Purine Based Nucleoside Library
Purine and pyrimidine nucleosides have been widely studied for the development of a range of antiviral drugs to prevent viral replication in infected cells. They have been particularly exploited to develop drugs against HBV, HCV, herpes simplex virus, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to be incorporated into growing DNA strands. They can act as chain terminators and inhibit viral DNA polymerase.