Mechanism of action

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Mechanism of action ✘

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GPCR Targeted Library

40,000 compounds

Small-molecule compounds that can be used in GPCR drug discovery. Dysregulation of these receptors causes diabetes, CNS disorders.

Histone Deacetylases (HDAC) Targeted Library

9,500 compounds

Set of small-molecule HDAC inhibitors. HDAC regulate gene expression and its inhibitors act against cancers, neurodegenerative and inflammatory diseases.

RAR (Nuclear receptors) Ligands Library

6,000 compounds

Set of RAR receptor antagonists. The retinoic acid receptor is a type of nuclear receptor which can also act as a transcription factor.

Receptor protein tyrosine phosphatases

3,900 compounds

RPTP Targeted Library is small-molecule inhibitors. Disruption of protein tyrosine phosphorylation contributes to a variety of human diseases.

Protein-Protein Interaction Library

222,500 compounds

PPI Library is a set of small-molecule modulators that have been designed for disrupting PPI and reducing its drawbacks.

Bromodomain Modulators Library

5,816 compounds

Bromodomain Modulators Library is a set of drug-like compounds aimed at modulating PPI of bromodomain-containing proteins with other vital proteins.

16,000 compounds

Molecules from c-Met Library target receptor tyrosine kinase. It prevents binding hepatocyte growth factor with c-Met which can lead to cancer.

Protein Arginine Methyltransferases Library

31,000 compounds

PRMT Library is set of small-molecule compounds with reported affinity against cancer-assosiated PRMTs.

Purinergic Library

3,500 compounds

Purinergic Library is a set of purinergic receptor antagonists. Such antagonists is used for thrombosis and stroke treatment.

Adenosine Receptors Targeted Library

21,000 compounds

Adenosine Receptors Targeted Library is a set of small-molecule ligands. They can be used for treating neurodegeneration diseases.

Androgen Receptor Antagonists Library

4,300 compounds

Androgen Receptor Antagonists Library is a set of non-steroidal small molecules for prostate cancer treatment.

Epitranscriptome Focused Small Molecule Library

21,000 compounds

Epitranscriptome Focused Small Molecule Library modulates the activity of proteins involving in aberrant RNA modification.

Glucocorticoid receptors Library

5,000 compounds

Glucocorticoid Receptors Library is small-molecule selective modulators of GR which regulates gene transcription.

MEF2-HDAC (class II) Modulators Library

6,000 compounds

MEF2-HDAC (class II) Modulators Library is a set of drug-like compounds aimed at modulating PPI of MEF2 with HDAC involved in physiological processes.

7,271 compounds

Set of GABAA receptor antagonists. These drug-like compounds inhibit the action of GABA and produce stimulant and convulsant effects.

Peptidomimetic Library

38,400 compounds

Small molecules that mimic the action of peptides thus modulating PPI. Protein secondary structures are targets for mimicry.

SH2 PTB Focused Library

7,000 compounds

SH2 PTB domains Focused Library is a set of inhibitors. SH2 and PTB are small protein modules that mediate PPIs involved in signal transduction pathways.

PPI Helix Turn 3D-Mimetics Library

74,000 compounds

PPI Helix Turn 3D Mimetics Library was designed on sp3-enriched scaffolds that mimic key recognition elements of protein secondary structure.

MDM2-p53 interaction inhibitors Library

23,000 compounds

MDM2-p53 Interaction Inhibitors Library is a set of drug-like compounds aimed at modulating PPI of MDM2 with p53 involved in tumorigenesis.

Alpha-Helix Mimetics Library

28,000 compounds

Alpha-Helix Mimetics Library is a set of peptidomimetics. Alpha-helices are key recognition elements of protein secondary structure.

Nonpeptide Peptidomimetics PPI Library

19,400 compounds

Library contains nonpeptide small-molecules that inhibit PPI. They are structural mimetics to target proteins.

TLR-8 ligands Library

TLR-8 Ligands Library is a set of small-molecule TLR-8 agonists. They can be used in adjuvantation research and for the treatment of ovarian cancer.

Peptidomimetics of Beta-Turn Motifs Library

2,679 compounds

Small-molecule compounds that mimic the action of protein and modulates PPI.

Recognition Elements PPI Library

26,000 compounds

Recognition Elements PPI Library includes conformationally constrained analogues of bioactive peptides: gamma-, beta-turns, dipeptide mimetics.

Macrocycles Library

3,300 compounds

Macrocycles Library is a set of macrocyclic peptidomimetics that are potential PPI modulators. It is unique spiro and fused scaffolds.

Cyclic Ugi PPI Library

10,000 compounds

Set of PPI modulators. Cyclic lactam amides result from the Ugi reaction of bifunctional keto carboxylic acids.

Anti-Aging Library

50,000 compounds

Anti-Aging Library is small molecules targeting cellular pathways and biological targets that are implicated in aging.

Bcl2-PPI Inhibitors Library

11,000 compounds

Bcl2 PPI Inhibitors Library is small molecules that inhibit regulators of programmed cell death.

Epigenetics Focused Set

30,431 compounds

Focused Epigenetics Library is a set of small-molecule modulators that target epigenetic proteins.

Neuropeptide S Library

3,000 compounds

Neuropeptide S Library is a set of small-molecule NPSR ligands. They can be used in psychiatric disorders treatment as anxiolytics and analgesics.

12,000 compounds

SH2 Domain Library is a set of inhibitors. SH2 are modular units, which bind to tyrosyl-phosphorylated peptide on their target protein mediating PPI.

Chemokine Receptor-Targeted Library

20,000 compounds

Chemokine Receptor Targeted Library is a set of small-molecule ligands. Modulation of chemokine receptor is used in the treatment of inflammatory diseases.

PDZ PPI Library

4,000 compounds

Selective small-molecule PDZ inhibitors. They help to overcome drawbacks of PPI.

PPI Inhibitors Tripeptide Mimetics

25,000 compounds

PPI Tripeptide Mimetics Library is small-molecule PPI inhibitors that mimic significant endogenous tripeptides.

19,000 compounds

Spiro Library is a set of scaffolds with twisted structure of two or more rings for the design of new therapeutic agents.

Eccentric PPI Library

13,000 compounds

Eccentric PPI Library is a set of unusual ring systems (scaffolds) that lie outside the field of (hetero)aromatic systems.

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