PPI modulators

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Protein-Protein Interaction Library

211,413 compounds

PPI Library is a set of small-molecule modulators that have been designed for disrupting PPI and reducing its drawbacks.

Bromodomain Modulators Library

5,430 compounds

Bromodomain Modulators Library is a set of drug-like compounds aimed at modulating PPI of bromodomain-containing proteins with other vital proteins.

MEF2-HDAC (class II) Modulators Library

4,805 compounds

MEF2-HDAC (class II) Modulators Library is a set of drug-like compounds aimed at modulating PPI of MEF2 with HDAC involved in physiological processes.

Peptidomimetic Library

36,711 compounds

Small molecules that mimic the action of peptides thus modulating PPI. Protein secondary structures are targets for mimicry.

Recognition Elements PPI Library

23,943 compounds

Recognition Elements PPI Library includes conformationally constrained analogues of bioactive peptides: gamma-, beta-turns, dipeptide mimetics.

Alpha-Helix Mimetics Library

24,737 compounds

Alpha-Helix Mimetics Library is a set of peptidomimetics. Alpha-helices are key recognition elements of protein secondary structure.

Nonpeptide Peptidomimetics PPI Library

18,417 compounds

Library contains nonpeptide small-molecules that inhibit PPI. They are structural mimetics to target proteins.

Peptidomimetics of Beta-Turn Motifs Library

2,123 compounds

Small-molecule compounds that mimic the action of protein and modulates PPI.

SH2 PTB Focused Library

5,886 compounds

SH2 PTB domains Focused Library is a set of inhibitors. SH2 and PTB are small protein modules that mediate PPIs involved in signal transduction pathways.

MDM2-p53 interaction inhibitors Library

21,144 compounds

MDM2-p53 Interaction Inhibitors Library is a set of drug-like compounds aimed at modulating PPI of MDM2 with p53 involved in tumorigenesis.

PPI Helix Turn 3D-Mimetics Library

68,388 compounds

PPI Helix Turn 3D Mimetics Library was designed on sp3-enriched scaffolds that mimic key recognition elements of protein secondary structure.

Macrocycles Library

2,335 compounds

Macrocycles Library is a set of macrocyclic peptidomimetics that are potential PPI modulators. It is unique spiro and fused scaffolds.

Cyclic Ugi PPI Library

9,487 compounds

Set of PPI modulators. Cyclic lactam amides result from the Ugi reaction of bifunctional keto carboxylic acids.

Bcl2-PPI Inhibitors Library

11,568 compounds

Bcl2 PPI Inhibitors Library is small molecules that inhibit regulators of programmed cell death.

10,440 compounds

SH2 Domain Library is a set of inhibitors. SH2 are modular units, which bind to tyrosyl-phosphorylated peptide on their target protein mediating PPI.

PPI Inhibitors Tripeptide Mimetics

23,722 compounds

PPI Tripeptide Mimetics Library is small-molecule PPI inhibitors that mimic significant endogenous tripeptides.

PDZ PPI Library

3,055 compounds

Selective small-molecule PDZ inhibitors. They help to overcome drawbacks of PPI.

20,563 compounds

Spiro Library is a set of scaffolds with twisted structure of two or more rings for the design of new therapeutic agents.

Eccentric PPI Library

12,103 compounds

Eccentric PPI Library is a set of unusual ring systems (scaffolds) that lie outside the field of (hetero)aromatic systems.

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