Anti-Aging Library
Preferred format
Desirable size of the custom library selection
Number of compounds
Amount
Volume
uL
Description
Target Identification, Phenotypic Screening Library.
Methodology and machine learning knowledge.
Examples of pathways – caloric restriction, oxidative stress regulation, sirtuins regulation, epigenetic modification, dopaminergic projections
• Examples of biological targets – TOR1, SCH9, GCN2, 8002, SIRT1, VEGF, ALOX5, PDE3, PDE7, HTR, CDK1, KCNK1, Serine proteases
• Examples of structural chemotypes – antioxidants, flavonoids, quinoids, tetracycline antibiotics, radical traps, adrenergic compounds
Publications
•Ye, X.; Petrascheck, M. et al. (2014) A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell 13, 206–215.
•Engel, N.; Mahlknecht, U. (2008) Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation. Int. J. Mol. Med. 21, 223–232.
•Wood, J.G.; Rogina, B. et al. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686–689.
•Petrascheck, M.; Ye, X.; Buck, L.B. (2007) An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature 450, 553–556.
•Lublin, A.; et al. (2011) FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. PLoS One 6:e27762.
•Iouk, T.; Titorenko, V.I. (2017) A laboratory test of evolutionary aging theories. Aging (Albany NY) 9(3), 600–601.
•Wu, Z. et al. (2014) Tanshinones extend chronological lifespan in budding yeast Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 98, 8617–8628.
•Engel, N.; Mahlknecht, U. (2008) Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation. Int. J. Mol. Med. 21, 223–232.
•Wood, J.G.; Rogina, B. et al. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686–689.
•Petrascheck, M.; Ye, X.; Buck, L.B. (2007) An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature 450, 553–556.
•Lublin, A.; et al. (2011) FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. PLoS One 6:e27762.
•Iouk, T.; Titorenko, V.I. (2017) A laboratory test of evolutionary aging theories. Aging (Albany NY) 9(3), 600–601.
•Wu, Z. et al. (2014) Tanshinones extend chronological lifespan in budding yeast Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 98, 8617–8628.
