Cardiovascular
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39,301 compounds
Set of covalent inhibitors with warheads that target cysteine.
5000 compounds
Cytosolic phospholipase A2 (GIVA cPLA2) is involved in a number of inflammatory diseases. Synthetic inhibitors of GIVA cPLA2 attracted great interest as potential antiinflammotory drugs
1400 compounds
The library contains 1400 compounds that seems to be analogues of approved drugs.
5,886 compounds
SH2 PTB domains Focused Library is a set of inhibitors. SH2 and PTB are small protein modules that mediate PPIs involved in signal transduction pathways.
31,972 compounds
Serine Proteases Inhibitors Library is a set of small-molecule compounds that target serine proteases and can be used in anticancer drug discovery.
1,156 compounds
Purine Based Nucleoside Mimetics Library is nucleoside analogues that mimic metabolic purines. They are extracellular messengers and endogenous modulators.
2,292 compounds
Nucleoside Mimetics Library is a set of modified nucleosides that are used as antiviral and antitumor drugs. They were also designed for HIV therapy.
9,000 compounds
Nucleic Acid Ligands is a set of minor and major groove DNA or RNA binders. Such small molecules have proven to be effective antiviral and cancer agents.
4,805 compounds
MEF2-HDAC (class II) Modulators Library is a set of drug-like compounds aimed at modulating PPI of MEF2 with HDAC involved in physiological processes.
23,319 compounds
MDM2-p53 Interaction Inhibitors Library is a set of drug-like compounds aimed at modulating PPI of MDM2 with p53 involved in tumorigenesis.
8,000 compounds
Inhibitors of beta-Catenin Signaling is small molecules that target PPI of beta-catenin with other proteins involved in significant physiological processes.
7,801 compounds
Set of small-molecule compounds that can target cysteine proteases and be used in drug development for cancer, viral, infections treatment.
11,568 compounds
Bcl2 PPI Inhibitors Library is small molecules that inhibit regulators of programmed cell death.
4,550 compounds
Autophagy-Targeted Library is a set of small-molecule modulators for the regulation of autophagy.
17,000 compounds
Angiogenesis Library is a set of small-molecule compounds that target proteins involved in new blood vessels forming.
23,032 compounds
Regenerative Medicine Focused Library is a chemical space that includes promoters of regeneration. They help to repair diseased organs or tissues.
3,271 compounds
Purinergic Library is a set of purinergic receptor antagonists. Such antagonists are used for thrombosis and stroke treatment.
22,214 compounds
Macl-GPIb alpha set targets leukocyte-platelet interaction. This leads to an antithrombotic effect.
9,149 compounds
Lipid Metabolism Library is a set of small-molecule modulators of proteins involved in lipid metabolism.
23,000 compounds
Cardiovascular Library is a set of small-molecule compounds with vast target space for cardiovascular disease drug discovery.
28,000 compounds
Anti-Inflammatory Library is a set of small-molecule compounds that target pivotal proteins and receptors participating in the inflammatory process.
3,051 compounds
Angiotensin-converting enzyme Library is a set of small-molecule inhibitors of the SARS-CoV-2 binding site.
4,723 compounds
Voltage-Gated Ion Channel-Targeted set is small molecule compounds that contribute to treating pain.
10,813 compounds
Neurotransmitter Transporter Inhibitors Library is a set of small-molecule inhibitors. They are used to treat mental disorders.
3,743 compounds
Ligand-Gated Ion Channels Library is a set of small-molecule compounds that target LGICs. They can be used in the treatment of neurodegenerative disorders.
28,284 compounds
CNS MPO Library is a set of drug-likeness designed via Multi-Parameter Optimization for improved BBB-permeability.
23,432 compounds
CNS BBB Library is a set of blood-brain barrier permeable compounds with high chemical diversity and novelty of structures.
7,123 compounds
Set of GABA receptor antagonists. These drug-like compounds inhibit the action of GABA and produce stimulant and convulsant effects.
21000 compounds
Adenosine Receptors Targeted Library is a set of small-molecule ligands. They can be used for treating neurodegeneration diseases.
26,421 compounds
Ion Channels Focused Library is small-molecule compounds selected for modulating ion channels proteins. They are therapeutic targets of CNS diseases.
6500 compounds
Set of small-molecule compounds that can target Factor XIa
6,767 compounds
Set of RAR receptor antagonists. The retinoic acid receptor is a type of nuclear receptor which can also act as a transcription factor.
5,939 compounds
STING Agonist Library is small-molecules that bind and activate STING and lead to IFN production. Can be used in cancer immunotherapy.
1,708 compounds
Integrin Receptors Targeted library is a set of RGD peptides or peptidomimetics that affect many events in tumor cells thereby directly induce apoptosis.
5,000 compounds
BRD4 Targeted Library is a set of small-molecule compounds that inhibit transcriptional and epigenetic regulator - BRD4.
2,016 compounds
Arginase Targeted Library is a set of small-molecule compounds against arginase. This enzyme is implicated in cancer immunosuppression and tumor growth.
20,563 compounds
Spiro Library is a set of scaffolds with twisted structure of two or more rings for the design of new therapeutic agents.
23,943 compounds
Recognition Elements PPI Library includes conformationally constrained analogues of bioactive peptides: gamma-, beta-turns, dipeptide mimetics.
214,102 compounds
PPI Library is a set of small-molecule modulators that have been designed for disrupting PPI and reducing its drawbacks.
68,388 compounds
PPI Helix Turn 3D Mimetics Library was designed on sp3-enriched scaffolds that mimic key recognition elements of protein secondary structure.
2,335 compounds
Macrocycles Library is a set of macrocyclic peptidomimetics that are potential PPI modulators. It is unique spiro and fused scaffolds.
9,487 compounds
Set of PPI modulators. Cyclic lactam amides result from the Ugi reaction of bifunctional keto carboxylic acids.
4200 compounds
The use of covalently binding inhibitors is steadily growing, with numerous molecules progressing through the stages of clinical trials and even make it to become marketed drugs.
24,737 compounds
Alpha-Helix Mimetics Library is a set of peptidomimetics. Alpha-helices are key recognition elements of protein secondary structure.
1,503 compounds
3D Mimetics PPI Library is a set of small-molecule compounds that mimic key recognition elements of protein secondary structure.
498 compounds
Steroid-like compounds library is steroid-based molecules that regulate biological function. These synthetic steroids can treat inflammation.
12,563 compounds
Set consists of sp3-enriched β-lactams, generic library of covalent inhibitors, smart library of covalent inhibitors, smart library of covalent fragments.
799 compounds
Smart library of covalent inhibitors and fragments with a wide range of reactivity warheads.
Tags
Custom ChemistryNovel Scaffolds and Discovery LibrariesCustom Building Blocks for DNA Encoded LibrariesScale up SynthesisMacrocycle CompoundsIn silico Drug Design (CADD)PROTACADME, DMPKMedicinal ChemistryDNA Encoded Libraries-CDI-CapabilitiesDiscovery BiologyAssay DevelopmentHigh Throughput Screening (HTS)Animal ModelsToxicology and SafetyChemistry, Manufacturing and ControlsPre-Plated SetRepresentative CompoundsNatural-Product3D-PharmacophoreMCE-18RepresentativeSoluble DiversityTargeted DiversitySmartTMAntiviralGPCR3DPhenotypic ScreeningCNS activityTranscription FactorsDrugs LibraryTarget ActivityTherapeutical DiversityCNSIon ChannelsProteases HumanKinases HumanPhosphatases HumanReceptors HumanOpportunistic PathogensCancerCardiovascularMetabolicImmune systemInfectionsMusculoskeletalDigestive systemRespiratory tractOtorhinolaryngologicNervous systemEyeMaleFemaleHemic and lymphaticCongenitalSkinEndocrineAnimalWoundsKinasesProteasesPhosphatasesNuclear receptorsOthersPPI modulatorsReceptor's ligandsEpigeneticMimeticsCyclic compoundsFragmentsPoolChemical classes AgroAllosteric Inhibitors