZED SWEET ENHANCER
CatherineTachdjian [US]; DonaldKaranewsky [US]; Xiao Qing Tang[US];Hanghui Liu [US]
Publicationdate: 2019-07-11 | Patent publication No.: US-20190208802-A1|Assignees: Senomyx, Inc. [US] | IPC: A23L2/56; A23L27/00; A61K47/26; A23L27/20; A61K47/22 | Oldest priority date: 2010-08-12 | Publication date: 2019-07-11
Score: 8.557886 | Text size: 449476 | Find: similardocuments
other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.
FIELDS, Mark[US];DEL PRIORE,Lucian [US];CAI, Huey [US]; HOYER, Denton[US]
Publicationdate: 2019-07-11 | Patent publication No.: WO-2019136466-A1|Assignees: YALE UNIVERSITY [US] | IPC: A61K31/4412; A61K31/519; A61P27/02 | Oldest priority date: 2018-01-08 | Publication date: 2019-07-11
Score: 16.402758 | Text size: 100248 | Find: similardocuments
As usedherein,“compound 414” or“YU 162779-01” refers to ChemDiv librarycompound number C325-0414, or a salt, solvate or hydrate thereof, having theformula: [[image:imgf000013_0001]] As used herein,“compound 434”or“YU162787-01” refers to ChemDiv library compound numberC325-0434, or a salt, solvate or hydrate thereof, having the
Soluble CD33 for treating myelodysplastic syndromes (MDS)
Alan F. List[US];Sheng Wei [US]
Publicationdate: 2019-07-09 | Patent publication No.: US-10344072-B2|Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc. [US] | IPC: A61K38/17;C07K19/00; C07K14/705; A61K47/00; A61K47/50; G01N33/68; A61K47/69; C07K14/735;A61K38/00 | Oldestpriority date: 2013-07-05 | Publication date: 2019-07-09
Score: 11.918776 | Text size: 178331 | Find: similardocuments
Corporation(16981 Via Tazon, Suite G, San Diego, Calif., 92127, USA,www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, SanDiego, Calif.
Sara Buhrlage[US];Ellen Weisberg[US];James D. Griffin[US]
Publicationdate: 2019-07-04 | Patent publication No.: US-20190202929-A1|Assignees: Sara BUHRLAGE [US]; Ellen WEISBERG [US]; James Douglas GRIFFIN [US];Dana-Farber Cancer Institute, Inc. [US] | IPC: C07K16/30;C12Q1/686; C12Q1/6806; A61P35/02; C12Q1/02; C12Q1/6841; C12Q1/6851; A01K67/027|Oldestpriority date: 2016-09-20 | Publication date: 2019-07-04
Score: 7.874651 | Text size: 455531 | Find: similardocuments
HBX19818analogs were purchased from ChemDiv and dissolved in DMSO toobtain a 10 mM stock solution.
ALPHA- AND GAMMA-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICALCOMPOSITIONS THEREOF
Iwao Ojima [US]; Dale Deutsch[US];Martin Kaczocha[US];William T.Berger [US];Robert Rizzo[US];Trent E. Balius[US]
Publicationdate: 2019-07-04 | Patent publication No.: US-20190201365-A1|Assignees: The Research Foundation for The State University of New York [US] | IPC: A61K31/216;C07C69/76; A61K31/194; G01N33/68; C07C67/08; C07C211/58; C07C69/757;C07C69/753; G01N33/566; C07C67/48; C07C235/40; C07C235/38; C07C233/58;C07C233/11 | Oldestpriority date: 2012-07-20 | Publication date: 2019-07-04
Score: 19.91218 | Text size: 140509 | Find: similardocuments
EnergeticallyDOCK selected ligands from the ChemDiv library that did nothave unfavorable interaction, both VDW and ES, intrinsically selecting ... The followingcompounds are available from ChemDiv (San Diego, Calif., USA):StructureChemDiv ID Number [[image:EMI-C00036]] 8009-2334[[image:EMI-C00037]] 8009-3434 [[image:EMI-C00038]] ... acid was from CaymanChemical (Ann Arbor, Mich.). 48 virtually screened test compounds from ChemDiv,Inc. (Moscow, Russia). ... Competitors included arachidonic acid,BMS309403, 48 test compounds from ChemDiv library, Compound 26and Compound 49. ... Virtual Screening A high-throughput virtual screening ofover one million molecules from the ChemDiv subset of the ZINCdatabase (http://zinc.docking.
USE OF IMIDAZOPYRIMIDINE FOR MODULATING HUMAN IMMUNE RESPONSE
LEVY, Ofer [US]; DOWLING, DavidJ. [US];BORRIELLO,Francesco [US]; SCOTT, David A.[US];BRIGHTMAN,Spencer E. [US]; FERU, Frederic[US]
Publicationdate: 2019-05-23 | Patent publication No.: WO-2019099578-A1|Assignees: CHIDREN'S MEDICAL CENTER CORPORATION [US]; DANA-FARBER CANCER INSTITUTE,INC. [US] | IPC: A61K31/52; C07D473/32 | Oldestpriority date: 2017-11-14 | Publication date: 2019-05-23
Score: 13.4640045 | Text size: 324834 | Find: similardocuments
bioactiveand commercial libraries from various sources including commercial librariessuch as ChemDiv, ChemBridge, and Asinex (see attached pdf of alllibraries). ... known bioactive and commercial libraries from various sources (e.g.,commercial libraries such as ChemDiv, ChemBridge, and Asinex; seeattached pdf of all libraries).
NOVEL IMIDAZOPYRIMIDINE COMPOUNDS AND USES THEREOF
LEVY, Ofer [US]; DOWLING, DavidJ. [US];BORRIELLO,Francesco [US]; SCOTT, David, A[US];BRIGHTMAN,Spencer E. [US]; FERU, Frederic[US]
Publicationdate: 2019-05-23 | Patent publication No.: WO-2019099564-A1|Assignees: CHILDREN'S MEDICAL CENTER CORPORATION [US]; DANA-FARBER CANCER INSTITUTE,INC. [US] | IPC: A61K31/4188; A61K31/519; C07D487/04; A61P37/02 | Oldest priority date: 2017-11-14 |Publicationdate: 2019-05-23
Score: 13.4640045 | Text size: 269157 | Find: similardocuments
bioactiveand commercial libraries from various sources including commercial librariessuch as ChemDiv, ChemBridge, and Asinex (see attached pdf of alllibraries). ... known bioactive and commercial libraries from various sources(e.g., commercial libraries such as ChemDiv, ChemBridge, andAsinex; see attached pdf of all libraries).
Hakon Hakonarson[US];Berta Almogurea[US];Lyam M. Vasquex[US];Patrick M.a.Sleiman [US]
Publicationdate: 2019-05-23 | Patent publication No.: US-20190153523-A1|Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/6827;C12Q1/6883; A61K45/06; A61P11/06 | Oldestpriority date: 2016-07-21 | Publication date: 2019-05-23
Score: 12.484504 | Text size: 171594 | Find: similardocuments
Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.
Michael YoonsukCHOI [US];Byeong-Moo KIM[US]
Publicationdate: 2019-05-16 | Patent publication No.: US-20190144862-A1|Assignees: THE GENERAL HOSPITAL CORPORATION [US] |IPC: C12N15/113; A61K35/407; A61P1/16 | Oldestpriority date: 2016-05-20 | Publication date: 2019-05-16
Score: 11.569273 | Text size: 199903 | Find: similardocuments
for example,from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive ChemistryLtdTM, ChemDiv, ChemBridgeTM, TimTec IncTM, AsisChemTM, andPrinceton Biomolecular ResearchTM, among others.
ISL1-Based Gene Therapy to Treat Hearing Loss
Zheng-Yi Chen[US];Yujuan Ju [US]
Publicationdate: 2019-05-16 | Patent publication No.: US-20190142969-A1|Assignees: Massachusetts Eye and Ear Infirmary [US] | IPC:A61K48/00; A61K38/17; A61P27/16 | Oldestpriority date: 2016-04-26 | Publication date: 2019-05-16
Score: 12.484504 | Text size: 137874 | Find: similardocuments
availablecompound libraries (suppliers include Chembridge Corp (San Diego, Calif.)and ChemDiv (San Diego, Calif.)).
COMPOSITIONS AND METHODS FOR THE INHIBITION OF PRURITUS
HOON, Mark A.[US];SOLINSKI, HansJuergen [DE]; INGLESE, James[US];DRANCHAK,Patricia [US]; HOON, Mark A.[US];SOLINSKI, HansJuergen [DE]; INGLESE, James[US];DRANCHAK,Patricia [US]
Publicationdate: 2019-05-09 | Patent publication No.: WO-2019090039-A1|Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENTOF HEALTH AND HUMAN SERVICES [US] | IPC: A61K31/422; A61K31/4184; A61K31/015; A61K31/42; A61K31/437; A61K31/439;A61K31/4545; A61K31/4985; A61K31/506; A61K31/519; A61K31/55; A61K31/5513;A61K31/5517; A61P17/04; A61P43/00 | Oldestpriority date: 2017-11-03 | Publication date: 2019-05-09
Score: 18.04004 | Text size: 92160 | Find: similardocuments
a][l,4]diazepine-4,4'-piperidin]-r-yl)methanone(Chemdiv Inc., catalog number S217-0244); (m)N-benzyl-l-(2-cyanobenzyl)-4-oxo-l ,5-diazacycloundecane-8-carboxamide (ChemdivInc., catalog number S733-0866); or (n)N-benzyl-N-methyl-8-phenylimidazo[l,2-a]pyrazine-2-carboxamide (Chemdiv Inc.,catalog number T425-0460).
ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME
Dan THEODORESCU[US];MichaelFitzpatrick WEMPE [US]; David ROSS [US]; Chao YAN [US]; Phillip REIGAN[US]
Publicationdate: 2019-05-09 | Patent publication No.: US-20190135824-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate [US] | IPC: C07D491/052;A61K31/4162; A61K45/06 | Oldestpriority date: 2014-07-10 | Publication date: 2019-05-09
Score: 12.290053 | Text size: 139037 | Find: similardocuments
The ChemDiv library[v2006.
COMPOSITIONS AND METHODS FOR THE INHIBITION OF PRURITUS
Mark A. Hoon[US];Hans JuergenSolinski [DE]; James Inglese[US];PatriciaDranchak [US]
Publicationdate: 2019-05-09 | Patent publication No.: US-20190135804-A1|Assignees: The United States of America,as represented by the Secretary,Department ofHealth and Human Services [US] | IPC: C07D471/04; C07D487/04; C07D413/12; A61P17/04 | Oldest priority date: 2017-11-03 | Publication date: 2019-05-09
Score: 18.248644 | Text size: 72732 | Find: similardocuments
(ChemdivInc., catalog number S217-0244); (m)N-benzyl-1-(2-cyanobenzyl)-4-oxo-1,5-diazacycloundecane-8-carboxamide (ChemdivInc., catalog number S733-0866); or (n)N-benzyl-N-methyl-8-phenylimidazo[1,2-a]pyrazine-2-carboxamide (Chemdiv Inc.,catalog number T425-0460).
SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS AND MESENCHYMAL CANCERTYPES
LAIRSON, Luke L.[US];BOLLONG, MichaelJ. [US];SCHULTZ, PeterG. [US];MANI, SenduraiA. [US]
Publicationdate: 2019-05-09 | Patent publication No.: WO-2019089577-A1|Assignees: THE SCRIPPS RESEARCH INSTITUTE [US]; BOARD OF REGENTS, THE UNIVERSITY OFTEXAS SYSTEM [US] | IPC: A61K31/437; A61K31/4704; A61K31/4741; A61K31/497; A61K31/498; A61K31/4985;A61K31/502; A61K31/551; A61P35/04 | Oldestpriority date: 2017-10-30 | Publication date: 2019-05-09
Score: 16.930674 | Text size: 99538 | Find: similardocuments
Selected hitcompounds were reordered from ChemDiv and tested for selectivetoxicity in 10-point response assays as above. ... a library of -50,000 diverseheterocyclic compounds and biologically active small molecules (ChemDiv,San Diego, CA, USA) for cytotoxic activity against both cell lines, [00139] Preliminaryscreening
METHODS AND COMPOSITIONS TO TREAT CANCER
Jeffrey A.Whitsett [US]; Yutaka Maeda[US];Takuya Fukazawa[JP]
Publicationdate: 2019-05-09 | Patent publication No.: US-20190134053-A1|Assignees: Takuya FUKAZAWA [JP]; Children's Hospital Medical Center [US] | IPC: A61K31/5377;A61K31/429; A61K31/444; A61K31/4375; A61P35/00 | Oldest priority date: 2016-07-28 | Publication date:2019-05-09
Score: 14.557414 | Text size: 46365 | Find: similardocuments
(hereinafter “iMDK” (Compound A, below) was purchased from ChemDiv (SanDiego, Calif.
Methods to identify modulators of RyR calcium channels
Razvan L. Cornea[US];Donald M. Bers[US];David D. Thomas[US];Gregory D.Gillispie [US]
Publicationdate: 2019-05-07 | Patent publication No.: US-10281476-B2|Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA [US] |IPC: G01N31/00; G01N33/53; G01N33/68 | Oldestpriority date: 2013-12-10 | Publication date: 2019-05-07
Score: 12.290053 | Text size: 179884 | Find: similardocuments
and includeAMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridgeLibrary, ChemDivLibrary, Enamine Library, The Greenpharma NaturalCompound Library, Life Chemicals Library,
Mayland CHANG[US];ShahriarMobashery [US]; Edward Spink[GB];Derong Ding [US]; SebastianTestero [AR]; Erika Leemans[BE];Marc Boudreau[US]
Publicationdate: 2019-05-02 | Patent publication No.: US-20190127340-A1|Assignees: University Of Notre Dame Du Lac [US] | IPC:C07D271/107; C07D413/04; C07F9/653; C07D471/04 | Oldest priority date: 2014-09-25 | Publication date: 2019-05-02
Score: 14.999643 | Text size: 177982 | Find: similardocuments
A library of1.2 million drug-like compounds from the ChemDiv subset of theZINC database (Irwin et al., J. Chem. Inf. Model. ... From these, 29 compoundswere selected and purchased from ChemDiv for in vitro activityexperiments. Syntheses.
Isolated human lung progenitor cells and uses thereof
JayarajRajagopal [US]; Hongmei Mou [US]
Publicationdate: 2019-04-30 | Patent publication No.: US-10273450-B2|Assignees: THE GENERAL HOSPITAL CORPORATION [US] | IPC:C12N5/074; A61K35/42; A61L27/38; A61L27/56; A61L27/58; G01N33/68;C12N5/071; A61K9/00 | Oldestpriority date: 2012-01-13 |Publicationdate: 2019-04-30
Score: 9.838301 | Text size: 266887 | Find: similardocuments
for example,from Enzo Life SciencesTM, Aurora Fine ChemicalsTM Exclusive ChemistryLtd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, andPrinceton Biomolecular ResearchTM, among others.
Subunit selective NMDA receptor potentiators for the treatment ofneurological conditions
Stephen F.Traynelis [US]; Dennis C. Liotta[US];Rose M.Santangelo [US]; Ethel C. Garnier[US]
Publicationdate: 2019-04-30 | Patent publication No.: US-10273214-B2|Assignees: Emory University [US] | IPC: C07D217/16; C07D491/056; C07D409/06; C07D405/06; C07D401/06; C07D413/06;C07D409/04; C07D401/04; C07D277/34; C07D263/58; C07D239/88; C07D215/22;C07D209/08 | Oldestpriority date: 2009-01-28 | Publication date: 2019-04-30
Score: 16.882145 | Text size: 168432 | Find: similardocuments
molecules,such as beta-turn mimetic libraries and the like, may be purchased from forexample ChemDiv, Pharmacopia or Combichem or synthesized and aredescribed in Tietze and Lieb, Curr. Opin. Chem. ... For example, ChemDiv usesmore than 800 individual chemical cores, a unique Building Block Library, andproprietary ... In addition, ChemDiv's compounds are designed toensure their similarity to drugs adjusted according to proprietary
Alexander V.Statsyuk [US]; Stefan G.Kathman [US]
Publicationdate: 2019-04-30 | Patent publication No.: US-10273208-B2|Assignees: Northwestern University [US] | IPC: G01N33/68; H01J49/00; H01J49/16; C07C235/40; C07D209/42; C07D231/56;C07D307/84; C07D471/04 | Oldestpriority date: 2014-05-23 | Publication date: 2019-04-30
Score: 11.918776 | Text size: 196210 | Find: similardocuments
fromAccelrys, 94,275 commercially available carboxylic acids were identified fromthe ChemBridge, ChemDiv, MayBridge, NCI and Sigma-Aldrich librariesusing SMARTS query strings.
Methods of treating muscular dystrophy
Dean Burkin [US]; Ryan Wuebbles[US]
Publicationdate: 2019-04-30 | Patent publication No.: US-10272069-B2|Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THEUNIVERSITY OF NEVADA, RENO [US] | IPC: A61K31/40; A01N43/38; A61K31/404; A61K45/06 | Oldest priority date: 2012-09-10 | Publication date: 2019-04-30
Score: 14.450268 | Text size: 238806 | Find: similardocuments
Heidelberg);the DIVERSet library (Chembridge Corp., San Diego, Calif.) and compounds fromthe ChemDivlibrary. ... α7 integrin Compound (ObtainedIncreased A7 Expression Commercially from Myotubes + MyoblastsChemDiv Library)EC100 Myoblasts Only 5α-cholestan-3β-ol-6-oneN032-0003 N066-0070 N069-0071 N069-0075
TAF1 INHIBITORS FOR THE THERAPY OF CANCER
Sara SDELCI [AT]; Stefan KUBICEK[AT]
Publicationdate: 2019-04-25 | Patent publication No.: US-20190117641-A1|Assignees: CeMM - Forschungszentrum für Molekulare Medizin GmbH [AT] | IPC: A61K31/4725;A61P35/00; A61K31/22; A61K31/517; A61K31/5517 | Oldest priority date: 2016-02-15 | Publication date: 2019-04-25
Score: 10.354719 | Text size: 235623 | Find: similardocuments
CompoundsA2, A3, A4 and A5 were purchased from ChemDiv (San Diego,USA). Synthesis of all other analogs was carried out by Enamine Ltd.
MITOFUSIN ACTIVATORS AND USES THEREOF
GAVATHIOTIS,Evripidis [US]; KITSIS, Richard,N. [US];BIRIS, Nikolaos[US];ZACHARIOUDAKIS,Emmanouil [US]
Publicationdate: 2019-04-25 | Patent publication No.: WO-2019079243-A1|Assignees: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. [US] | IPC: A01K67/027;C12N15/85; C12N15/877 | Oldestpriority date: 2017-10-17 | Publication date: 2019-04-25
Score: 14.293713 | Text size: 58596 | Find: similardocuments
ScreenedMASMs were purchased from Enamine, ChemBridge and ChemDiv.
Plasmodial surface anion channel inhibitors for the treatment orprevention of malaria
Publicationdate: 2019-04-23 | Patent publication No.: US-10265313-B2|Assignees: The United States of America, as represented by the Secretary, Departmentof Health and Human Services [US] | IPC: A61K31/4985; A61K31/501; A61K31/496; C07D413/14; C07D409/04; C07D409/14;C07D239/84; C07D417/06; C07D241/44; C07D263/57; C07D491/048; C07D498/04;C07D277/54; C07D513/04; C07D281/16; A61K31/42; A61K31/433; A61K31/495;A61K31/498; A61K31/50; A61K31/519; A61K31/554; C07K14/445; A61K31/422;A61K31/4741; A61K31/517; A61K39/015; C07K16/20; A61K45/06; A61K31/423;A61K31/427; A61K31/4355; A61K31/437; A61K31/4439 | Oldest priority date:2011-04-12 | Publication date: 2019-04-23
Score: 15.906768 | Text size: 142600 | Find: similardocuments
methods aswould be known to those skilled in the art or obtained from commercial sourcessuch as ChemDiv Inc., San Diego, Calif. or Peakdale MolecularLimited, High Peak, England. ... room temperature using a commercial library of50,000 compounds with >90% purity confirmed by NMR (ChemDiv). Screenswere performed in 384-well format with individual wells containing a singlecompound at
Complement C3d-binding compounds
DimitriosMorikis [US]; Ronald D.Gorham, Jr. [US]
Publicationdate: 2019-04-16 | Patent publication No.: US-10259824-B2|Assignees: The Regents of the University of California [US] | IPC:C07D495/04; C07D249/04; C07D417/14; C07D471/04; A61P27/02; A61K31/165 | Oldest priority date: 2015-05-01 | Publication date: 2019-04-16
Score: 13.793969 | Text size: 93675 | Find: similardocuments
Selecteddrug-like compounds were obtained from Enamine, Pharmeks, ChemDiv,ChemBridge, and Maybridge.
TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS
Steven AlbertEverett [US]; Saraj Ulhaq [GB]
Publicationdate: 2019-02-28 | Patent publication No.: US-20190060472-A1|Assignees: University Court of the University of Dundee [GB] | IPC: A61K47/54;C07D491/22; A61K31/513; C07D417/12; C07D409/12; C07D407/12; C07D405/14;C07D405/12; C07D405/04; C07D311/18; C07D311/16; C07D307/80; A61K31/664;A61K31/428; A61K31/4184; A61K31/352; A61K31/343; A61K31/52; A61K31/665;A61K31/37; A61K31/381; C07D487/04 | Oldestpriority date: 2009-05-01 | Publication date: 2019-02-28
Score: 16.189404 | Text size: 219848 | Find: similardocuments
for CYP1B1The target enzyme CYP1B1 was screened against two commercial librariesincluding the ChemDivDiversity 50,000 test compound collection andthe ChemDiv Kinase Targeted 10,000 test compound collectionwith a view to identifying activity differentiating ... cross validation on atraining set selected from 45,000 and 9,000 test compounds from the ChemDiv Diverseand Kinase libraries.
STRUCTURE OF PLASMEPSIN V IN COMPLEX WITH AN INHIBITOR AND USES THEREOF
Justin BODDEY[AU];Alan COWMAN [AU]; Peter CZABOTAR[AU];Tony HODDER [AU]; Brad SLEEBS [AU]
Publicationdate: 2019-02-28 | Patent publication No.: US-20190065668-A1|Assignees: THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH [AU] | IPC: G06F19/16 | Oldest priority date: 2015-06-09 | Publication date: 2019-02-28
Score: 7.2924438 | Text size: 927233 | Find: similardocuments
from, forexample, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest,Hungary) and ChemDiv(San Diego, Calif.), Specs (Delft, The Netherlands).
Guy Servant [US]; Hong Chang [US]; Cyril Redcrow[US];Sumita Ray [US]; Imran Clark [US]; Bryan Moyer [US]
Publicationdate: 2019-02-26 | Patent publication No.: US-10215759-B2|Assignees: SENOMYX, INC. [US] | IPC: C12Q1/02; C12N15/85; G01N33/50; G01N33/68 | Oldest priority date: 2001-05-01 | Publication date: 2019-02-26
Score: 12.484504 | Text size: 153665 | Find: similardocuments
It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.
Iwao Ojima [US]; Dale Deutsch[US];Martin Kaczocha[US];William T.Berger [US];Robert Rizzo[US];Trent E. Balius[US]
Publicationdate: 2019-02-26 | Patent publication No.: US-10213406-B2|Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK [US] | IPC: A61K31/216;C07C67/08; C07C211/58; C07C233/11; C07C233/58; C07C235/38; C07C235/40;C07C69/753; C07C69/76; C07C67/48; C07C69/757; G01N33/566; A61K31/194; G01N33/68|Oldestpriority date: 2012-07-20 | Publication date: 2019-02-26
Score: 19.91218 | Text size: 149952 | Find: similardocuments
EnergeticallyDOCK selected ligands from the ChemDiv library that did nothave unfavorable interaction, both VDW and ES, intrinsically selecting ... Thefollowing compounds are available from ChemDiv (San Diego,Calif., USA): StructureChemDiv ID Number [[image:EMI-C00036]] 8009-2334[[image:EMI-C00037]] 8009-3434 [[image:EMI-C00038]] ... acid was from CaymanChemical (Ann Arbor, Mich.). 48 virtually screened test compounds from ChemDiv,Inc. (Moscow, Russia). ... Competitors included arachidonic acid,BMS309403, 48 test compounds from ChemDiv library, Compound 26and Compound 49. ... Virtual Screening A high-throughput virtual screening ofover one million molecules from the ChemDiv subset of the ZINCdatabase (http://zinc.docking.