Target Identification, Phenotypic Screening Library.
Methodology and machine learning knowledge.
Examples of pathways – caloric restriction, oxidative stress regulation, sirtuins regulation, epigenetic modification, dopaminergic projections
• Examples of biological targets – TOR1, SCH9, GCN2, 8002, SIRT1, VEGF, ALOX5, PDE3, PDE7, HTR, CDK1, KCNK1, Serine proteases
• Examples of structural chemotypes – antioxidants, flavonoids, quinoids, tetracycline antibiotics, radical traps, adrenergic compounds
•Engel, N.; Mahlknecht, U. (2008) Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation. Int. J. Mol. Med. 21, 223–232.
•Wood, J.G.; Rogina, B. et al. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686–689.
•Petrascheck, M.; Ye, X.; Buck, L.B. (2007) An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature 450, 553–556.
•Lublin, A.; et al. (2011) FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. PLoS One 6:e27762.
•Iouk, T.; Titorenko, V.I. (2017) A laboratory test of evolutionary aging theories. Aging (Albany NY) 9(3), 600–601.
•Wu, Z. et al. (2014) Tanshinones extend chronological lifespan in budding yeast Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 98, 8617–8628.