Your cart is empty.
MCL1 Targeted Library

MCL1 Targeted Library

Files to download
Preferred format
Desirable size of the custom library selection
Number of compounds
Amount
Volume
uL
Description
ChemDiv’s MCL1 Targeted Library contains 12,000 compounds.

Myeloid cell leukemia-1 (MCL-1), a member of antiapoptotic BCL-2 family proteins. MCL-1 is widely expressed in human tissues and is primarily located in the mitochondria in cells, in which it inserts into the mitochondrial membrane via a hydrophobic tail. The antiapoptotic function of MCL-1 is essential to cell survival and homeostasis. Amplification and overexpression of MCL-1 have been reported in various human tumors, including hematological malignancies and solid tumors.

Given the critical roles of BCL-2 family proteins in maintaining cellular homeostasis, perturbation of the complexes between pro- and antiapoptotic BCL-2 proteins or their levels of expression could alter the cellular homeostatic balance and lead to overcoming apoptosis. Such imbalances can lead to the immortalization of cancers. To achieve the effects of controlling cell fate, small molecules have been developed to compensate for the imbalance between pro- and antiapoptotic BCL-2 proteins and restore the apoptotic pathway. Significant progress has been made in the development of small-molecule MCL-1 inhibitors in recent years, and three MCL-1 selective inhibitors have advanced to clinical trials. [1]

[1] W. Xiang, C. Y. Yang, and L. Bai, “MCL-1 inhibition in cancer treatment,” Onco. Targets. Ther., vol. 11, pp. 7301–7314, 2018, doi: 10.2147/OTT.S146228.
X
X
Send a message
Request a call

Your Name*

Your E-mail*

Company*

Type in your message here…*

* Required fields
 
By submitting this form you confirm that you have read and accepted our privacy policy. Your data will be used exclusively for this purpose.


Your Name*

Your Phone*

Company*

* Required fields
 
By submitting this form you confirm that you have read and accepted our privacy policy. Your data will be used exclusively for this purpose.