Your cart is empty.

Fragments Library

Files to download
Preferred format
Desirable size of the custom library selection
Number of compounds
Amount
Volume
uL
Description

ChemDiv’s Fragments Library contains 13,000 compounds.

Another approach to improve productivity of drug discovery programs is “fragment-based” drug design (FBDD). At the root of this strategy is the observation that “lead” compounds are not always as “drug-like” as the final FDA-approved drug that they precede. Specifically, as initial hits are being optimized, they tend to lead to compounds of higher molecular weight and higher lipophilicity.

At ChemDiv, we can assist you in the rational selection and design of scaffolds and the synthesis of some small series of lead-like fragments around them. The single lead compound is a source for the generation of several fragment series. The compounds chosen for synthesis possess lead-like properties. The fragments selected contain only C, H, N, O, S, P, F, Cl, and Br atoms. Fragments with undesirable properties are eliminated by applying our special medicinal chemistry filters. The fragments selected possess good water solubility (Clog SW > -3.0) required for HCS. Overall, fragments satisfy key features such as diversity, reduced structural complexity, drug-/lead likeness and possess a great potential for “fragment evolution” and “fragment linking”.

X
X
Send a message
Request a call

Your Name*

Your E-mail*

Company*

Type in your message here…*
* Required fields

By submitting this form you confirm that you have read and accepted our privacy policy. Your data will be used exclusively for this purpose.


Your Name*

Your Phone*

Company*

* Required fields

By submitting this form you confirm that you have read and accepted our privacy policy. Your data will be used exclusively for this purpose.