Anti-infective Library
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Infectious agents
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Prion |
Viral |
Bacterial |
Fungal |
Protozoal
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Diseases
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Creutzfeldt Jakob disease, Kuru, Fatal familial insomnia |
Influenza, Parainfluenza, Measles, Viral hepatitis, HIV infection, Cytomegalovirus infection, Meningitis |
Plague, Cholera, Dysentery, Salmonellosis, Streptococcal, Staphylococcal, Meningitis |
Epidermophytosis Candidiasis, Cryptococcosis, Aspergillosis, Mucormycosis Chromomycosis |
Amoebiasis, Crytosporidiosis Isosporiasis Toxoplasmosis, Malaria, Babesiosis, Balantidiasis Blastocystosis |
Combined annotated pool
Analyses of:
· isosteric & bioisosteric transformations
· hot-spots & crucial binding points
· scaffold hopping
· 2D topological & 3D similarity
· 2D & 3D fingerprints
· scaffold & target priority/profiling
CADD
· scaffold hopping
· 2D Similarity
· 2D/3D Topological analogues
· 3D Pharmacophore modeling
Approach
· Focus on novel chemistry
· Scaffold prioritization
