Your cart is empty.
Beyond the Flatland Library sp3 enriched

Beyond the Flatland Library sp3 enriched

Files to download
Preferred format
Desirable size of the custom library selection
Number of compounds
Amount
Volume
uL
Description

ChemDiv’s Beyond the Flatland Library contains 93,483 compounds.

“Escape from Flatland” – New Approach for Scaffold & Library Design. Fsp3 = number of sp3-hybridized carbons/ total carbon count.

The increase of scaffold/molecule saturation leads to:
More diverse set of compounds
More highly complex molecules
Natural product-likeness
Access to greater chemical space
Better complement to the spatial subtleties of target proteins
3D-dimensionality may result in greater selectivity
Higher water solubility
Better phys-chemical parameters (logP and PSA)
Very low increase of MW
New stereo-centers

As result: Faster transition of compound from discovery to drugs.

Publications
  • Tsaloev A., Ilyin A., Tkachenko S., Ivachtchenko A., Kravchenko D., Krasavin M. Cyclic products of the Ugi reaction of aldehydo and keto carboxylic acids: chemoselective modification. Tetrahedron Letters. 2011, 52: 1800–1803.
  • Kysil V., Khvat A., Tsirulnikov S., Tkachenko S, Williams C., Churakova M., Ivachtchenko A. General Multicomponent Strategy for the Synthesis of2-Amino-1,4-diazaheterocycles: Scope, Limitations, and Utility. European Journal of Organic Chemistry. 2010; 1525–1543.
  • Kysil V.M., Khvat A., Tsirulnikov S., Tkachenko S., Ivachtchenko A. Multicomponent approach to unique 1,4-diazepine-2-amines. TetrahedronLetters. 2009; 50(24): 2854-2856.
  • Balakin K.V., Ivanenkov Y.A., Tkachenko S.E., Kiselyov A.S., Ivachtchenko A.V. Regulators of chemokine receptor activity as promising anticancer therapeutics. Current Cancer Drug Targets.2008; 8(4): 299-34.
  • Kiselyov A.S., Tkachenko S.E., Balakin K.V., Ivachtchenko A.V. Small-molecule modulators of Hh and Wnt signaling pathways. Expert Opinion on Therapeutic Targets. 2007; 11(8): 1087-1101.
  • Savchuk N.P., Tkachenko S.E., Balakin K.V. Design of pGPCR-targeted Libraries. In Rognan D., ed. Ligand Design for G Protein-coupled Receptors.Methods and Principles in Medicinal Chemistry (Volume 30). Weinheim: Wiley VCH. 2006, pp. 137-164.
  • Kysil V., Tkachenko S., Khvat A., Williams C., Tsirulnikov S., Churakova M., Ivachtchenko A. TMSCl-Promoted Isocyanide-Based MCR of Ethylenediamines: an Efficient Assembling of 2-Aminopyrazine Core. Tetrahedron Letters, 2007; 48(36): 6239-6244.
X
X
Send a message
Request a call

Your Name*

Your E-mail*

Company*

Type in your message here…*
* Required fields

By submitting this form you confirm that you have read and accepted our privacy policy. Your data will be used exclusively for this purpose.


Your Name*

Your Phone*

Company*

* Required fields

By submitting this form you confirm that you have read and accepted our privacy policy. Your data will be used exclusively for this purpose.