PPI modulators

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Protein-Protein Interaction Library

222,500 compounds

PPI Library is a set of small-molecule modulators that have been designed for disrupting PPI and reducing its drawbacks.

Bromodomain Modulators Library

5,816 compounds

Bromodomain Modulators Library is a set of drug-like compounds aimed at modulating PPI of bromodomain-containing proteins with other vital proteins.

MEF2-HDAC (class II) Modulators Library

6,000 compounds

MEF2-HDAC (class II) Modulators Library is a set of drug-like compounds aimed at modulating PPI of MEF2 with HDAC involved in physiological processes.

Peptidomimetic Library

38,400 compounds

Small molecules that mimic the action of peptides thus modulating PPI. Protein secondary structures are targets for mimicry.

SH2 PTB Focused Library

7,000 compounds

SH2 PTB domains Focused Library is a set of inhibitors. SH2 and PTB are small protein modules that mediate PPIs involved in signal transduction pathways.

PPI Helix Turn 3D-Mimetics Library

74,000 compounds

PPI Helix Turn 3D Mimetics Library was designed on sp3-enriched scaffolds that mimic key recognition elements of protein secondary structure.

MDM2-p53 interaction inhibitors Library

23,000 compounds

MDM2-p53 Interaction Inhibitors Library is a set of drug-like compounds aimed at modulating PPI of MDM2 with p53 involved in tumorigenesis.

Alpha-Helix Mimetics Library

28,000 compounds

Alpha-Helix Mimetics Library is a set of peptidomimetics. Alpha-helices are key recognition elements of protein secondary structure.

Nonpeptide Peptidomimetics PPI Library

19,400 compounds

Library contains nonpeptide small-molecules that inhibit PPI. They are structural mimetics to target proteins.

Peptidomimetics of Beta-Turn Motifs Library

2,679 compounds

Small-molecule compounds that mimic the action of protein and modulates PPI.

Macrocycles Library

3,300 compounds

Macrocycles Library is a set of macrocyclic peptidomimetics that are potential PPI modulators. It is unique spiro and fused scaffolds.

Recognition Elements PPI Library

26,000 compounds

Recognition Elements PPI Library includes conformationally constrained analogues of bioactive peptides: gamma-, beta-turns, dipeptide mimetics.

Cyclic Ugi PPI Library

10,000 compounds

Set of PPI modulators. Cyclic lactam amides result from the Ugi reaction of bifunctional keto carboxylic acids.

Bcl2-PPI Inhibitors Library

11,000 compounds

Bcl2 PPI Inhibitors Library is small molecules that inhibit regulators of programmed cell death.

12,000 compounds

SH2 Domain Library is a set of inhibitors. SH2 are modular units, which bind to tyrosyl-phosphorylated peptide on their target protein mediating PPI.

PDZ PPI Library

4,000 compounds

Selective small-molecule PDZ inhibitors. They help to overcome drawbacks of PPI.

PPI Inhibitors Tripeptide Mimetics

25,000 compounds

PPI Tripeptide Mimetics Library is small-molecule PPI inhibitors that mimic significant endogenous tripeptides.

19,000 compounds

Spiro Library is a set of scaffolds with twisted structure of two or more rings for the design of new therapeutic agents.

Eccentric PPI Library

13,000 compounds

Eccentric PPI Library is a set of unusual ring systems (scaffolds) that lie outside the field of (hetero)aromatic systems.

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