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Focused and targeted libraries

Focused and targeted libraries

During the course of our synthetic and screening endeavors, we have identified a range of approaches to both diverse and highly specialized (focused) compound selections.
You can see the current list of over 100 predesigned focused and targeted libraries below.
A custom selection that suits your specific screening needs could be dispatched in any custom format to you within 1-2 weeks.

Our computational, structural biology, synthetic and medicinal chemistry team follow current trends in modern structure-based drug discovery to add novel diverse and targeted compounds. The latter selections are aimed at tackling multiple targets, protein domains, pathways, cellular processes, etc. Representative examples of these biased libraries include modulators of numerous protein-protein interactions, stem cell differentiation, apoptosis, proteasome cascade including diverse ligases, autophagy, epigenetics machinery, cell cycle including quiescent cancer cells, motor proteins, mitochondrial homeostasis and cell energetic, viral targets, bacterial genome, protein folding machinery including scaffolding proteins and chaperones and many others. We have also assembled screening sets for agrochemical.

Our general approach to these sets include analysis of the available chemical and biological information, identification of key pathway nodules/targets, computational and ‘wet biology’ assessment of target draggability and potential binding domains. The resulting information is analyzed by our synthetic team in order to design scaffolds that are likely to interact with the designated targets yielding focused compound libraries. This selection is updated on a quarterly basis reflective of novel insight into molecular, cell biology, availability of novel ligands or overall trends in disease areas.

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