Mechanism of action

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GPCR Targeted Library

29,185 compounds

Small-molecule compounds that can be used in GPCR drug discovery. Dysregulation of these receptors causes diabetes, CNS disorders.

NOTUM (Wnt signaling) Library

4,003 compounds

Small molecules that can inhibit NOTUM thus potentially treating diseases caused by dysregulation of Wnt signaling.

Carbonic Anhydrase II Library

5,000 compounds

Carbonic anhydrase II library is a set of compounds belonging to the sulfonamides, mercaptans and phenols aimed at modulating of Carbonic anhydrase II activity

RAR (Nuclear receptors) Ligands Library

6,767 compounds

Set of RAR receptor antagonists. The retinoic acid receptor is a type of nuclear receptor which can also act as a transcription factor.

15,080 compounds

Molecules from c-Met Library target receptor tyrosine kinase. It prevents binding hepatocyte growth factor with c-Met which can lead to cancer.

Histone Deacetylases (HDAC) Targeted Library

9,769 compounds

Set of small-molecule HDAC inhibitors. HDAC regulate gene expression and its inhibitors act against cancers, neurodegenerative and inflammatory diseases.

Protein Arginine Methyltransferases Library

27,102 compounds

PRMT Library is set of small-molecule compounds with reported affinity against cancer-assosiated PRMTs.

Receptor protein tyrosine phosphatases

3,765 compounds

RPTP Targeted Library is small-molecule inhibitors. Disruption of protein tyrosine phosphorylation contributes to a variety of human diseases.

Protein-Protein Interaction Library

211,413 compounds

PPI Library is a set of small-molecule modulators that have been designed for disrupting PPI and reducing its drawbacks.

Androgen Receptor Antagonists Library

4,244 compounds

Androgen Receptor Antagonists Library is a set of non-steroidal small molecules for prostate cancer treatment.

Glucocorticoid receptors Library

4,768 compounds

Glucocorticoid Receptors Library is small-molecule selective modulators of GR which regulates gene transcription.

Recognition Elements PPI Library

23,943 compounds

Recognition Elements PPI Library includes conformationally constrained analogues of bioactive peptides: gamma-, beta-turns, dipeptide mimetics.

Bromodomain Modulators Library

5,430 compounds

Bromodomain Modulators Library is a set of drug-like compounds aimed at modulating PPI of bromodomain-containing proteins with other vital proteins.

Peptidomimetic Library

36,711 compounds

Small molecules that mimic the action of peptides thus modulating PPI. Protein secondary structures are targets for mimicry.

Epitranscriptome Focused Small Molecule Library

20,989 compounds

Epitranscriptome Focused Small Molecule Library modulates the activity of proteins involving in aberrant RNA modification.

MEF2-HDAC (class II) Modulators Library

4,805 compounds

MEF2-HDAC (class II) Modulators Library is a set of drug-like compounds aimed at modulating PPI of MEF2 with HDAC involved in physiological processes.

7,123 compounds

Set of GABA receptor antagonists. These drug-like compounds inhibit the action of GABA and produce stimulant and convulsant effects.

Purinergic Library

3,271 compounds

Purinergic Library is a set of purinergic receptor antagonists. Such antagonists are used for thrombosis and stroke treatment.

Adenosine Receptors Targeted Library

19,626 compounds

Adenosine Receptors Targeted Library is a set of small-molecule ligands. They can be used for treating neurodegeneration diseases.

Peptidomimetics of Beta-Turn Motifs Library

2,123 compounds

Small-molecule compounds that mimic the action of protein and modulates PPI.

TLR-8 ligands Library

TLR-8 Ligands Library is a set of small-molecule TLR-8 agonists. They can be used in adjuvantation research and for the treatment of ovarian cancer.

Alpha-Helix Mimetics Library

24,737 compounds

Alpha-Helix Mimetics Library is a set of peptidomimetics. Alpha-helices are key recognition elements of protein secondary structure.

Nonpeptide Peptidomimetics PPI Library

18,417 compounds

Library contains nonpeptide small-molecules that inhibit PPI. They are structural mimetics to target proteins.

MDM2-p53 interaction inhibitors Library

21,144 compounds

MDM2-p53 Interaction Inhibitors Library is a set of drug-like compounds aimed at modulating PPI of MDM2 with p53 involved in tumorigenesis.

Macrocycles Library

2,335 compounds

Macrocycles Library is a set of macrocyclic peptidomimetics that are potential PPI modulators. It is unique spiro and fused scaffolds.

SH2 PTB Focused Library

5,886 compounds

SH2 PTB domains Focused Library is a set of inhibitors. SH2 and PTB are small protein modules that mediate PPIs involved in signal transduction pathways.

PPI Helix Turn 3D-Mimetics Library

68,388 compounds

PPI Helix Turn 3D Mimetics Library was designed on sp3-enriched scaffolds that mimic key recognition elements of protein secondary structure.

Cyclic Ugi PPI Library

9,487 compounds

Set of PPI modulators. Cyclic lactam amides result from the Ugi reaction of bifunctional keto carboxylic acids.

Anti-Aging Library

44,952 compounds

Anti-Aging Library is small molecules targeting cellular pathways and biological targets that are implicated in aging.

Neuropeptide S Library

2,800 compounds

Neuropeptide S Library is a set of small-molecule NPSR ligands. They can be used in psychiatric disorders treatment as anxiolytics and analgesics.

Epigenetics Focused Set

25,883 compounds

Focused Epigenetics Library is a set of small-molecule modulators that target epigenetic proteins.

Bcl2-PPI Inhibitors Library

11,568 compounds

Bcl2 PPI Inhibitors Library is small molecules that inhibit regulators of programmed cell death.

10,440 compounds

SH2 Domain Library is a set of inhibitors. SH2 are modular units, which bind to tyrosyl-phosphorylated peptide on their target protein mediating PPI.

PPI Inhibitors Tripeptide Mimetics

23,722 compounds

PPI Tripeptide Mimetics Library is small-molecule PPI inhibitors that mimic significant endogenous tripeptides.

Chemokine Receptor-Targeted Library

18,150 compounds

Chemokine Receptor Targeted Library is a set of small-molecule ligands. Modulation of chemokine receptor is used in the treatment of inflammatory diseases.

20,563 compounds

Spiro Library is a set of scaffolds with twisted structure of two or more rings for the design of new therapeutic agents.

Eccentric PPI Library

12,103 compounds

Eccentric PPI Library is a set of unusual ring systems (scaffolds) that lie outside the field of (hetero)aromatic systems.

PDZ PPI Library

3,055 compounds

Selective small-molecule PDZ inhibitors. They help to overcome drawbacks of PPI.

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