Library of Small Molecule Inhibitors of beta-Catenin Signaling
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ChemDiv proposes the new library of beta-catenin inhibitors/modulators. This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of bcatenin with different proteins involved in significant physiological processes. Library has been assembled using in house structural biology insight, molecular stimulation-modeling, virtual screening of ChemDiv’s novel chemistries and medicinal chemistry filtering/ranking of the resulting hits. A representative example of a 'druggable' 'hot spots' included specific topological features of the b-catenin interaction (e.g. positively-charged groove binders).
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