Opportunistic Pathogens of Immunocompromised Hosts Annotated Library
ChemDiv’s Opportunistic Pathogens of Immunocompromised Hosts Annotated Library contains 2,100 compounds. The library also includes activity data against 5 bacteria and 2 fungi. Each compound is annotated with toxicity data on human embryonic kidney cells as well as human red blood cells.
Opportunistic Infections (OIs) still remain a major cause of morbidity and death with either malignant or nonmalignant diseases. Opportunistic Infections (OIs) are defined as infections occurring due to bacteria, fungi, viruses, or parasites that normally do not cause a disease, but become pathogenic when the body’s defense system is impaired. OIs can also be represented by unusually severe infections caused by common pathogens.
The available data includes:
1) Names of pathogens: Straphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Acinetobacter baumanii, Pseudomonas aeruginosa, Candida albicans, Cryptococcus neoformans var. grubii.
2) Table with Percentile(50%) values of MIC, CC50 (cytotoxicity) and HC10 (haemolytic activity) for each organism
3)Table with individual MIC, CC50 (cytotoxicity) and HC10 (haemolytic activity) values for each organism, as well as Dmax values.
4) Individual data points for import in in-house databases. Haemolysis also reports the HC50 values, which is used to calculate the HC10 values.
This library is available for immediate shipping and could be conveniently formatted in any type of 96- or 384-well plates.